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Assembly of the Peroxisomal Membrane

  • Chapter
Membrane Biogenesis

Part of the book series: Subcellular Biochemistry ((SCBI,volume 22))

Abstract

Peroxisomes are found in virtually all eukaryotic cells ranging from eukaryotic microorganisms to plants and animals. In addition to a variety of other enzymes, peroxisomes contain hydrogen peroxide-producing oxidases and catalase that decomposes hydrogen peroxide. The name peroxisome refers to the organelle’s role in the production and disposition of hydrogen peroxide (de Duve and Bau-dhuin, 1966).

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References

  • Alexson, S. E. H., Fujiki, Y., Shio, H., and Lazarow, P. B., 1985, Partial disassembly of peroxisomes, J. Cell Biol. 101:294–305.

    Article  CAS  PubMed  Google Scholar 

  • Aman, R. A., and Wang, C. C., 1987, Identification of two integral glycosomal membrane proteins in Trypanosoma brucei, Mol. Biochem. Parasitol. 25:83–92.

    Article  CAS  PubMed  Google Scholar 

  • Appelkvist, E.-L., 1987, Dolichol biosynthesis in rat liver peroxisomes, Acta Chem. Scand. B41:73–75.

    Article  CAS  Google Scholar 

  • Appelkvist, E.-L., and Daliner, G., 1987, Dolichol metabolism and peroxisomes, in Peroxisomes in Biology and Medicine (H. D. Fahimi and H. Sies, eds.), pp. 53–66, Springer-Verlag, Berlin, Heidelberg.

    Chapter  Google Scholar 

  • Appelkvist, E.-L., and Kalén, A., 1989, Biosynthesis of dolichol by rat liver peroxisomes, Eur. J. Biochem. 185:503–509.

    Article  CAS  PubMed  Google Scholar 

  • Appelkvist, E.-L., Brunk, U., and Dallner, G., 1981, Isolation of peroxisomes from rat liver using sucrose and Percoll gradients, J. Biochem. Biophys. Methods 5:203–217.

    Article  CAS  PubMed  Google Scholar 

  • Appelkvist, E.-L., Reinhart, M., Fischer, R., Billheimer, J., and Dallner, G., 1990, Presence of individual enzymes of cholesterol biosynthesis in rat liver peroxisomes, Arch. Biochem. Bio-phys. 282:318–325.

    Article  CAS  Google Scholar 

  • Balfe, A., Hoefler, G., Chen, W. W., and Watkins, P. A., 1990, Aberrant subcellular localization of peroxisomal 3-ketoacyl-CoA thiolase in the Zellweger syndrome and rhizomelic chondrodys-plasia punctata, Pediair. Res. 27:304–310.

    Article  CAS  Google Scholar 

  • Ballas, L. M., Lazarow, P. B., and Bell, R. M., 1984, Glycerolipid synthetic capacity of rat liver peroxisomes, Biochim. Biophys. Acta 795:297–300.

    Article  CAS  PubMed  Google Scholar 

  • Beevers, H., 1982, Glyoxysomes in higher plants, Ann. NY Acad. Sci. 386:243–251.

    Article  CAS  Google Scholar 

  • Beevers, H., and Gonzalez, E., 1987, Proteins and phospholipids of glyoxysomal membranes from castor bean, Methods Enzymol. 148:526–532.

    Article  CAS  Google Scholar 

  • Bell, R. M., and Coleman, R. A., 1980, Enzymes of glycerolipid synthesis in eukaryotes, Annu. Rev. Biochem. 49:459–487.

    Article  CAS  PubMed  Google Scholar 

  • Bishop, J. E., Salem, M., and Hajra, A. K., 1982, Topographical distribution of lipid biosynthetic enzymes on peroxisomes (microbodies), Ann. NY Acad. Sci. 386:411–413.

    Article  CAS  Google Scholar 

  • Bodnar, A. G., and Rachubinski, R. A., 1990, Cloning and sequence determination of cDNA encoding a second rat liver peroxisomal 3-ketoacyl-CoA thiolase, Gene 91:193–199.

    Article  CAS  PubMed  Google Scholar 

  • Bodnar, A. G., and Rachubinski, R. A., 1991, Characterization of the integral membrane Polypeptides of rat liver peroxisomes isolated from untreated and clofibrate-treated rats, Biochem. Cell Biol. 69:499–508.

    Article  CAS  PubMed  Google Scholar 

  • Bronfman, M., Inestrosa, N. C., Nervi, F. O., and Leighton, F., 1984, Acyl-CoA synthetase and the peroxisomal enzymes of β-oxidation in human liver, Biochem. J. 224:709–720.

    CAS  PubMed  Google Scholar 

  • Brul, S., Westerfeld, A., Strijland, A., Wanders, R. J. A., Schram, A. W., Heymans, H. S. A., Schutgens, R. B. H., van den Bosch, H., and Tager, J. M., 1988, Genetic heterogeneity in the cerebrohepatorenal (Zellweger) syndrome and other inherited disorders with a generalized impairment of peroxisomal functions: A study using complementation analysis, J. Clin. Invest. 81:1710–1715.

    Article  CAS  PubMed  Google Scholar 

  • Burdett, K., Larkins, L. K., Das, A. K., and Hajra, A. K., 1991, Peroxisomal localization of acyl-coenzyme A reductase (long chain alcohol forming) in guinea pig intestine mucosal cells, J. Biol. Chem. 266:12201–12206.

