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Delta Virus as a Vector for the Delivery of Biologically-Active RNAs: Possibly a Ribozyme Specific for Chronic Hepatitis B Virus Infection

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Innovations in Antiviral Development and the Detection of Virus Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 312))

Abstract

RNA species have been designed that demonstrate specific biological activities. Examples include the antisense RNA oligonucleotides (Weintraub et al., 1985) and catalytic RNAs that act as endoribonucleases (Haseloff and Gerlach, 1988). And, recently (Ellington and Szostak 1990) have developed an even more general method of allowing the selection, in the test tube, of RNA species that can bind to a chosen domain, for example on an RNA, DNA, or protein.

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References

  • Chen, P.J., Kalpana, G., Goldberg, J., Mason, W., Werner, B., Gerin, J., and Taylor, J., 1986, Structure and replication of the genome of hepatitis delta virus, Proc. Natl. Acad. Sci. USA, 83:8774.

    Article  PubMed  CAS  Google Scholar 

  • Ellington and Szostak, 1990, In vitro selection of RNA molecules that bind specific ligands, Nature, 346:818.

    Google Scholar 

  • Haseloff, J., and Gerlach, W.L., 1988, Simple RNA enzymes with new and highly specific endoribonuclease activities, Nature, 334:585.

    Article  PubMed  CAS  Google Scholar 

  • Kuo, M.Y.-P., Chao, M., and Taylor, J., 1989, Initiation of replication of the human hepatitis delta virus genome from cloned DNA: Role of the delta antigen, J. Virol., 63:1945.

    PubMed  CAS  Google Scholar 

  • Kuo, M.Y.-P., Goldberg, J., Coates, L., Mason, W., Gerin, J., and Taylor, J., 1988, Molecular cloning of hepatitis delta virus RNA from an infected woodchuck liver: sequence, structure, and application, J. Virol., 62:1855.

    PubMed  CAS  Google Scholar 

  • Taylor, J., 1990a, The structure and replication of human hepatitis delta virus, Seminars in Virol., 1:135.

    Google Scholar 

  • Taylor, J., 1990b, Hepatitis delta virus: cis and trans function needed for replication, Cell, 61:371.

    Article  CAS  Google Scholar 

  • Weintraub, H., Izant, J.G., and Harland, R., 1985, Antisense RNA as a molecular tool for genetic analysis, Trends in Gen., 1:22.

    Article  CAS  Google Scholar 

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© 1992 Springer Science+Business Media New York

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Hsieh, SY., Taylor, J. (1992). Delta Virus as a Vector for the Delivery of Biologically-Active RNAs: Possibly a Ribozyme Specific for Chronic Hepatitis B Virus Infection. In: Block, T.M., Jungkind, D., Crowell, R.L., Denison, M., Walsh, L.R. (eds) Innovations in Antiviral Development and the Detection of Virus Infections. Advances in Experimental Medicine and Biology, vol 312. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3462-4_12

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  • DOI: https://doi.org/10.1007/978-1-4615-3462-4_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6533-4

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