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Dendritic Cells: Antigen Presentation, Accessory Function and Clinical Relevance

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Dendritic Cells in Fundamental and Clinical Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 329))

Abstract

Laboratories around the world, many represented here, have now elucidated the broad outlines of the dendritic cell system. Dendritic cells occupy three compartments: a) nonlymphoid tissues such as the Langerhans cells of the skin and the interstitial dendritic cells of lung and heart, b) the circulation especially the veiled cells of the afferent lymph, and c) lymphoid organs primarily the interdigitating cells of the T cell areas and thymic medulla. These pools of dendritic cells are interconnected, since nonlymphoid cells can pick up antigens and migrate into the blood or lymph and to lymphoid organs.

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References

  1. Freudenthal, P. S. & Steinman, R. M. Proc. Natl. Acad. Sci. 87, 7698–7702 (1990).

    Article  CAS  Google Scholar 

  2. Drexhage, H. A. et al. Cell. Tiss. Res. 202, 407–430 (1979).

    Article  CAS  Google Scholar 

  3. Knight, S. C. et al. Eur. J. Immunol. 12, 1057–1060 (1982).

    Article  CAS  Google Scholar 

  4. Pugh, C. W., MacPherson, G. G. & Steer, H. W. J. Exp. Med. 157, 1758–1779 (1983).

    Article  CAS  Google Scholar 

  5. Bujdoso, R. et al J. Exp. Med. 170, 1285–1302 (1989).

    Article  CAS  Google Scholar 

  6. Inaba, K. et al. J. Exp. Med. 172, 631–640 (1990).

    Article  CAS  Google Scholar 

  7. Austyn, J. M. & Larsen, C. P. Transpl. 49, 1–7 (1990).

    Article  CAS  Google Scholar 

  8. Demetris, A. J., Murase, N. & Starzl, T. E. Lancet In Press, (1992).

    Google Scholar 

  9. Schuler, G. & Steinman, R. M. J. Exp. Med. 161, 526–546 (1985).

    Article  CAS  Google Scholar 

  10. Romani, N. et al. J. Exp. Med. 169, 1169–1178 (1989).

    Article  CAS  Google Scholar 

  11. Pure, E. et al. J. Exp. Med. 127, 1459–1469 (1990).

    Article  Google Scholar 

  12. Kampgen, E. et al. Proc. Natl. Acad. Sci. 88, 3014–3018 (1991).

    Article  CAS  Google Scholar 

  13. Romani, N. et al. J. Invest. Dermatol. 93, 600–609 (1989).

    Article  CAS  Google Scholar 

  14. Witmer-Pack, M. D. et al. J. Exp. Med. 166, 1484–1498 (1987).

    Article  CAS  Google Scholar 

  15. Heufler, C., Koch, F. & Schuler, G. J. Exp. Med. 167, 700–705 (1987).

    Article  Google Scholar 

  16. Steinman, R. M., Lustig, D. S. & Cohn, Z. A. J. Exp. Med. 139, 1431–1445 (1974).

    Article  CAS  Google Scholar 

  17. Katz, S. I., Tamaki, K. & Sachs, D. H. Nature 282, 324–326 (1979.

    Article  CAS  Google Scholar 

  18. Barclay, A. N. & Mayrhofer, G. J. Exp. Med. 153, 1666–1671 (1981).

    Article  CAS  Google Scholar 

  19. Hart, D. N. J. & Fabre, J. W. J. Exp. Med. 154, 347–361 (1981).

    Article  CAS  Google Scholar 

  20. Inaba, K. et al. J. Exp. Med. 175, 1157–1167 (1992).

    Article  CAS  Google Scholar 

  21. Breel, M., Mebius, R. E. & Kraal, G. Eur. J. Immunol. 17, 1555–1559 (1987).

    Article  CAS  Google Scholar 

  22. Agger, R. et al. J. Leuk. Biol. 52, 34–42 (1992).

    Article  CAS  Google Scholar 

  23. Crowley, M., Inaba, K. & Steinman, R. M. J. Exp. Med. 172, 383–386 (1990).

    Article  CAS  Google Scholar 

  24. Romani, N. et al. J. Exp. Med. 169, 1153–1168 (1989).

    Article  CAS  Google Scholar 

  25. Steinman, R. M. et al. J. Exp. Med. 152, 1248–1261 (1980).

    Article  CAS  Google Scholar 

  26. Roehm, N. W. et al J. Exp. Med. 160, 679–694 (1984).

    Article  CAS  Google Scholar 

  27. Young, J. W. et al. J. Clin. Invest. 90, 229–237 (1992).

    Article  CAS  Google Scholar 

  28. Cameron, P. U. et al. Exp. Immunol. 88, 1–11 (1992).

    Google Scholar 

  29. Kalter, D. C. et al. J. Immunol. 146, 3396–3404 (1991).

    CAS  PubMed  Google Scholar 

  30. Cameron, P. U. et al. Science In Press (1992).

    Google Scholar 

  31. Lechler, R. I. & Batchelor, J. R. J. Exp. Med. 155, 31–41 (1982).

    Article  CAS  Google Scholar 

  32. Sornasse, T. et al. J. Exp. Med. 175, 15–21 (1992).

    Article  CAS  Google Scholar 

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© 1993 Plenum Press, New York

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Steinman, R.M., Witmer-Pack, M., Inaba, K. (1993). Dendritic Cells: Antigen Presentation, Accessory Function and Clinical Relevance. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_1

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  • DOI: https://doi.org/10.1007/978-1-4615-2930-9_1

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-6272-2

  • Online ISBN: 978-1-4615-2930-9

  • eBook Packages: Springer Book Archive

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