Abstract
Problem wounds are wounds that fail to heal after standard treatment e. g. surgical necrotic tissue debridement, absces drainage, vascular reconstruction etc. Since problem wounds are characterised by hypoxia, hyperbaric oxygen therapy (HBO) is used for treatment, especially in patients with peripheral arterial occlusive disease (Visona et al. 1989). Several authors (Bird and Telfer, 1965; Reich et al., 1970, Hammerlund et al., 1988) have studied the effects of normobaric and hyperbaric oxygen breathing on forearm blood flow in healthy persons and reported a reduction in blood flow apparently counteracting the benefit of hyperoxygenation. On the other hand during hyperoxygenation transcutaneous PO2 values of over 900 mm Hg have been reported (Dooley and Mehm, 1990, Mathieu et al.,1990) indicating high concentrations of available molecular oxygen in the dermal microcirculation. Intravital capillary microscopy of the nailfold provides information about capillary nutritional blood flow in patients with compromised skin oxygenation (Jacobs et al. 1992). It is not known in what way HBO affects skin capillary nutritional blood flow and how intravital nailfold microscopy can assess the state of hyperoxygenation. The aim of this study was to evaluate the influence of HBO on microcirculatory skin blood flow in healthy volunteers by means of intravital microscopy.
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van der Kleij, A.J., Vink, H., Henny, C.P., Bakker, D.J., Spaan, J.A.E. (1994). Red Blood Cell Velocity in Nailfold Capillaries during Hyperbaric Oxygenation. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_23
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DOI: https://doi.org/10.1007/978-1-4615-2468-7_23
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