Skip to main content
SpringerLink
Log in

Neutrophil-Activating Peptide ENA-78

  • Chapter
The Chemokines

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 351))

Abstract

Neutrophil-activating peptide ENA-78 was recently isolated from a human type II-like epithelial cell line A549 (1). ENA-78 is a peptide of 78 amino acids and belongs to the C-X-C supergene family of the chemotactic cytokines (now called chemokines). The C-X-C family contains five other peptides with neutrophil-activating properties, interleukin-8 (IL-8) (2), three closely related members of the GRO family, GROα, GROβ and GROγ (3,4) and neutrophil-activating peptide 2 (NAP-2) (5). Two other members of the same subfamily, platelet factor 4 and interferon-γ induced peptide 10 (γ-IP10) have been shown not to be active on human neutrophils (6,7).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Walz, A., R. Burgener, B. Car, M. Baggiolini, S.L. Kunkel, and R.M. Strieter. 1991. Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8.J. Exp. Med.174: 1355–1362.

    Article  PubMed  CAS  Google Scholar 

  2. Baggiolini, M., A. Walz, and S.L. Kunkel. 1989. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.J. Clin. Invest.84: 1045–1049.

    Article  PubMed  CAS  Google Scholar 

  3. Haskill, S., A. Peace, J. Morris, S.A. Sporn, A. Anisowicz, S.W. Lee, T. Smith, G. Martin, P. Ralph, and R. Sager. 1990. Identification of three related human GRO genes encoding cytokine functions.Proc. Natl. Acad. Sci. USA87: 7732–7736.

    Article  PubMed  CAS  Google Scholar 

  4. Moser, B., I. Clark-Lewis, R. Zwahlen, and M. Baggiolini. 1990. Neutrophil-activating properties of the melanoma growth-stimulatory activity.J. Exp. Med.171: 1797–1802.

    Article  PubMed  CAS  Google Scholar 

  5. Walz, A. and M. Baggiolini. 1989. A novel cleavage product of b-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils.Biochem. Biophys. Res. Commun.159: 969–975.

    Article  PubMed  CAS  Google Scholar 

  6. Walz, A., B. Dewald, V. von Tscharner, and M. Baggiolini. 1989. Effects of the neutrophilactivating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils.J. Exp. Med.170: 1745–1750.

    Article  PubMed  CAS  Google Scholar 

  7. Dewald, B., B. Moser, L. Barella, C. Schumacher, M. Baggiolini, and I. Clark-Lewis. 1992. IP-10, a gamma-interferon-inducible protein related to interleukin-8, lacks neutrophil activating properties.Immunol. Lett.32: 81–84.

    Article  PubMed  CAS  Google Scholar 

  8. Baggiolini, M., B. Dewald, and A. Walz. 1992. Interleukin-8 and related chemotactic cytokines.In:“Inflammation: Basic principles and clinical correlates”, Gallin, J.I., Goldstein, LM., and Snyderman, R. eds., Raven Press, New York, pp. 247–263.

    Google Scholar 

  9. Walz, A. and M. Baggiolini. 1990. Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.J. Exp. Med.171: 449–454.

    Article  PubMed  CAS  Google Scholar 

  10. Schröder, J.-M., M. Sticherling, H.H. Henneicke, W.C. Preissner, and E. Christophers. 1990. IL-la or tumor necrosis factor-a stimulate release of three NAP-1/IL-8-related neutrophil chemotactic proteins in human dermal fibroblasts.J. Immunol.144: 2223–2232.

    PubMed  Google Scholar 

  11. Hébert, C.A., F.W. Luscinskas, J.-M. Kiely, and et al. 1990. IL-la or tumor necrosis factor-a stimulated release of three NAP-1/IL-8-related neutrophil chemotactic proteins in human dermal fibroblasts.J. Immunol.144: 2223–2232.

    Google Scholar 

  12. Walz, A., F. Meloni, I. Clark-Lewis, V. von Tscharner, and M. Baggiolini. 1991. [Ca2+]i, changes and respiratory burst in human neutrophils and monocytes induced by NAP-1/interleukin-8, NAP-2, and gro/MGSA. J. Leukocyte Biol. 50: 279–286.

    PubMed  CAS  Google Scholar 

  13. Besemer, J., A. Hujber, and B. Kuhn. 1989. Specific binding, internalization, and degradation of human neutrophil activating factor by human polymorphonuclear leukocytes.J. Biol. Chem.264: 17409–17415.

