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Structure, Expression, and Regulation of the IGF-I Gene

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Current Directions in Insulin-Like Growth Factor Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 343))

Abstract

The insulin-like growth factors, IGF-I and IGF-II, are important regulators of growth, differentiation and maintenance of differentiated function (Daughaday and Rotwein, 1989), primarily through activation of the IGF-I receptor, a transmembrane tyrosine kinase (Ullrich et al., 1986). In addition to these typical growth factor-like effects, the IGFs, by virtue of their homology to insulin, and the similarity of the insulin and IGF-I receptors, can also elicit insulin-like metabolic effects. The latter effects are presumably the result of “heterologous” activation of the insulin receptor by the IGFs. As described elsewhere in this volume, the bioavailability and action of the IGFs are modulated by a family of IGF-binding proteins.

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Authors and Affiliations

  1. Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX, 78284, USA

    Martin L. Adamo

  2. Diabetes Branch, NIDDK, National Institutes of Health, Building 10, Room 8S-239, Bethesda, MD, 20892, USA

    Stefan Neuenschwander, Derek LeRoith & Charles T. Roberts Jr.

Authors
  1. Martin L. Adamo
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  2. Stefan Neuenschwander
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  3. Derek LeRoith
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  4. Charles T. Roberts Jr.
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Editor information

Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek Le Roith M.D., Ph.D.

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada Ph.D.

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Adamo, M.L., Neuenschwander, S., LeRoith, D., Roberts, C.T. (1994). Structure, Expression, and Regulation of the IGF-I Gene. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_1

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  • DOI: https://doi.org/10.1007/978-1-4615-2988-0_1

  • Publisher Name: Springer, Boston, MA

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