Abstract
Iron is essential for the growth of most cells since it participates in many key metabolic processes. However, under current environmental conditions, where oxygen is plentiful, most iron exists in the oxidized ferric or Fe(III) form. Ferric iron readily precipitates as highly insoluble ferric hydroxides at neutral pH, and these are not readily utilized by cells. The other biologically important oxidation state of iron is Fe(II), the ferrous form. Ferrous iron is much more soluble at neutral pH than ferric iron, but in the presence of oxygen it is efficiently oxidized to Fe(III). Thus, if organisms are to acquire enough iron to meet their metabolic requirements, they must evolve strategies for obtaining insoluble ferric iron from the environment.
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References
Beinfait, F., 1987, Biochemical basis of iron efficiency reactions in plants, in: “Iron Transport in Microbes, Plants and Animals,” G. Winkelmann, D. van der Helm, and J.B. Neilands, eds, VCH Verlagsgesellschaft, Weinheim.
Crane, F.L., Roberts, H., Linnane, A.W., and Low, H., 1982, Transmembrane ferricyanide reduction by cells of the yeast Saccharomyces cerevisiae, J Bioenerg Biomembr. 14: 191.
Dancis, A., Klausner, R.D., Hinnebusch, A.G., and Barriocanal, J.G., 1990, Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae, Mol Cell Biol. 10: 2294.
Dancis, A., Roman, D.G., Anderson, G.J., Hinnebusch, A.G., and Klausner, R.D., 1992, Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron, Proc Natl Acad Sci USA. 89: 3869.
de Jong, G., van Dijk, J.P., and van Eijk, H.G., 1990, The biology of transferrin, Clin Chim Acta 190: 1.
Eide, D.J., Bridgham, J.T., Zhao, Z., and Mattoon, J.R., 1993, The vacuolar ATPase of Saccharomyces cerevisiae is required for efficient copper detoxification, mitochondrial function, and iron metabolism, Mol Gen Genet. In press.
Eide, D., Davis-Kaplan, S., Jordan, I., Sipe, D., and Kaplan, J., 1992, Regulation of iron uptake in Saccharomyces cerevisiae. The ferrireductase and Fe(II) transporter are regulated independently, J Biol Chem. 267: 20774.
Eide, D., and Guarente, L., 1992, Increased dosage of a transcriptional activator gene enhances iron-limited growth of Saccharomyces cerevisiae, J Gen Microbiol. 138: 347.
Emery, T., 1987, Reductive mechanisms of iron assimilation, in: “Iron Transport in Microbes, Plants and Animals,” G. Winkelmann, D. van der Helm, and J.B. Neilands, eds, VCH Verlagsgesellschaft, Weinheim.
Estruch, F., and Carlson, M., 1990, Increased dosage of the MSN1 gene restores invertase expression in yeast mutants defect in the SNF1 protein kinase, Nucl Acids Res. 18: 6959.
Fuhrmann, G-F., and Rothstein, A., 1968, The transport of Zn2+, Co2+ and Ni2+ into yeast cells, Biochim Biophys Acta 163: 325.
Karplus, P.A., Daniels, M.J., Herriot, J.R., 1991, Atomic structure of ferredoxin-NADP+ reductase: prototype for a structurally novel flavoenzyme family, Science 251: 60.
Lesuisse, E., Crichton, R.R., and Labbe, P., 1990, Iron-reductases in the yeast Saccharomyces cerevisiae, Biochim Biophys Acta 1038: 253.
Lesuisse, E., Horion, B., Labbe, P., and Hilger, F., 1991, The plasma membrane ferrireductase activity of Saccharomyces cerevisiae is partially controlled by cyclic AMP, Biochem J. 280: 545.
Lesuisse, E., and Labbe, P., 1989, Reductive and non-reductive mechanisms of iron assimilation by the yeast Saccharomyces cerevisiae, J Gen Microbiol. 135: 257.
Lesuisse, E., Raguzzi, F., and Crichton, R.R., 1987, Iron uptake by the yeast Saccharomyces cerevisiae: involvement of a reduction step, J Gen Microbiol 133: 3229.
Lesuisse, E., Simon, M., Klein, R., and Labbe, P., 1992, Excretion of anthranilate and 3-hydroxyanthranilate by Saccharomyces cerevisiae: relationship to iron metabolism, J Gen Microbiol. 138: 85.
Melnick, L., and Sherman, F., 1990, Nucleotide sequence of the COR region: a cluster of six genes in the yeast Saccharomyces cerevisiae, Gene 87: 157.
Nielands, J.B., Konopka, K., Schwyn, B., Coy, M., Francis, R.T., Paw, B.H., and Bagg, A., 1987, Comparative biochemistry of microbial iron assimilation, in: “Iron Transport in Microbes, Plants and Animals,” G. Winkelmann, D. van der Helm, and J.B. Neilands, eds, VCH Verlagsgesellschaft, Weinheim.
Nunez, M.T., Cole, E.S., and Glass, J., 1983, The reticulocyte plasma membrane pathway of iron uptake as determined by the mechanism of α, α’-dipyridyl inhibition, J Biol Chem. 258: 1146.
Raguzzi, F., Lesuisse, E., and Crichton, R.R., 1988, Iron storage in Saccharomyces cerevisiae, FEBS Lett. 231: 253.
Raja, K.B., Simpson, T.J., and Peters, T.J., 1992, Investigation of a role for reduction in ferric iron uptake by mouse duodenum, Biochim Biophys Acta 1135: 141.
Roman, D.G., Dancis, A., Anderson, G.J., and Klausner, R.D., 1993, The fission yeast ferric reductase gene frp1 + is required for ferric iron uptake and encodes a protein that is homologous to the gp91 -phox subunit of the human NADPH phagocyte oxidoreductase, Mol Cell Biol. 13: 4342.
Segal, A.W., and Abo, A., 1993, The biochemical basis of the NADPH oxidase of phagocytes, Trends Biochem Sci. 18: 43.
Segal, A.W., West, I., Wientjes, F., Nugent, J.H.A., Chavan, A.J., Haley, B., Garcia, R.C., Rosen, H., and Scrace, G., 1992, Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes, Biochem J. 284: 781.
Schnell, N., and Entian, K-D, 1991, Identification and characterization of a Saccharomyces cerevisiae gene (PAR1) conferring resistance to iron chelators, Eur J Biochem. 200: 487.
Schnell, N., Krems, B., and Entian, K-D., 1992, The PAR1 (YAP/SNQ3) gene of Saccharomyces cerevisiae, a c-jun homologue, is involved in oxygen metabolism, Curr Genet. 21: 269.
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Anderson, G.J., Dancis, A., Roman, D.G., Klausner, R.D. (1994). Ferric Iron Reduction and Iron Uptake in Eucaryotes: Studies with the Yeasts. In: Hershko, C., Konijn, A.M., Aisen, P. (eds) Progress in Iron Research. Advances in Experimental Medicine and Biology, vol 356. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2554-7_9
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DOI: https://doi.org/10.1007/978-1-4615-2554-7_9
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