Abstract
The detection of a soluble form of the transferrin receptor (TfR) in human sera has been a major advance in hematological and ferrobiological research. Since the predominant expression of TfR is on the erythroid colony forming unit and late erythroid progenitors, the serum TfR would be expected to provide a quantitative measure of the size of the late progenitor pool. This has been confirmed by its excellent correlation with the size of this pool as determined ferrokinetically (Huebers et al. 1990). The other determinant of tissue receptor mass is the cellular iron content. A raised serum TfR is the earliest biochemical indicator of depletion of the functional iron pool (Skikne et al. 1990) and the most reliable indicator of iron deficiency in pregnancy where other measurements, including hemoglobin concentration, serum iron, percentage saturation, and serum ferritin, are often not helpful (Carriaga et al. 1991). Serum TfR is the only non-invasive measure to reliably distinguish the anemia of chronic disease from that of iron deficiency (Ferguson et al. 1992). Given these attributes, this measurement is becoming a crucial component in the evaluation of population iron nutriture (Cook et al. 1992; Cook et al. 1993a; Cook et al. 1993b).
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© 1994 Springer Science+Business Media New York
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Baynes, R.D., Shih, Y.J., Cook, J.D. (1994). Mechanism of Production of the Serum Transferrin Receptor. In: Hershko, C., Konijn, A.M., Aisen, P. (eds) Progress in Iron Research. Advances in Experimental Medicine and Biology, vol 356. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2554-7_7
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