    CAS  PubMed  Google Scholar 

  • Cerdan, S., Künnecke, B., Dölle, A., and Seelig, J., 1988, In situ metabolism of 1,ω medium chain dicarboxylic acids in the liver of intact rats as detected by 13C and 1H NMR, J. Biol. Chem. 263:11664–11674.

    CAS  PubMed  Google Scholar 

  • Chapman, K. D., and Trelease, R. N., 1991, Acquisition of membrane lipids by differentiating glyoxysomes: Role of lipid bodies, J. Cell Biol. 115:995–1007.

    Article  CAS  PubMed  Google Scholar 

  • Chen, N., Crane, D. I., and Masters, C., 1988, Analysis of the major integral membrane proteins of peroxisomes from mouse liver, Biochim. Biophys. Acta 945:135–144.

    Article  CAS  PubMed  Google Scholar 

  • Crane, D. I., and Masters, C. J., 1986, The effect of Clofibrate on the phospholipid composition of the peroxisomal membrane in mouse liver, Biochim. Biophys. Acta 876:256–263.

    Article  CAS  PubMed  Google Scholar 

  • Datta, S. C., Ghosh, M. K., and Hajra, A. K., 1990, Purification and properties of acyl/alkyl dihydroxyacetone-phosphate reductase from guinea pig liver peroxisomes, J. Biol. Chem. 265:8268–8274.

    CAS  PubMed  Google Scholar 

  • Declercq, P. E., Haagsman, H. P., Van Veldhoven, P., Debeer, L. J., van Golde, L. M. G., and Mannaerts, G. P., 1984, Rat liver dihydroxyacetone-phosphate acyltransferases and their contribution to glycerolipid synthesis, J. Biol. Chem. 259:9064–9075.

    CAS  PubMed  Google Scholar 

  • de Duve, C., and Baudhuin, P., 1966, Peroxisomes (microbodies and related particles), Physiol. Rev. 46:323–357.

    PubMed  Google Scholar 

  • de Duve, C., Pressman, B. C., Gianetto, R., Wattiaux, R., and Appelmans, F., 1955, Tissue fractionation studies. 6: Intracellular distribution patterns of enzymes in rat liver tissue, Biochem. J. 60:604–617.

    Google Scholar 

  • delValle, R., Soto, U., Necochea, C., and Leighton, F., 1988, Detection of an ATPase activity in rat liver peroxisomes, Biochem. Biophys. Res. Commun. 156:1353–1359.

    Article  CAS  Google Scholar 

  • Donaldson, R. P., Tolbert, N. E., and Schnarrenberger, C., 1972, A comparison of microbody membranes with microsomes and mitochondria from plant and animal tissue, Arch. Biochem. Biophys. 152:199–215.

    Article  CAS  PubMed  Google Scholar 

  • Donaldson, R. P., Tblly, R. E., Young, O. E., and Beevers, H., 1981, Organelle membranes from germinating castor bean endosperm. II: Enzymes, cytochromes and permeability of the glyoxy-some membrane, Plant Physiol. 67:21–25.

    Article  CAS  PubMed  Google Scholar 

  • Douma, A. C., Veenhuis, M., Suiter, G. J., and Harder, W., 1987, A proton-translocating adenosine triphosphatase is associated with the peroxisomal membrane of yeasts, Arch. Microbiol. 147:42–47.

    Article  CAS  PubMed  Google Scholar 

  • Douma, A. C., Veenhuis, M., Suiter, G. J., Waterman, H. R., Verheyden, K., Mannaerts, G. P., and Harder, W., 1990, Permeability properties of peroxisomal membranes from yeasts, Arch. Microbiol. 153:490–495.

    Article  CAS  PubMed  Google Scholar 

  • Dreyer, C., Krey, G., Keller, H., Givel, F., Helftenbein, G., and Wahli, W., 1992, Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors, Cell 68:879–887.

    Article  CAS  PubMed  Google Scholar 

  • Dunn, W. A., Jr., 1990, Studies on the mechanisms of autophagy: Maturation of the autophagic vacuole, J. Cell Biol. 110:1935–1945.

    Article  CAS  PubMed  Google Scholar 

  • Erdmann, R., Wiebel, F. F., Flessau, A., Rytka, J., Beyer, A., Fröhlich, K.-U., and Kunau, W.-H., 1991, PAS1, a yeast gene required for peroxisome biogenesis, encodes a member of a novel family of putative ATPases, Cell 64:499–510.

    Article  CAS  PubMed  Google Scholar 

  • Evans, W. H., 1982, Subcellular membranes and isolated organelles: Preparative techniques and criteria for purity, Techniques Lipid Membr. Biochem. B407a:l–46.

    Google Scholar 

  • Fujiki, Y., and Lazarow, P. B., 1985, Post-translational import of fatty acyl-CoA oxidase and catalase into peroxisomes of rat liver in vitro, J. Biol. Chem. 260:5603–5609.

    CAS  PubMed  Google Scholar 

  • Fujiki, Y., Fowler, S., Shio, H., Hubbard, A. L., and Lazarow, P. B., 1982, Polypeptide and phospholipid composition of the membrane of rat liver peroxisomes: Comparison with endo-plasmic reticulum and mitochondrial membranes, J. Cell Biol. 93:103–110.

    Article  CAS  PubMed  Google Scholar 

  • Fujiki, Y., Rachubinski, R. A., and Lazarow, P. B., 1984, Synthesis of a major integral membrane Polypeptide of rat liver peroxisomes on free polysomes, Proc. Natl. Acad. Sci. USA 81:7127–7131.

