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In Vitro Evaluation of 10B-BPA for Melanoma at Moata - Joint Work between Japan and Australia BNCT Research Teams

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Progress in Neutron Capture Therapy for Cancer

Abstract

A variety of conjugated compounk have been synthesized in Japan, the USA and Australia. Among these 10B-compounds, 10B1-paraboronophenylalanine (10B1-BPA) has been widely tested in vitro and in vivo for boron neutron capture therapy of melanoma. We have shown that 10B1-BPA is selectively incorporated into melanom cells in vitro1) and in vivo 2). Neutron capture therapy (NCT) using 10B1-BPA has been demonstrated not only to be highly lethal for melanoma cells in vitro3) but also to be effective for suppressing melanoma growth in vivo.

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Rferences

  1. M. Ichihashi, M. Ueda, K. Hayashibe, S. Hatta, M. Tsuji, Y. Mishima, H. Fukuda, T. Kobayashi, K. Kandw, In vitro radiobiological evaluation of selective killing effects of 10B1-paraboronophenylalanine HCI in the thermal neutron capture therapy of malignant melanoma cells. KURRI-TR-260:23–31, 1985.

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Author information

Authors and Affiliations

  1. Department of Dermatology, Special Institute for Cancer Neutron Capture Therapy, Kobe University School of Medicine, Kobe, 650, Japan

    M. Ichihashi & Y. Mishima

  2. National Institute of Radiological Science, Chiba, 280, Japan

    H. Fukuda

  3. Biomedicine and Health Program, ANSTO, NSW, 2234, Australia

    J. K. Brown, M. H. Mountford, B. J. Allen & J. G. Wilson

Authors
  1. M. Ichihashi
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  2. H. Fukuda
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  3. J. K. Brown
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  4. M. H. Mountford
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  5. B. J. Allen
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  6. J. G. Wilson
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  7. Y. Mishima
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Editor information

Editors and Affiliations

  1. Australian Nuclear Science and Technology Organisation, Menai, New South Wales, Australia

    Barry J. Allen  & Baiba V. Harrington  & 

  2. University of Sydney, Sydney, New South Wales, Australia

    Douglas E. Moore

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© 1992 Springer Science+Business Media New York

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Ichihashi, M. et al. (1992). In Vitro Evaluation of 10B-BPA for Melanoma at Moata - Joint Work between Japan and Australia BNCT Research Teams. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_85

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  • DOI: https://doi.org/10.1007/978-1-4615-3384-9_85

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6494-8

  • Online ISBN: 978-1-4615-3384-9

  • eBook Packages: Springer Book Archive

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