Abstract
Intracavity and interstitial 252Cf implants have been used to treat a number of tumor types including gynecological tumors and glioblastoma1,2,3, the former with encouraging results. As a neutron source, 252Cf offers certain theoretical advantages over photon therapy (i.e., in treating tumors with significant hypoxic or necrotic components). With the recent availability of 10B-labelled tumor seeking compounds, the usefulness of 252Cf may be further improved by augmenting the 252Cf dose to tumor with an additional dose due to the fission (following thermal neutron capture) of 10B located in the tumor itself. While the high mean neutron energy permits 252Cf to deliver a high LET, low OER dose to tumor on a macroscopic scale, thermalization of neutrons followed by 10B capture may augment this dose at the cellular level if adequate loading of tumor cells with 10B is possible. This paper presents results of a Monte Carlo simulation study which investigates the dosimetric characteristics of linear 252Cf sources and the quantitative increase in tumor dose possible with the addition of 10B. Comparison of the presented Monte Carlo results with experimental and analytic dosimetry data presented in the literature will also be made.
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© 1992 Springer Science+Business Media New York
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Yanch, J.C., Zamenhof, R.G., Wierzbicki, J., Maruyama, Y. (1992). Comparison of Dose Distributions with 10Boron Augmented Sources of 252Cf Obtained by Monte Carlo Simulation and by Experimental Measurement. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_39
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DOI: https://doi.org/10.1007/978-1-4615-3384-9_39
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