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Role of type IV collagenases in human breast cancer

  • Chapter
Genes, Oncogenes, and Hormones

Part of the book series: Cancer Treatment and Research ((CTAR,volume 61))

Abstract

In breast cancer, as in most other malignant human tumors, the most ominous aspect of the oncogenic process is the local invasion and subsequent metastasis of the primary tumor. The single most important prognostic factor in patients with breast cancer is the presence of neoplastic cells in the axillary lymph nodes [1]. If these nodes are positive for cancer cells, there is the potential for the dissemination of tumor cells to the lungs, adrenals, liver, bone, and brain. The growth of metastatic foci at these distant sites is the most common cause of death for patients with breast cancer. Although our understanding of the pathogenesis of metastasis formation has increased, progress has been slowed by the profound complexity of the metastatic cascade. One successful strategy for dealing with this complexity has been to separate the metastatic process into a series of steps and to define specific genes or gene products that are activated at each step [2]. This has led to the emergence of several basic themes, which have allowed identification of new strategies for the diagnosis and therapy of breast cancer.

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Authors
  1. William G. Stetler-Stevenson
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  2. Lance A. Liotta
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  3. Peter D. Brown
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  1. Lombardi Cancer Research Center, Georgetown University School of Medicine, Washington, D.C., USA

    Robert B. Dickson  & Marc E. Lippman  & 

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Stetler-Stevenson, W.G., Liotta, L.A., Brown, P.D. (1991). Role of type IV collagenases in human breast cancer. In: Dickson, R.B., Lippman, M.E. (eds) Genes, Oncogenes, and Hormones. Cancer Treatment and Research, vol 61. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3500-3_2

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  • DOI: https://doi.org/10.1007/978-1-4615-3500-3_2

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