Abstract
In the small intestine of conventionally reared mice the number of IgA producing plasma cells is greater then the total number of plasma cells that can be found in other lymphoid tissues, l The produced IgA is thought to play an important role in the humoral protection against pathogens that might invade the animal at mucosal surfaces.2 Most studies showing the role of IgA in protection involve oral or intraperitoneal immunization and subsequent analysis of antigen-specific IgA.3 The interaction between the normal gut flora and spontaneously produced IgA, however, is much less clear. In mice that are kept under germfree conditions a very drastic reduction in the total number of IgA producing cells is observed,4 suggesting an inductive role of the normal microflora for the IgA production. The specificity repertoire of these spontaneous IgA producing cells is largely unknown.
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Bos, N.A. et al. (1994). Analysis of Iga-Producing Hybridomas Derived from Peritoneal Bl Cells. In: Heinen, E., Defresne, M.P., Boniver, J., Geenen, V. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 355. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2492-2_45
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DOI: https://doi.org/10.1007/978-1-4615-2492-2_45
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