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Intergenerational Factors in Pregnancy Outcome

Implications for Teratology?

  • Chapter
Issues and Reviews in Teratology

Abstract

In general, clinicians and epidemiologists studying reproductive outcomes seem to regard pregnancy merely as an acute situation lasting about 280 days. This common idea places attention primarily on events occurring during pregnancy itself, such as exposure to infectious and chemical agents, physiological and anatomical abnormalities, inadequate diet, abnormal weight gain, pregnancy-induced hypertension, abruptio placenta, and placenta previa. As a result there has been relatively little interest in intrinsic maternal host factors, with some exceptions such as maternal diabetes and other overt maternal chronic diseases. This contrasts with epidemiological studies of various chronic adult diseases, such as hypertension, coronary disease, and various cancers, where the disease is considered at least partly to be related to life-style factors accumulated over a long period of time. There is now substantial evidence that important maternal host factors that influence reproductive outcome are present by the time a woman’s first pregnancy occurs, and that some of these host factors are the end result of long-term processes probably occurring over more than one generation.

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Authors and Affiliations

  1. Departments of Epidemiology and Pediatrics, Maternal and Child Health Program, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, 98195, USA

    Irvin Emanuel

  2. Child Development and Mental Retardation Center, University of Washington, Seattle, Washington, 98195, USA

    Irvin Emanuel

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  1. Children’s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

    Harold Kalter

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Emanuel, I. (1993). Intergenerational Factors in Pregnancy Outcome. In: Kalter, H. (eds) Issues and Reviews in Teratology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2906-4_2

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