Abstract
The eye and the brain are considered sites of immune privilege(1) and it has been suggested that the lack of MHC Class II antigen presenting cells in neural tissue is responsible for this. However, neural tissue participates in many immune and autoimmune responses both clinically and experimentally(2) and clearly this must involve presentation of autoantigen to antigen specific T cells. In the CNS there is evidence that microglial cells may act as APC(3) during immune responses but, although similar cells occur in the retina, there is as yet no evidence that they may initiate immune responses to autoantigens. Aberrant expression of MHC Class II antigen by ocular cells such as retinal Muller cells, retinal pigment epithelial cells and ciliary body cells has been shown and under certain conditions, each of these cell types can be induced to present antigen albeit weakly(4–9). Conversely in other circumstances such cells may downregulate immune responses.
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© 1993 Plenum Press, New York
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Forrester, J.V., McMenamin, P.G., Liversidge, J., Lumsden, L. (1993). Dendritic Cells and “Dendritic” Macrophages in the Uveal Tract. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_100
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DOI: https://doi.org/10.1007/978-1-4615-2930-9_100
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