Abstract
Historically, the skin was viewed as an impermeable barrier. However, in recent years, it has been increasingly recognized that intact skin can be used as a port for continuous systemic administration of drugs. The first transdermal drug delivery system which has used this new concept is a scopolamine-releasing transdermal therapeutic system (Transderm-ScopĀ® by Ciba) for motion sickness. This was followed by the marketing of several nitroglycerin-releasing systems. Currently, about ten drugs have been either successfully marketed or are under clinical evaluation for transdermal delivery.
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Banga, A.K., Chien, Y.W. (1993). Dermal Absorption of Peptides and Proteins. In: Audus, K.L., Raub, T.J. (eds) Biological Barriers to Protein Delivery. Pharmaceutical Biotechnology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2898-2_8
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DOI: https://doi.org/10.1007/978-1-4615-2898-2_8
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