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Liposomes as Carriers of Boronated Thiouracils for NCT of Melanoma

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Progress in Neutron Capture Therapy for Cancer

Abstract

5- (3- (1,2 -decaboronyl)propyl) -6-methyl-thiouracil, DBTU-1, and 5- (1,2-decaboronyl-methyl) -6-methyl-thiouracil, DBTU-2, are boron derivatives of thiouracil, which is reported to localise in melanoma as a false precursor in the synthesis of melanin.1,2 The chemical structures of DBTU-1 and DBTU-2 are given in Figure 1. Their preparation and characterisation is to be found elsewhere.3

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References

  1. RG Fairchild, S Packer, D Greenberg, P Som, AB Brill, I Fand and WP McNally, Thiouracil distribution in mice carrying transplantable melanoma. Cancer Res., 42, 5126–5132, 1982.

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© 1992 Springer Science+Business Media New York

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Moore, D.E., Chandler, A.K., Corderoy-Buck, S., Wilson, J.G., Allen, B.J. (1992). Liposomes as Carriers of Boronated Thiouracils for NCT of Melanoma. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_100

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  • DOI: https://doi.org/10.1007/978-1-4615-3384-9_100

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6494-8

  • Online ISBN: 978-1-4615-3384-9

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