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Molecular biology of P-glycoprotein

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Molecular and Clinical Advances in Anticancer Drug Resistance

Part of the book series: Cancer Treatment and Research ((CTAR,volume 57))

Abstract

Since the advent of chemotherapy it has been observed that certain types of cancer are rarely sensitive to treatment with chemotherapy. Other cancers that are initially responsive to treatment eventually become resistant to the treatment regimen being used and to some other drugs as well. Resistance to chemotherapy remains one of the fundamental barriers to curative treatment. The mechanisms by which tumor cells become drug resistant have been under intensive study. It is clear from the accumulated data that drug resistance is a complex phenomenon, including more than one mechanism. Resistance may be caused by a change in one, more than one, facet of drug interaction with a cell, from drug influx/efflux and drug metabolism to drug-target site interactions.

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  1. Marilyn M. Cornwell
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  1. Fox Chase Cancer Center, USA

    Robert F. Ozols

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Cornwell, M.M. (1991). Molecular biology of P-glycoprotein. In: Ozols, R.F. (eds) Molecular and Clinical Advances in Anticancer Drug Resistance. Cancer Treatment and Research, vol 57. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3872-1_3

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  • DOI: https://doi.org/10.1007/978-1-4615-3872-1_3

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