    Article  CAS  PubMed  Google Scholar 

  • Fujiki, Y., Rachubinski, R. A., Mortensen, R. M., and Lazarow, P. B., 1985, Synthesis of 3-ketoacyl-CoA thiolase of rat liver peroxisomes on free polyribosomes as a larger precursor: Induction of thiolase mRNA activity by Clofibrate, Biochem. J. 226:697–704.

    CAS  PubMed  Google Scholar 

  • Fung, K., and Clayton, C., 1991, Recognition of a peroxisomal tripeptide entry signal by glyco-somes of Trypanosoma brucei, Mol. Biochem. Parasitol. 45:261–264.

    Article  CAS  PubMed  Google Scholar 

  • Gärtner, J., Chen, W. W., Kelley, R. I., Mihalik, S. J., and Moser, H. W., 1991, The 22-kD peroxisomal integral membrane protein in Zellweger syndrome—presence, abundance, and association with a peroxisomal thiolase precursor protein, Pediatr. Res. 29:141–146.

    Article  PubMed  Google Scholar 

  • Gärtner, J., Moser, H., and Valle, D., 1992, Mutations in the 70 K peroxisomal membrane protein gene in Zellweger syndrome, Nature Genet. 1:16–25.

    Article  PubMed  Google Scholar 

  • Ghosh, M. K., and Hajra, A. K., 1986a, A rapid method for the isolation of peroxisomes from rat liver, Anal. Biochem. 159:169–174.

    Article  CAS  PubMed  Google Scholar 

  • Ghosh, M. K., and Hajra, A. K., 1986b, Subcellular distribution and properties of acyl/alkyl dihydroxyacetone phosphate reductase in rodent liver, Arch. Biochem. Biophys. 245:523–530.

    Article  CAS  PubMed  Google Scholar 

  • Gietl, C., 1990, Glyoxysomal malate dehydrogenase from watermelon is synthesized with an amino-terminal transit peptide, Proc. Natl. Acad. Sci. USA 87:5113–5711.

    Article  Google Scholar 

  • Goldman, B. M., and Blobel, G., 1978, Biogenesis of peroxisomes: Intracellular site of synthesis of catalase and uricase, Proc. Natl. Acad. Sci. USA 75:5066–5070.

    Article  CAS  PubMed  Google Scholar 

  • Gonzalez, E., Brush, M. D., and Maeshima, M., 1987, The alkaline lipase of the glyoxysomal membrane is a glycoprotein, in Peroxisomes in Biology and Medicine (H. D. Fahimi and H. Sies, eds.), pp. 194–198, Springer-Verlag, Berlin, Heidelberg.

    Chapter  Google Scholar 

  • Goodman, J. M., Maher, J., Silver, P. A., Pacifico, A., and Sanders, D., 1986, The membrane proteins of the methanol-induced peroxisome of Candida boidinii: Initial characterization and generation of monoclonal antibodies, J. Biol. Chem. 261:3464–3468.

    CAS  PubMed  Google Scholar 

  • Goodman, J. M., Trapp, S. B., and Huang, H., 1990, Peroxisomes induced in Candida boidinii by methanol, oleic acid and D-alanine vary in metabolic function but share common integral membrane proteins, J. Cell Sci. 97:193–204.

    CAS  PubMed  Google Scholar 

  • Gorgas, K., 1984, Peroxisomes in sebaceous glands. V: Complex peroxisomes in the mouse prepu-tial gland: Serial sectioning and three dimensional reconstruction studies, Anat. Embryol. 169:261–270.

    Article  CAS  PubMed  Google Scholar 

  • Gorgas, K., 1985, Serial sectioning analysis of mouse hepatic peroxisomes, Anat. Embryol. 172:21–32.

    Article  CAS  PubMed  Google Scholar 

  • Gould, S. J., Keller, G.-A., and Subramani, S., 1988, Identification of peroxisomal targeting signals located at the carboxy terminus of four peroxisomal proteins, J. Cell Biol. 107:897–905.

    Article  CAS  PubMed  Google Scholar 

  • Gould, S. J., Keller, G.-A., Hosken, N., Wilkinson, J., and Subramani, S., 1989, A conserved tripeptide sorts proteins to peroxisomes, J. Cell Biol. 108:1657–1664.

    Article  CAS  PubMed  Google Scholar 

  • Gould, S. J., Keller, G.-A., Schneider, M., Howell, S. H., Garrard, L. J., Goodman, J. M., Distel, B., Tabak, H., and Subramani, S., 1990b, Peroxisomal protein import is conserved between yeast, plants, insects and mammals, EMBO J. 9:85–90.

    CAS  PubMed  Google Scholar 

  • Gould, S. J., Krisans, S., Keller, G.-A., and Subramani, S., 1990a, Antibodies directed against the peroxisomal targeting signal of firefly luciferase recognize multiple mammalian peroxisomal proteins, J. Cell Biol. 110:27–34.

    Article  CAS  PubMed  Google Scholar 

  • Hajra, A. K., and Bishop, J. E., 1982, Glycerolipid biosynthesis in peroxisomes via the acyldihydroxyacetone phosphate pathway, Ann. NY Acad. Sci. 386:170–181.

    Article  CAS  PubMed  Google Scholar 

  • Hajra, A. K., Burke, C. L., and Jones, C. L., 1979, Subcellular localization of acyl-coenzyme A: Dihydroxyacetone phosphate acyltransferase in rat liver peroxisomes (microbodies), J. Biol. Chem. 254:10896–10900.

    CAS  PubMed  Google Scholar 

  • Hajra, A. K., and Wu, D., 1985, Preparative isolation of peroxisomes from liver and kidney using metrizamide density gradient centrifugation in a vertical rotor, Anal. Biochem. 148:233–244.

