Abstract
Direct and continuous observation of subendocardial (deep myocardial) microcirculation provides essential information on coronary circulation, since cardiac contraction affects subendocardial vessels most vigorously. To achieve this aim, we developed a portable needle-probe video-microscope with a charge-coupled-device (CCD) camera to visualize the subendocardial microcirculation. Images of the subendocardial microcirculation of a porcine beating heart were successfully observed in all cases. The vascular compression by cardiac contraction decreased the diameter of subendocardial arterioles and venules by about 20%.
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Anrep GV, Cruickshank EWH, Downing AC, Subba Rau A. The coronary circulation in relation to the cardiac cycle. Heart 1927; 14: 111–133.
Wiggers CJ. The interplay of coronary vascular resistance and myocardial compression in regulating coronary flow. Circ Res 1954; 2: 271–279.
Gregg DE, Fisher LG. Handbook of Physiology. In: Hamilton WF, Dow P, eds. American Physiological Society. Washington DC 1963; 1517–1584.
Kajiya F, Hiramatsu 0, Mito K, Tadaoka S, Ogasawara Y, Tsujioka K. Evaluation of coronary blood flow by fiber-optic laser Doppler velocimeter. In: Kajiya F, Klassen GA, Spaan JAE, Hoffman JIE, eds. Coronary Circulation, Basic mechanism and clinical relevance, Tokyo: Springer-Verlag 1990; 43–53.
Scaramucci J. Theoremata familiaria viros eruditos consulentia de variis physico-medicis lucubrationibus juxta leges mecanicas: Apud Joannem Baptistam Bustum 1695; 70–81.
Ashikawa K, Kanatsuka H, Suzuki T, Takishima T. Phasic blood flow velocity pattern in epimyocardial microvessels in the beating canine left ventricle. Circ Res 1986; 59: 704–711.
Nellis SH, Liedtke AJ, Whitesell L. Small coronary vessel pressure and diameter in an intact beating rabbit heart using fixed-position and free-motion techniques. Circ Res 1981; 48: 342–353.
Tillmanns H, Ikeda S, Hansen H, Sarma JSM, Fauvel JM, Bing RJ. Microcirculation in the ventricle of the dog and turtle. Circ Res 1974; 34: 561–569.
Chilian WM, Eastham CL, Marcus ML. Microvascular distribution of coronary vascular resistance in beating left ventricle. Am J Physiol 1986; 251: H779–H788.
Kajiya F, Goto M, Yada T, Kimura A, Yamamoto T, Hiramatsu 0, Ogasawara Y, Tsujioka K, Yamamori S, Hosaka S. In-vivo evaluation blood vessels by a new needle type CCD microscope (Abstract). Circulation 1991; 84: 11–271 (Suppl II).
Yada T, Kimura A, Yamamoto T, Hiramatsu 0, Goto M, Ogasawara Y, Tsujioka K, Kajiya F. Nitroglycerin dilates larger coronary venules both in epicardium and endocardium (Abstract). Circulation 1991; 84: 11–673 (Suppl II).
Kanatsuka H, Lamping KG, Eastham CL, Dellsperger KC, Marcus ML. Comparison of the effects of increased myocardial oxygen consumption and adenosine on the coronary microvascular resistance. Circ Res 1989; 65: 1296–1305.
Nellis SH, Whitesell L. Phasic pressures and diameters in small epicardial veins of the unrestrained heart. Am J Physiol 1989; 257: H1056–H1061.
Goto M, Flynn AE, Doucette JW, Jansen CMA, Stork MM, Coggins DL, Muehrcke DD, Husseini WK, Hoffman JIE. Cardiac contraction affects deep myocardial vessels predominantly. Am J Physiol 1991; 261: H1417–H1429.
Judd RM, Levy BI. Effects of barium-induced cardiac contraction on large-and small-vessel intramyocardial blood volume. Circ Res 1991; 68: 217–225.
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© 1993 Springer Science+Business Media New York
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Kajiya, F. et al. (1993). Endocardial Coronary Microcirculation of the Beating Heart. In: Sideman, S., Beyar, R. (eds) Interactive Phenomena in the Cardiac System. Advances in Experimental Medicine and Biology, vol 346. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2946-0_16
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DOI: https://doi.org/10.1007/978-1-4615-2946-0_16
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