Abstract
Members of the dendritic cell (DC) lineage are present in both lymphoid and non-lymphoid organs (Steinman 1991). DC resident in the interstitial connective tissue of non-lymphoid organs are thought to be important passenger cells which sensitise the host T-cells against graft antigens and initiate allograft rejection (Lechler and Batchelor 1982; Austyn and Steinman 1988; see Austyn J. M.). While freshly isolated, mature lymphoid DC are potent inducers of T-dependent immune responses (immunostimulation) (Austyn 1987), Langerhans cells (LC), the immature form of DC in skin, are unable to initiate this primary response, but they develop in culture in the presence of GM-CSF into cells resembling lymphoid DC with potent immunostimulatory capacity (Schuler et al. 1985; Schuler and Steinman 1985; Inaba et al. 1986; Heufler et al. 1987; Witmer-Pack et al. 1987).
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© 1993 Plenum Press, New York
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Rao, A.S., Roake, J.A., Larsen, C.P., Hankins, D.F., Morris, P.J., Austyn, J.M. (1993). Isolation of Dendritic Leukocytes from Non-Lymphoid Organs. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_85
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DOI: https://doi.org/10.1007/978-1-4615-2930-9_85
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