    Article  CAS  PubMed  Google Scholar 

  • Hardeman, D., Versantvoort, C., van den Brink, J. M., and van den Bosch, H., 1990, Studies on peroxisomal membranes, Biochim. Biophys. Acta 1027:149–154.

    Article  CAS  PubMed  Google Scholar 

  • Haiti, F.-U., and Just, W. W., 1987, Integral membrane Polypeptides of rat liver peroxisomes: Topology and response to different metabolic states, Arch. Biochem. Biophys. 255:109–119.

    Article  Google Scholar 

  • Hartl, F.-U., Just, W. W., Köster, A., and Schimassek, H., 1985, Improved isolation and purification of rat liver peroxisomes by combined rate zonal and equilibrium density centrifugation, Arch. Biochem. Biophys. 237:124–134.

    Article  CAS  PubMed  Google Scholar 

  • Hashimoto, T., Kuwabara, T., Usuda, N., and Nagata, T., 1986, Purification of membrane Polypeptides of rat liver peroxisomes, J. Biochem. 100:301–310.

    CAS  PubMed  Google Scholar 

  • Heinemann, P., and Just, W. W., 1992, Peroxisomal protein import: In vivo evidence for a novel translocation competent compartment, FEBS Lett. 300:179–182.

    Article  CAS  PubMed  Google Scholar 

  • Heupel, R., Markgraf, T., Robinson, D. G., and Heldt, H. W., 1991, Compartmentation studies on spinach leaf peroxisomes: Evidence for channeling of phosphorespiratory metabolites in peroxisomes devoid of intact boundary membrane, Plant Physiol. 96:971–979.

    Article  CAS  PubMed  Google Scholar 

  • Heymans, H. S. A., Schutgens, R. B. H., Tan, R., van den Bosch, H., and Borst, P., 1983, Severe plasmalogen deficiency in tissues of infants without peroxisomes (Zellweger syndrome), Nature 306:69–70.

    Article  CAS  PubMed  Google Scholar 

  • Hijikata, M., Ishii, N., Kagamiyama, H., Osumi, T., and Hashimoto, T., 1987, Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase, J. Biol. Chem. 262:8151–8158.

    CAS  PubMed  Google Scholar 

  • Höhfeld, J., Veenhuis, M., and Kunau, W.-H., 1991, PAS3, a Saccharomyces cerevisiae gene encoding a peroxisomal integral membrane protein essential for peroxisome biogenesis, J. Cell Biol. 114:1167–1178.

    Article  PubMed  Google Scholar 

  • Höhfeld, J., Mertens, D., Wiebel, F. F., and Kunau, W. H., 1992, Defining components required for peroxisome assembly in Saccharomyces cerevisiae, in Membrane Biogenesis and Protein Targeting, New Comprehensive Biochemistry Series, Vol. 22 (W. Neupert and R. Lyll, eds.), pp. 185–207, Elsevier Science Publishing, New York.

    Google Scholar 

  • Horie, S., Das, A. K., and Hajra, A. K., 1992, Alkyldihydroxyacetonephosphate synthase from guinea pig liver peroxisomes, Methods Enzymol. 209:385–390.

    Article  CAS  PubMed  Google Scholar 

  • Hruban, Z., and Rechcigl, M., Jr., 1969, Microbodies and related particles, in Int. Rev. Cytol. (Suppl. 1) Academic Press, New York.

    Google Scholar 

  • Huang, A. H. C., Trelease, R. N., and Moore, T. S., 1983, Plant Peroxisomes Academic Press, New York.

    Google Scholar 

  • Imanaka, T., Lazarow, P. B., and Takana, T., 1991, A novel 57 kDa peroxisomal membrane Polypeptide detected by monoclonal antibody (PXMla/207B), Biochim. Biophys. Acta 1062:264–270.

    Article  CAS  PubMed  Google Scholar 

  • Imanaka, T., Small, G. M., and Lazarow, P. B., 1987, Translocation of acyl-CoA oxidase into peroxisomes requires ATP hydrolysis but not a membrane potential, J. Cell Biol. 105:2915–2922.

    Article  CAS  PubMed  Google Scholar 

  • Issemann, I., and Green, S., 1990, Activation of a member of the steroid hormone receptor super-family by peroxisome proliferators, Nature 347:645–650.

    Article  CAS  PubMed  Google Scholar 

  • Jedlitschky, G., Huber, M., Völkl, A., Müller, M., Leier, I., Müller, J., Lehmann, W.-D., Fahimi, H. D., and Keppler, D., 1991, Peroxisomal degradation of leukotrienes by β-oxidation from the (ω)-end, J. Biol. Chem. 266: 24763–24772.

    CAS  PubMed  Google Scholar 

  • Kaldi, K., Diestelkötter, P., Stenbeck, G., Auerbach, S., Jäkle, U., Mägert, H.-J., Wieland, F. T., and Just, W. W., 1993, Membrane topology of the 22 kDa integral membrane protein, FEBS Lett. 315:217–222.

    Article  CAS  PubMed  Google Scholar 

  • Kamijo, K., Kamijo, T., Ueno, I., Osumi, T., and Hashimoto, T., 1992, Nucleotide sequence of the human 70 kDa peroxisomal membrane protein: A member of ATP-binding cassette transporters, Biochim. Biophys. Acta 1129:323–327.

