Abstract
Dopamine content is elevated in the carotid body of newborn rats and is associated with a blunted chemoreflex during the first few days of life (Hertzberg & Hellstrom, 1990). The purpose of this study was to establish the presence of mRNA coding for the D2-dopamine receptor (D2-R) in the carotid body and petrosal ganglia in the cat, and compare the levels of expression of D2-R mRNA in these tissues at two stages during development. We hypothesized that D2-R mRNA would be present in both the carotid body and petrosal ganglia. Because of the blunted chemoreflex observed at birth, we further hypothesized that there would be a greater expression of the mRNA coding for the D2-R in the petrosal ganglia and less in the carotid body at birth than at 14 weeks postnatal age.
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References
Czyzky-Krzeska, M.F., Lawson, E.E., &Millhorn, D.E. (1992). Expression of D2 dopamine receptor mRNA in the arterial chemoreceptor afferent pathway. J. Auton. Nerv. Syst. 41:31–40.
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© 1994 Springer Science+Business Media New York
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Gauda, E.B., Shirahata, M., Fitzgerald, R.S. (1994). D2-Dopamine Receptor mRNA in the Carotid Body and Petrosal Ganglia in the Developing Cat. In: O’Regan, R.G., Nolan, P., McQueen, D.S., Paterson, D.J. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 360. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2572-1_56
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DOI: https://doi.org/10.1007/978-1-4615-2572-1_56
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