Abstract
Photon migration in highly scattering tissues such as muscle and brain gives optical pathlengths that are dependent upon absorption and scattering parameters, μa μs’. Determination of these parameters gives the correct concentration of principal absorber such as hemoglobin in the red region of the spectrum. Determinations of scatter factor in functioning and pathological tissues are made.
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B. Chance, S. Nioka, J. Kent, K. McCully et al, Time Resolved Spectroscopy of Hemoglobin and Myoglobin Resting and Ischemic Muscle. Anal. Biochem. 174: 698–707 (1988).
B. Chance, J.S. Leigh, H. Miyake, D.S. Smith, et al Comparison of Time Resolved and Unresolved Measurements of Deoxyhemoglobin in Brain. Proc. Natl. Acad. Sci. USA 85: 4971–4975 (1988).
E.M. Sevick, and B. Chance, Quantitation of Time- and Frequency-Resolved Optical Spectra for the Determination of Tissue Oxygenation. Anal. Biochem. 195: 330–351 (1991).
J.G. Fujimoto, S. De Silversti, E.P. Ippen, R. Margolis, and A. Oseroff, Femtosecond Optical Ranging in Biological Sytstems. Opt. Lett., 11: 150–152 (1986).
Hazeki, O. and Tamura, M. (1988) The Quantitative Analysis of Hemoglobin Oxygenation State of Rat Brain in situ as Monitored by Near-Infrared Spectrophometry. J. Appl. Physiol. 64: 796–802.
B. Chance, J. Haselgrove, J.S. Leigh, M. Patterson, and E. Sevick, Optical Ranging of Muscle and Brain. IEEE Transactions on Microwave Theory and Techniques (Symposium Issue of Spectrum - December 1991) In press (1991).
D.T. Delpy, M. Cope, P. van der Zee, S.R. Arridge, S Wray, and J.S. Wyatt, Estimation of Optical Pathlength through Tissue from Direct Time of Flight Measurement. Phys. Med. & Biol. 33: 1433–1442 (1988).
D.T. Delpy, this volume (1991).
M.S. Patterson, B. Chance, and B.C. Wilson, Time Resolved Reflectance and Trans-mittance for the Noninvasive Measurement of Tissue Optical Properties. J. Appl. Optics 28: 2331–2336 (1989).
M.S. Patterson, J.D. Moulton, B.C. Wilson, and B. Chance, Applications of Time-Resolved Light Scattering Measurements to Photodynamic Therapy Dosimetry. In: Photodynamic Therapy: Mechanisms II Proc. Soc. Photo Optical Instrum. Engr. 1203:62–75 (1990).
J. Fishkin, E. Gratton, M.J. vandeVen, and W.W. Mantulin, Diffusion of Intensity-Modulated Near-Infrared Light in Turbid Media. In: Proceedings of Time-Resolved Spectroscopy and Imaging of Tissues, SPIE (B. Chance, ed) SPIE, Bellingham, WA, 1431:122–135(1991).
S.L. Jacques, and S.T. Flock, Effect of Boundary on Time-Resolved Reflectance: Measurements with a Prototype Endoscopie Catheter. In: Proceedings of Time-Resolved Spectroscopy and Imaging of Tissues, SPIE (B. Chance, ed) SPIE, Bellingham, WA, 1431:12–28 (1991).
S.L. Jacques, and S.T. Flock, Effect of Boundary on Time-Resolved Reflectance: Measurements with a Prototype Endoscopie Catheter. In: Proceedings of Time-Resolved Spectroscopy and Imaging of Tissues, SPIE (B. Chance, ed) SPIE, Bellingham, WA, 1431:12–28 (1991).
W.L. Butler, Absorption of Light by Turbid Materials. J. Opt. Soc. Amer.52:292–299 (1962); see also P. Williams, and K. Norris, Near-Infrared Technology in the Agricultural and Food Industries. Am. Assoc. of Cereal Chemists, Inc, St. Paul, NM (1987).
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Chance, B., Wang, N.G., Maris, M., Nioka, S., Sevick, E. (1992). Quantitation of Tissue Optical Characteristics and Hemoglobin Desaturation by Time- and Frequency Resolved Multi-Wavelength Spectrophotometry. In: Erdmann, W., Bruley, D.F. (eds) Oxygen Transport to Tissue XIV. Advances in Experimental Medicine and Biology, vol 317. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3428-0_31
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DOI: https://doi.org/10.1007/978-1-4615-3428-0_31
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