    Article  CAS  PubMed  Google Scholar 

  • Kamijo, K., Taketani, S., Yokota, S., Osumi, T., and Hashimoto, T., 1990, The 70 kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein super-family, J. Biol. Chem. 265:4534–4540.

    CAS  PubMed  Google Scholar 

  • Kase, F., Björkhem, I., and Pedersen, J. I., 1983, Formation of cholic acid from 3α, 7α, 12α-trihydroxy-5β-cholestanoic acid by rat liver peroxisomes, J. Lipid Res. 24:1560–1567.

    CAS  PubMed  Google Scholar 

  • Keller, G. A., Barton, M. C., Shapiro, D. J., and Singer, S. J., 1985, 3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells, Proc. Natl. Acad. Sci. USA 82:770–774.

    Article  CAS  PubMed  Google Scholar 

  • Keller, G.-A., Gould, S., Deluca, M, and Subramani, S., 1987, Firefly luciferase is targeted to peroxisomes in mammalian cells, Proc. Natl. Acad. Sci USA 84:3264–3268.

    Article  CAS  PubMed  Google Scholar 

  • Keller, G.-A., Krisans, S., Gould, S. J., Sommer, J. M., Wang, C. C., Schliebs, W., Kunau, W., Brody, S., and Subramani, S., 1991, Evolutionary conservation of a microbody targeting signal that targets proteins to peroxisomes, glyoxysomes and glycosomes, J. Cell Biol. 114:893–904.

    Article  CAS  PubMed  Google Scholar 

  • Keller, G. A., Pazirandeh, M., and Krisans, S., 1986, 3-Hydroxy-3-methylglutaryl-coenzyme A reductase localization in rat liver peroxisomes and microsomes of control and cholestyramine-treated animals: Quantitative biochemical and immunoelectron microscopic analyses, J. Cell Biol. 103:875–886.

    Article  CAS  PubMed  Google Scholar 

  • Köster, A., Heisig, M., Heinrich, P. C., and Just, W. W., 1986, In vitro synthesis of peroxisomal membrane Polypeptides, Biochem. Biophys. Res. Commun. 137:626–632.

    Article  PubMed  Google Scholar 

  • Krisans, S. K., Mortensen, R. M., Lazarow, P. B., 1980, Acyl-CoA synthetase in rat liver peroxi-somes, J. Biol. Chem. 255:9599–9607.

    CAS  PubMed  Google Scholar 

  • Kunau, W.-H., and Hartig, A., 1992, Peroxisome biogenesis in Saccharomyces cerevisae, Antonie Van Leeuwenhoek 62:63–78.

    Article  CAS  PubMed  Google Scholar 

  • Labarca, P., Wolff, D., Soto, U., Necochea, C., and Leighton, F., 1986, Large cation-selective pores from rat liver peroxisomal membranes incorporated to planar lipid bilayers, J. Membr. Biol. 94:285–291.

    Article  CAS  PubMed  Google Scholar 

  • Lageweg, W., Tager, J. M., and Wanders, R. J. A., 1991, Topography of very long chain fatty acid activating activity in peroxisomes from rat liver, Biochem. J. 275:53–56.

    Google Scholar 

  • Lazarow, P. B., 1984, The peroxisomal membrane, in Membrane Structure and Function (E. E. Bittar, ed.), Vol. 5, pp. 1–31, John Wiley, New York.

    Google Scholar 

  • Lazarow, P. B., and Fujiki, Y., 1985, Biogenesis of peroxisomes, Annu. Rev. Cell Biol. 1:489–530.

    Article  CAS  PubMed  Google Scholar 

  • Lazarow, P. B., and Moser, H. W., 1989, Disorders of peroxisome biogenesis, in The Metabolic Basis of Inherited Disease (C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, eds.), pp. 1479–1509, McGraw-Hill, New York.

    Google Scholar 

  • Lazo, O., Contreras, M., and Singh, I., 1990, Topographical localization of peroxisomal acyl-CoA ligases: Differential localization of palmitoyl-CoA and lignoceroyl-CoA ligases, J. Lipid Res. 31:583–595.

    CAS  PubMed  Google Scholar 

  • Leighton, F., Bergseth, S., Rørtveit, T., Christiansen, E. N., and Bremer, J., 1989, Free acetate production by rat hepatocytes during peroxisomal fatty acid and dicarboxylic acid oxidation, J. Biol. Chem. 264:10347–10350.

    CAS  PubMed  Google Scholar 

  • Leighton, F., Brandan, E., Lazo, O., and Bronfman, M., 1982, Subcellular fractionation studies on the organization of fatty acid oxidation by liver peroxisomes, Ann. NY Acad. Sci. 386:62–80.

    Article  CAS  PubMed  Google Scholar 

  • Leighton, F., Poole, B., Beaufay, H., Baudhuin, P., Coffey, J. W., Fowler, S., and de Duve, C., 1968, The large-scale separation of peroxisomes, mitochondria and lysosomes from the liver of rats injected with Triton WR-1339, J. Cell Biol. 37:482–513.

    Article  CAS  PubMed  Google Scholar 

  • Lemmens, M., Verheyden, K., Van Veldhoven, P., Vereecke, J., Mannaerts, G. P., and Carmeliet, E., 1989, Single-channel analysis of a large conductance channel in peroxisomes from rat liver, Biochim. Biophys. Acta 984:351–359.

    Article  CAS  PubMed  Google Scholar 

  • Liang, Z., and Huang, A. H. C., 1983, Metabolism of glycolate and glyoxylate in intact spinach leaf peroxisomes, Plant Physiol. 73:147–152.

