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Antiribosomal Antibodies in SLE, Infection, and Following Deliberate Immunization

  • Chapter
Immunobiology of Proteins and Peptides VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 347))

Abstract

It has long been known that patients with systemic lupus erythematosus (SLE) and related diseases have, in addition to antinuclear antibodies (ANA), autoantibodies directed against cytoplasmic constituents1,2. In SLE, these antibodies are predominantly directed against ribosomes3–5. In 1985, two groups of investigators independently identified the ribosomal P proteins as the major protein antigens recognized by anti-ribosomal antibodies in SLE6,7. In addition, evidence for antibodies that bound to ribosomal RNA (rRNA) was presented6,7. Although antibodies against other ribosomal proteins, S108, L59, and L1210 have been detected, these are present in a very small number of patients with SLE.

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Author information

Authors and Affiliations

  1. The Hospital for Special Surgery, Cornell University Medical Center, New York, NY, USA

    Keith B. Elkon

  2. University of Sao Paolo, Sao Paulo, Brazil

    Eloisa Bonfa

  3. Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ, 07110, USA

    Herbert Weissbach & Nathan Brot

Authors
  1. Keith B. Elkon
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  2. Eloisa Bonfa
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  3. Herbert Weissbach
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  4. Nathan Brot
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Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    M. Zouhair Atassi

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© 1994 Springer Science+Business Media New York

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Elkon, K.B., Bonfa, E., Weissbach, H., Brot, N. (1994). Antiribosomal Antibodies in SLE, Infection, and Following Deliberate Immunization. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides VII. Advances in Experimental Medicine and Biology, vol 347. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2427-4_9

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  • DOI: https://doi.org/10.1007/978-1-4615-2427-4_9

  • Publisher Name: Springer, Boston, MA

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