Abstract
Glutathione (GSH) and synthetic aminothiols, such as N-acetylcysteine (NAC), play an important role as inhibitors of mutagenesis and carcinogenesis (1). The present paper will update the studies carried out in our laboratories, which will be discussed according to a mechanistic approach. In Table 1, reporting the classification of inhibitors of mutagenesis and carcinogenesis proposed by De Flora and Ramel (2), the arrows indicate the mechanisms that we have investigated so far in the case of aminothiols.
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De Flora, S., Camoirano, A., Izzotti, A., Zanacchi, P., Bagnasco, M., Cesarone, C.F. (1991). Antimutagenic and Anticarcinogenic Mechanisms of Aminothiols. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_40
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DOI: https://doi.org/10.1007/978-1-4615-3850-9_40
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