    Article  CAS  PubMed  Google Scholar 

  • Liang, Z., and Huang, A. H. C., 1984, Conversion of glycerate to serine in intact spinach leaf peroxisomes, Arch. Biochem. Biophys. 233:393–401.

    Article  CAS  PubMed  Google Scholar 

  • Lock, E. A., Mitchell, A. M., and Elcombe, C. R., 1989, Biochemical mechanisms of induction of hepatic peroxisome proliferation, Annu. Rev. Pharmacol. Toxicol. 29:145–163.

    Article  CAS  PubMed  Google Scholar 

  • Lüers, G., Beier, K., Hashimoto, T, Fahimi, H. D., and Völkl, A., 1990, Biogenesis of peroxisomes: Sequential biosynthesis of the membrane and matrix proteins in the course of hepatic regeneration, Eur. J. Cell Biol. 52:175–184.

    PubMed  Google Scholar 

  • Luster, D. G., Bowditch, M. L., Eldridge, K. M., and Donaldson, R. P., 1988, Characterization of membrane-bound electron transport enzymes from castor bean glyoxysomes and endoplasmic reticulum. Arch. Biochem. Biophys. 265:50–61.

    Article  CAS  PubMed  Google Scholar 

  • Makita, T., Hakoi, K., and Araki, N., 1990, Cytochemical localization of Mg++-ATPase and Ca++-ATPase on the limiting membrane of rat liver peroxisomes, Arch. Histochem. Cytochem. 23: 601–611.

    Article  CAS  Google Scholar 

  • Malik, Z. A., Tappia, P. S., De Netto, L. A., Burdett, K., Sutton, R., and Connock, M. J., 1991, Properties of ATPase activity associated with peroxisomes of rat and bovine liver, Comp. Biochem. Physiol. 99B:295–300.

    CAS  Google Scholar 

  • Mannaerts, G. P., and Van Veldhoven, P. P., 1987, Permeability of the peroxisomal membrane, in Peroxisomes in Biology and Medicine (H. D. Fahimi and H. Sies, eds.), pp. 169–176, Springer-Verlag, Berlin, Heidelberg.

    Chapter  Google Scholar 

  • Mannaerts, G. P., and Van Veldhoven, P. P., 1990, The peroxisome: Functional properties in health and disease, Biochem. Soc. Trans. 18:87–89.

    CAS  PubMed  Google Scholar 

  • Mannaerts, G. P., and Van Veldhoven, P. P., 1992a, Metabolic role of mammalian peroxisomes, in Peroxisomes: Biology and Importance in Toxicology and Medicine (G. G. Gibson and B. Lake, eds.), pp. 19–62, Taylor and Francis, London.

    Google Scholar 

  • Mannaerts, G. P., and Van Veldhoven, P. P., 1992b, Role of peroxisomes in mammalian metabolism, Cell Biochem. Funct. 10:141–151.

    Article  CAS  PubMed  Google Scholar 

  • Mannaerts, G. P., Van Veldhoven, P., Van Broekhoven, A., Vandebroek, G., and Debeer, L. J., 1982, Evidence that peroxisomal acyl-CoA synthetase is located at the cytoplasmic side of the peroxisomal membrane, Biochem. J. 204:17–23.

    CAS  PubMed  Google Scholar 

  • McCammon, M. T., Dowds, C. A., Orth, K., Moomaw, C. R., Slaughter, C. A., and Goodman, J. M., 1990a, Sorting of peroxisomal membrane protein PMP47 from Candida boidinii into peroxisomal membranes of Saccharomyces cerevisiae, J. Biol. Chem. 265:20098–20105.

    CAS  PubMed  Google Scholar 

  • McCammon, M. T., Veenhuis, M., Trapp, S. B., and Goodman, J. M., 1990b, Association of glyoxylate and beta-oxidation enzymes with peroxisomes of Saccharomyces cerevisiae, J. Bac-teriol. 172:5816–5827.

    CAS  Google Scholar 

  • Miura, S., Mori, M., Takiguchi, M., Tatibana, M., Furuta, S., Miyazawa, S., and Hashimoto, T, 1984, Biosynthesis and intracellular transport of enzymes of peroxisomal β-oxidation, J. Biol. Chem. 259:6397–6402.

    CAS  PubMed  Google Scholar 

  • Miyazawa, S., Hashimoto, T., and Yokota, S., 1985, Identity of long-chain acyl-CoA synthetase of microsomes, mitochondria and peroxisomes, J. Biochem. 98:723–733.

    CAS  PubMed  Google Scholar 

  • Miyamoto, A., Yamamoto, T., Kamiryo, T., and Numa, S., 1981, Purification of long-chain acyl-CoA synthetase of rat liver peroxisomes and its properties, Proc. Jpn. Conf. Biochem. Lipids 23:346–349.

    Google Scholar 

  • Mosser, J., Douar, A.-M., Sarde, C.-O., Kioschis, P., Feil, R., Moser, H., Poustka, A.-M., Mandel, J.-L., and Aubourg, P., 1993, Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters, Nature 361:726–730.

    Article  CAS  PubMed  Google Scholar 

  • Neat, C. E., Thomassen, M. S., and Osmundsen, H., 1980, Induction of peroxisomal β-oxidation in rat liver by high-fat diets, Biochem. J. 186:369–371.

    CAS  PubMed  Google Scholar 

  • Nicolay, K., Veenhuis, M., Douma, A. C., and Harder, W., 1987, A 31P NMR study of the internal pH of yeast peroxisomes, Arch. Microbiol. 147:37–41.

