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Tumour Localization of Boronated Porphyrins in an Intracerebral Model of Glioma

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Progress in Neutron Capture Therapy for Cancer

Abstract

Treatment of the most common cerebral tumour, cerebral glioma, is unsatisfactory as the tumour recurs due to inadequate local control (1). Photodynamic therapy (PDT) and Boron Neutron Capture Therapy (BNCT) offer some promise as adjuvant treatments for cerebral glioma. Several clinical trials have been reported utilizing PDT (for review see reference 1) and BNCT (2) to treat the high grade glioma, glioblastoma multiforme. We have investigated the pharmacokinetic tissue distribution of the photosensitizer Haematoporphyrin derivative (HpD), the nido carboranyl porphyrin, boron tetraphenyl porphine (BTPP) and the closo carboranyl monomeric protoporphyrin (BOPP) in CBA mice bearing the intracerebral C6 glioma xenograft (3).

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References

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Author information

Authors and Affiliations

  1. Higginbotham Neuroscience Research Institute, Department of Surgery (Royal Melbourne Hospital), University of Melbourne, Parkville, 3052, Australia

    J. S. Hill, A. H. Kaye, M. F. Gonzales, S. S. Stylli & Y. Nakamura

  2. Department of Pharmaceutical Chemistry, University of California, San Francisco, 94143-0446, California, USA

    S. B. Kahl

  3. Department of Applied Science, Phillip Institute of Technology, Bundoora, 3083, Australia

    N. J. Vardaxis

  4. Biorad Pty Ltd., Hawthorn, 3122, Australia

    C. I. Johnson

Authors
  1. J. S. Hill
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  2. S. B. Kahl
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  3. A. H. Kaye
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  4. M. F. Gonzales
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  5. N. J. Vardaxis
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  6. C. I. Johnson
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  7. S. S. Stylli
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  8. Y. Nakamura
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Editor information

Editors and Affiliations

  1. Australian Nuclear Science and Technology Organisation, Menai, New South Wales, Australia

    Barry J. Allen  & Baiba V. Harrington  & 

  2. University of Sydney, Sydney, New South Wales, Australia

    Douglas E. Moore

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© 1992 Springer Science+Business Media New York

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Hill, J.S. et al. (1992). Tumour Localization of Boronated Porphyrins in an Intracerebral Model of Glioma. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_111

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  • DOI: https://doi.org/10.1007/978-1-4615-3384-9_111

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6494-8

  • Online ISBN: 978-1-4615-3384-9

  • eBook Packages: Springer Book Archive

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