Abstract
Exposure of experimental animals to chronic hypoxia induces pulmonary hypertension and right ventricular enlargement in a relatively short time period (for review see 1, 2). Cardiac enlargement may be due to an increased number of individual cell elements (hyperplasia) and their increased volume (hypertrophy) caused by increased protein synthesis. Participation of both processes in cardiac growth depends on cell type and age of the animal. Whereas connective tissue cells can proliferate during the whole ontogeny, the mitotic activity of ventricular myocytes is limited to a relatively short postnatal period; in rats it ceases 4–6 weeks after birth (3, 4).
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Pelouch, V., Ostádal, B., Kolár, F., Milerová, M., Grünermel, J. (1993). Chronic Hypoxia-Induced Right Ventricular Enlargement: Age-Dependent Changes of Collagenous and Non-Collagenous Cardiac Protein Fractions. In: Ostadal, B., Dhalla, N.S. (eds) Heart Function in Health and Disease. Developments in Cardiovascular Medicine, vol 140. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3090-9_15
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DOI: https://doi.org/10.1007/978-1-4615-3090-9_15
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