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Translation Control by Adenovirus Virus-Associated RNA I

  • Chapter
Translational Regulation of Gene Expression 2

Abstract

Adenoviruses were first isolated by Rowe and co-workers from human adenoid tissues—hence the name adenoviruses. These are nonenveloped DNA viruses, composed of only DNA and proteins, and are widespread in nature. Forty-one of the 93 strains identified so far are of human origin, while the rest have been isolated from monkeys, dogs, cattle, rodents, and birds.1–3 Clinical studies have shown that these viruses can cause a variety of diseases in humans, most of which involve the respiratory tract, the eye, and the gastrointestinal tract. For the most part, these infections lead to self-limited illnesses or latent persistent infections and are usually followed by complete recovery. Adenoviruses can maintain inapparent infections within host animals for months or even years. Lymphoid cells may serve as reservoirs for these persistent infections. Several members of this group can also induce malignant tumors in newborn rodents and therefore adenoviruses are classified as members of the DNA tumor virus group. All the members of this group tested so far have been shown to transform rodent cells in culture.4 Despite their tumorigenic potential in experimental models, these viruses have not been shown to be tumorigenic in humans. Adenoviruses can be grown to high titers in a variety of cultured mammalian cells. Human cells of epithelial origin are best suited for growing human adenoviruses. Because of the small size of their genome, the ease with which they can be grown in rapidly growing cultured cells, and their ability to transform rodent cells in vitro, adenoviruses have served as important model systems to study the regulation of eukaryotic gene expression and virus-host-cell interactions.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, and Robert H. Lurie Cancer Center, Northwestern University Medical School, Chicago, Illinois, 60611, USA

    Bayar Thimmapaya, Ghanashyam D. Ghadge, Prithi Rajan & Sathyamangalam Swaminathan

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  1. Bayar Thimmapaya
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  2. Ghanashyam D. Ghadge
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  3. Prithi Rajan
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  4. Sathyamangalam Swaminathan
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Editors and Affiliations

  1. Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106, USA

    Joseph Ilan

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Thimmapaya, B., Ghadge, G.D., Rajan, P., Swaminathan, S. (1993). Translation Control by Adenovirus Virus-Associated RNA I. In: Ilan, J. (eds) Translational Regulation of Gene Expression 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2894-4_10

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