    PubMed  CAS  Google Scholar 

  14. Samanta, A.K., J.J. Oppenheim, and K. Matsushima. 1989. Identification and characterization of specific receptors for monocyte-derived neutrophil chemotactic factor (MDNCF) on human neutrophils.J. Exp. Med.169: 1185–1189.

    Article  PubMed  CAS  Google Scholar 

  15. Grob, P.M., E. David, T.C. Warren, R.P. DeLeon, P.R. Farina, and C.A. Homon. 1990. Characterization of a receptor for human monocyte-derived neutrophil chemotactic factor/inter-leukin8.J. Biol. Chem.265: 8311–8316.

    PubMed  CAS  Google Scholar 

  16. Murphy, P.M. and H.L. Tiffany. 1991. Cloning of complementary DNA encoding a functional human interleukin-8 receptor.Science253: 1280–1283.

    Article  PubMed  CAS  Google Scholar 

  17. Holmes, W.E., J. Lee, W.-J. Kuang, G.C. Rice, and W.I. Wood. 1991. Structure and functional expression of a human interleukin-8 receptor.Science253: 1278–1280.

    Article  PubMed  CAS  Google Scholar 

  18. Moser, B., C. Schumacher, V. von Tscharner, I. Clark-Lewis, and M. Baggiolini. 1991. Neutrophilactivating peptide 2 and gro/melanoma growth-stimulatory activity interact with neutrophil-activating peptide 1/interleukin 8 receptors on human neutrophils.J. Biol. Chem.266: 10666–10671.

    PubMed  CAS  Google Scholar 

  19. Clark-Lewis, I., C.M. Schumacher, M. Baggiolini, and B. Moser. 1991. Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities.J. Biol. Chem.266: 23128–23134.

    PubMed  CAS  Google Scholar 

  20. Hébert, C.A., R.V. Vitangcol, and J.B. Baker. 1991. Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding.J. Biol. Chem.266: 18989–18994.

    PubMed  Google Scholar 

  21. Leonard, E.J., T. Yoshimura, A. Rot, K. Noer, A. Walz, M. Baggiolini, D.A. Walz, EJ. Goetz’, and C.W. Castor. 1991. Chemotactic activity and receptor binding of neutrophil attractant/activation protein-1 (NAP-1) and structurally related host defense cytokines: Interaction of NAP-2 with the NAP-1 receptor.J. Leukocyte Biol.49: 258–265.

    PubMed  CAS  Google Scholar 

  22. Lindley, I., H. Aschauer, J.M. Seifert, C. Lam, W. Brunowsky, E. Kownatzki, M. Thelen, P. Peveri, B. Dewald, V. von Tscharner, A. Walz, and M. Baggiolini. 1988. Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: Biological equivalence between natural and recombinant neutrophil-activating factor.Proc. Natl. Acad. Sci. U.S.A.85: 9199–9203.

    Article  PubMed  CAS  Google Scholar 

  23. Gimbrone, M.A. Jr., M.S. Obin, A.F. Brock, E.A. Luis, P.E. Hass, C.A. Hébert, Y.K. Yip, D.W. Leung, D.G. Lowe, W.J. Kohr, W.C. Darbonne, K.B. Bechtol, and J.B. Baker. 1989. Endothelial interleukin-8: A novel inhibitor of leukocyte-endothelial interactions.Science246: 1601–1603.

    Article  PubMed  CAS  Google Scholar 

  24. Strieter, R.M., S.L. Kunkel, M.D. Burdick, P.M. Lincoln, and A. Walz. 1992. The detection of a novel neutrophil-activating peptide (ENA-78) using a sensitive ELISA.Immunol. Invest.21: 589–596.

    Article  PubMed  CAS  Google Scholar 

  25. Colditz, I.G., R.D. Zwahlen, and M. Baggiolini, M. 1990. Neutrophil accumulation and plasma leakage induced in vivo by neutrophil-activating peptide-1.J. Leukocyte Biol.48: 129–137.

    PubMed  CAS  Google Scholar 

  26. Zwahlen, R., A. Walz, and A. Rot. 1993. In vitro and in vivo activity and pathophysiology of human interleukin-8 and related peptides.Int. Rev. Exp. Pathol.34B: 27–42.