    Article  CAS  PubMed  Google Scholar 

  • Nuttley, W. M., Bodnar, A. G., Mangroo, D., and Rachubinski, R. A., 1990, Isolation and characterization of membranes from oleic acid-induced peroxisomes of Candida tropicalis, J. Cell Sci. 95:463–470.

    CAS  PubMed  Google Scholar 

  • Ohno, S., and Fujii, Y., 1990, Three-dimensional and histochemical studies of peroxisomes in cultured hepatocytes by quick-freezing and deep-etching method, Histochem. J. 22:143–154.

    Article  CAS  PubMed  Google Scholar 

  • Opperdoes, F. R., 1987, Biogenesis of glycosomes (microbodies) in the trypanosomatidae, in Peroxisomes in Biology and Medicine (H. D. Fahimi and H. Sies, eds.), pp. 426–435, Springer-Verlag, Berlin, Heidelberg.

    Chapter  Google Scholar 

  • Opperdoes, F. R., Baudhuin, P., Coppens, L., De Roe, C., Edwards, S. W., Weijers, P. J., and Misset, O., 1984, Purification, morphometric analysis and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei, J. Cell Biol. 98:1178–1184.

    Article  CAS  PubMed  Google Scholar 

  • Osumi, T., and Fujiki, Y., 1990, Topogenesis of peroxisomal proteins, Bioessays 12:217–222.

    Article  CAS  PubMed  Google Scholar 

  • Pais, M. S. S., and Carrapico, F., 1982, Microbodies. A membrane compartment, Ann. NY Acad. Sci. 306:510–513.

    Google Scholar 

  • Patthey, J.-P., and Deshusses, J., 1987, Accessibility of Trypanosoma brucei procyclic glycosomal enzymes to labeling agents of various sizes and charges, FEBS Lett. 210:137–141.

    Article  CAS  PubMed  Google Scholar 

  • Rachubinski, R. A., Fujiki, Y, Mortensen, R. M., and Lazarow, P. B., 1984, Acyl-CoA oxidase and hydratase-dehydrogenase, two enzymes of the peroxisomal β-oxidation system, are synthesized on free polysomes of clofibrate-treated rat liver, J. Cell Biol. 99:2241–2246.

    Article  CAS  PubMed  Google Scholar 

  • Roscher, A. A., Hoefler, S., Hoefler, G., Paschke, E., Paltauf, F., Moser, A., and Moser, H., 1989, Genetic and phenotypic heterogeneity in disorders of peroxisome biogenesis: A complementation study involving cell lines from 19 patients, Pediatr. Res. 26:67–72.

    Article  CAS  PubMed  Google Scholar 

  • Santos, M. J., Imanaka, T., Shio, H., and Lazarow, P. B., 1988, Peroxisomal integral membrane proteins in control and Zellweger fibroblasts, J. Biol. Chem. 263:10502–10509.

    CAS  PubMed  Google Scholar 

  • Schepers, L., Casteels, M., Vamecq, J., Parmentier, G., Van Veldhoven, P. P., and Mannaerts, G. P., 1988, β-Oxidation of the carboxyl side chain of Prostaglandin E2 in rat liver peroxisomes and mitochondria, J. Biol. Chem. 263:2724–2731.

    CAS  PubMed  Google Scholar 

  • Schlossman, D. M., and Bell, R. M., 1977, Microsomal sn-glycerol-3-phosphate and dihydrox-yacetone phosphate acyltransferase activities from liver and other tissues, Arch. Biochem. Biophys. 182:732–742.

    Article  CAS  PubMed  Google Scholar 

  • Schram, A., Strijland, A., Hashimoto, T., Wanders, R. J. A., Schutgens, R. B. H., van den Bosch, H., and Tager, J. M., 1986, Biogenesis and maturation of peroxisomal β-oxidation enzymes in fibroblasts in relation to the Zellweger syndrome and infantile Refsum disease, Proc. Natl. Acad. Sci. USA 83:6156–6158.

    Article  CAS  PubMed  Google Scholar 

  • Shimozawa, N., Tsukamoto, T., Suzuki, Y., Orii, T., Shirayashi, Y., Mori, T., and Fujiki, Y., 1992, A human gene responsible for Zellweger syndrome that affects peroxisome assembly, Science 255:1132–1134.

    Article  CAS  PubMed  Google Scholar 

  • Shindo, Y., and Hashimoto, T., 1978, Acyl-Coenzyme A synthetase and fatty acid oxidation in rat liver peroxisomes, J. Biochem. 84:1177–1181.

    CAS  PubMed  Google Scholar 

  • Singh, H., and Poulos, A., 1988, Distinct long chain and very long chain fatty acyl-CoA synthetases in rat liver peroxisomes and microsomes, Arch. Biochem. Biophys. 259:382–390.

    Article  Google Scholar 

  • Singh, H., Usher, S., and Poulos, A., 1989, Dihydroxyacetone phosphate acyltransferase and alkyldihydroxyacetone phosphate synthase activities in rat liver subcellular fractions and human skin fibroblasts, Arch. Biochem. Biophys. 268:676–686.

    Article  CAS  PubMed  Google Scholar 

  • Singh, I., Lazo, O., Contreras, M., Stanley, W., and Hashimoto, T., 1991, Rhizomelic chondrodysplasia punctata: Biochemical studies of peroxisomes isolated from cultured skin fibroblasts, Arch. Biochem. Biophys. 286:277–283.

