Abstract
Inflammation substantially alters iron metabolism. The plasma level of iron falls, along with that of transferrin. Conversely, the quantity of ferritin in the plasma increases by two- to three-fold, in many instances. Chronic inflammation, such as that which accompanies rheumatoid arthritis, for instance, is associated with a low-grade anemia. This “anemia of chronic disease” results, in part, from impaired delivery of iron to bone marrow normoblasts.
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Rogers, J., Lacroix, L., Durmowitz, G., Kasschau, K., Andriotakis, J., Bridges, K.R. (1994). The Role of Cytokines in the Regulation of Ferritin Expression. In: Hershko, C., Konijn, A.M., Aisen, P. (eds) Progress in Iron Research. Advances in Experimental Medicine and Biology, vol 356. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2554-7_14
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DOI: https://doi.org/10.1007/978-1-4615-2554-7_14
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