    Google Scholar 

  27. Sticherling, M., E. Bornscheuer, J.-M. Schröder, and E. Christophers. 1991. Localization of neutrophilactivating peptide-1/interleukin-8-immunoreactivity in normal and psoriatic skin.J. Invest. Dermatol.96: 26–30.

    Article  PubMed  CAS  Google Scholar 

  28. Nickoloff, B.J., G.D. Karabin, J.M.W.M. Barker, C.E.M. Griffiths, V. Sarma, R.S. Mitra, J.T. Elder, S.L. Kunkel, and V.M. Dixit. 1991. Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-a in psoriasis.Am. J. Pathol.138: 129–140.

    PubMed  CAS  Google Scholar 

  29. Anttila, H.S.I., S. Reitamo, P. Erkko, M. Ceska, B. Moser, and M. Baggiolini. 1992. Interleukin-8 immunoreactivity in the skin of healthy subjects and patients with palmoplantar pustulosis and psoriasis.J. Invest. Dermatol.98: 96–101.

    Article  PubMed  CAS  Google Scholar 

  30. Brennan, F.M., C.O.C. Zachariae, D. Chantry, C.G. Larsen, M. Turner, R.N. Maini, K. Matsushima, and M. Feldmann. 1990. Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells.Eur. J. Immunol.20: 2141–2144.

    Article  PubMed  CAS  Google Scholar 

  31. Seitz, M., B. Dewald, N. Gerber, and M. Baggiolini. 1991. Enhanced production of neutrophilactivating peptide-1/interleukin-8 in rheumatoid arthritis.J. Clin. Invest.87: 463–469.

    Article  PubMed  CAS  Google Scholar 

  32. Koch, A.E., S.L. Kunkel, J.C. Burrows, H.L. Evanoff, G.K. Haines, R.M. Pope, and R.M. Strieter. 1991. Synovial tissue macrophage as a source of the chemotactic cytokine IL-8.J. Immunol.147: 2187–2195.

    PubMed  CAS  Google Scholar 

  33. Miller, E.J., A.B. Cohen, S. Nagao, D. Griffith, RJ. Maunder, T.R. Martin, J.P. Weiner-Kronish, M. Sticherling, E. Christophers, and M.A. Matthay. 1992. Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality.Am. Rev. Respir. Dis.146: 427–432.

    PubMed  CAS  Google Scholar 

  34. Carré, P.C., R.L. Mortenson, T.E. King Jr., P.W. Noble, C.L. Sable, and D.W.H. Riches. 1991. Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis.J. Clin. Invest.88: 1802–1810.

    Article  PubMed  Google Scholar 

  35. Hayes, A.A., T.J. Venaille, A.H. Rose, A.W. Musk, and B.W. Robinson. 1990. Asbestos-induced release of a human alveolar macrophage-derived neutrophil chemotactic factor.Exp. Lung. Res.16: 121–130.

    Article  PubMed  CAS  Google Scholar 

  36. Koch, A.E., S.L. Kunkel, L.A. Harlow, D. Mazarakis, G.K. Haines, M.D. Burdick, R.M. Pope, A. Walz, and R.M. Strieter. 1992. Expression of the novel chemotactic cytokines macrophage inflammatory protein-la and ENA-78 in arthritis.Clin. Res.40: 742. (Abstract)

    Google Scholar 

  37. Koch, A.E., P.J. Polverini, S.L. Kunkel, L.A. Harlow, L.A. DiPietro, V.M. Einer, S.G. Einer, and R.M. Stricter. 1992. Interleukin-8 as a macrophage-derived mediator of angiogenesis.Science258: 1798–1801.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Theodor-Kocher Institute, University of Bern, CH-3000, Bern 9, Switzerland

    Alfred Walz

  2. Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, USA

    Robert M. Strieter & Silvia Schnyder

Authors
  1. Alfred Walz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert M. Strieter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Silvia Schnyder
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Sandoz Research Institute, Vienna, Austria

    I. J. D. Lindley

  2. University of Bath, Bath, UK

    J. Westwick

  3. University of Michigan, Ann Arbor, Michigan, USA

    S. Kunkel

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media New York

About this chapter

Cite this chapter

Walz, A., Strieter, R.M., Schnyder, S. (1993). Neutrophil-Activating Peptide ENA-78. In: Lindley, I.J.D., Westwick, J., Kunkel, S. (eds) The Chemokines. Advances in Experimental Medicine and Biology, vol 351. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2952-1_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2952-1_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6283-8

  • Online ISBN: 978-1-4615-2952-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation