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Biodistribution of Boron Sulfhydryl (BSH) in Humans: A Quality Control of Analytical Methods*

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Progress in Neutron Capture Therapy for Cancer

Abstract

Current methods for quantitative determination of boron in biological tissues include Inducticely Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) and Quantitative Neutron Capture Radiography (QNCR). These sophisticated techniques measure independent physical properties. Precise values of B-10 concentrations are reported in literature, even in the subppm range. Nevertheless, convincing data on calibration curves and quality control are lacking. Furthermore, there are no reports on direct comparison of ICP-AES and QNCR. In order to obtain reliable data, we analyzed our specimens - whenever available - by both methods.

This work has been supported by the Fonds National de la Recherche Scientifique, the Ligue Suisse contre le Cancer, the Ligue Vaudoise contre le Cancer, and the Commission of the European Communities.

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References

  1. Bauer WF, Johnson DA, Steele et al.: Gross boron determination in biological samples by inductively coupled plasma atomic emission spectroscopy. Strahlenther Onkol 165:176–179, 1989

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  2. Gabel D, Holstein H and Larson B: Quantitative neutron capture radiography for studying the biodistribution of tumor-seeking boron-containing compounds. Cancer Res 47:5451–5454, 1987

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Authors and Affiliations

  1. Department of Neurosurgery, CHUV, 1011, Lausanne, Switzerland

    G. Stragliotto & H. Fankhauser

  2. Institute of Analytical Chemistry, University of Lausanne, 1005, Lausanne, Switzerland

    P. Zbinden

  3. Department of Radiation Sciences, University of Uppsala, 751-21, Uppsala, Sweden

    O. Pettersson

Authors
  1. G. Stragliotto
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  2. P. Zbinden
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  3. O. Pettersson
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  4. H. Fankhauser
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Editor information

Editors and Affiliations

  1. Australian Nuclear Science and Technology Organisation, Menai, New South Wales, Australia

    Barry J. Allen  & Baiba V. Harrington  & 

  2. University of Sydney, Sydney, New South Wales, Australia

    Douglas E. Moore

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© 1992 Springer Science+Business Media New York

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Stragliotto, G., Zbinden, P., Pettersson, O., Fankhauser, H. (1992). Biodistribution of Boron Sulfhydryl (BSH) in Humans: A Quality Control of Analytical Methods* . In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_120

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  • DOI: https://doi.org/10.1007/978-1-4615-3384-9_120

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6494-8

  • Online ISBN: 978-1-4615-3384-9

  • eBook Packages: Springer Book Archive

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