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Taurine and Niacin Offer a Novel Therapeutic Modality in Prevention of Chemically-Induced Pulmonary Fibrosis in Hamsters

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Taurine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 315))

Abstract

Taurine, a sulfur containing ß-amino acid, is present in high concentrations in most mammalian tissues. Although taurine is not a constituent of mammalian proteins, it plays an important role in the pathophysiology of cardiovascular and nervous systems1,2 and conjugation of bile acids3. The beneficial effects of taurine against oxidant-induced tissue injury have been attributed to its ability to stabilize biomembranes4,5 and scavenge reactive oxygen species (ROS) including hypochlorous acid6–8. Several effects of taurine on the cardiovascular and central nervous systems may be related to calcium redistribution since taurine alters calcium transport9,10. It has been demonstrated that exogenously administered taurine would offer protection against oxidant-induced lung damage11,12 In addition, Nakashima et a1.13 reported therapeutic and prophylactic effects of taurine on experimentally-induced liver injury.

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Authors and Affiliations

  1. Department of Veterinary Pharmacology and Toxicology, University of California Davis, CA, 95616, USA

    S. N. Giri & Q. Wang

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  1. S. N. Giri
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  2. Q. Wang
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Editors and Affiliations

  1. Texas Tech University Health Sciences Center, Lubbock, Texas, USA

    John B. Lombardini

  2. University of South Alabama School of Medicine, Mobile, Alabama, USA

    Stephen W. Schaffer

  3. Osaka University Medical School, Osaka, Japan

    Junichi Azuma

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Giri, S.N., Wang, Q. (1992). Taurine and Niacin Offer a Novel Therapeutic Modality in Prevention of Chemically-Induced Pulmonary Fibrosis in Hamsters. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine. Advances in Experimental Medicine and Biology, vol 315. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3436-5_39

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  • DOI: https://doi.org/10.1007/978-1-4615-3436-5_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6520-4

  • Online ISBN: 978-1-4615-3436-5

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