    Article  CAS  PubMed  Google Scholar 

  • Singh, I., Moser, A. E., Goldfischer, S., and Moser, H. W., 1984, Lignoceric acid is oxidized in the peroxisome: Implications for the Zellweger cerebro-hepato-renal syndrome and adrenoleuko-dystrophy, Proc. Natl. Acad. Sci. USA 81:4203–4207.

    Article  CAS  PubMed  Google Scholar 

  • Skorin, C., Soto, U., Necochea, C., and Leighton, F., 1986, Protein phosphorylation in peroxisomes, Biochem. Biophys. Res. Commun. 140:188–194.

    Article  CAS  PubMed  Google Scholar 

  • Small, G. M., Santos, M. J., Imanaka, T., Poulos, A., Danks, D. M., Moser, H. W., and Lazarow, P. B., 1988, Peroxisomal integral membrane proteins in livers of patients with Zellweger syndrome, infantile Refsum’s disease and X-linked adrenoleukodystropy, J. Inherit. Metab. Dis. 11:358–371.

    Article  CAS  PubMed  Google Scholar 

  • Subramani, S., 1992, Targeting of proteins into the peroxisomal matrix, J. Memb. Biol. 125:99–106.

    Article  CAS  Google Scholar 

  • Suiter, G. J., Looyenga, L., Veenhuis, M., and Harder, W., 1990, Occurrence of peroxisomal membrane proteins in methylotrophic yeasts grown under different conditions, Yeast 6:35–43.

    Article  Google Scholar 

  • Suiter, G. J., Verheyden, K., Mannaerts, G. P., Harder, W., and Veenhuis, M., 1993, The in vitro permeability of yeast peroxisomal membranes is caused by a 31 kDa integral membrane protein, Yeast, 9:733–742.

    Article  Google Scholar 

  • Suzuki, H., Kawarabayasi, Y., Kondo, J., Abe, T., Nishikawa, K., Kimura, S., Hashimoto, T., and Yamamoto, T., 1990, Structure and regulation of rat long-chain acyl-CoA synthetase, J. Biol. Chem. 265:8681–8685.

    CAS  PubMed  Google Scholar 

  • Suzuki, Y., Orii, T., Takiguchi, M., Mori, M., Hijikata, M., and Hashimoto, T., 1987, Biosynthesis of membrane Polypeptides of rat liver peroxisomes, J. Biochem. 101:491–496.

    CAS  PubMed  Google Scholar 

  • Suzuki, Y., Shimozawa, N., Orii, T., and Hashimoto, T., 1989, Major peroxisomal membrane Polypeptides are synthesized in cultured skin fibroblasts from patients with Zellweger syndrome, Pediatr. Res. 26:150–153.

    Article  CAS  PubMed  Google Scholar 

  • Swinkels, B. W., Gould, S. J., Bodnar, A. G., Rachubinski, R. A., and Subramani, S., 1991, A novel cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase, EMBO J. 10:3255–3262.

    CAS  PubMed  Google Scholar 

  • Tanaka, A., Osumi, M., and Fukui, S., 1982, Peroxisomes of alkane-grown yeast: Fundamental and practical aspects, Ann. NY Acad. Sci. 386:183–198.

    Article  CAS  PubMed  Google Scholar 

  • Thompson, S. L., Burrows, R., Laub, R. J., and Krisans, S. K., 1987, Cholesterol synthesis in rat liver peroxisomes, J. Biol. Chem. 262:17420–17425.

    CAS  PubMed  Google Scholar 

  • Tolbert, N. E., 1981, Metabolic pathways in peroxisomes and glyoxysomes, Annu. Rev. Biochem. 50:133–157.

    Article  CAS  PubMed  Google Scholar 

  • Tsukamoto, T., Miura, S., and Fujiki, Y., 1991, Restoration by a 35 K membrane protein of peroxisome assembly in a peroxisome-deficient mammalian cell mutant, Nature 350:77–81.

    Article  CAS  PubMed  Google Scholar 

  • Vanhove, G., Van Veldhoven, P. P., Vanhoutte, F., Parmentier, G., Eyssen, H. J., and Mannaerts, G. P., 1991, Mitochondrial and peroxisomal β-oxidation of the branched chain fatty acid 2-methylpalmitate in rat liver, J. Biol. Chem. 266:24670–24675.

    CAS  PubMed  Google Scholar 

  • Van Veldhoven, P., Debeer, L. J., and Mannaerts, G. P., 1983, Water-and solute-accessible spaces of purified peroxisomes: Evidence that peroxisomes are permeable to NAD+, Biochem. J. 210:685–693.

    PubMed  Google Scholar 

  • Van Veldhoven, P. P., 1986, The permeability of the Peroxisomal Membrane, Ph.D. Thesis, Ka-tholieke Universiteit Leuven, Belgium.

    Google Scholar 

  • Van Veldhoven, P. P., Just, W. W., and Mannaerts, G. P., 1987, Permeability of the peroxisomal membrane to cofactors of β-oxidation: Evidence for the presence of a pore-forming protein, J. Biol. Chem. 262:4310–4318.

    PubMed  Google Scholar 

  • Van Veldhoven, P. P., and Mannaerts, G. P., 1986, Coenzyme A in purified peroxisomes is not freely soluble in the matrix but firmly bound to a matrix protein. Biochem. Biophys. Res. Commun. 139:1195–1201.

    Article  PubMed  Google Scholar 

  • Veenhuis, M., and Goodman, J. M., 1990, Peroxisomal assembly: Membrane proliferation precedes the induction of the abundant matrix proteins in the methylotrophic yeast Candida boidinii, J. Cell Sci. 96:583–590.

    CAS  PubMed  Google Scholar 

  • Veenhuis, M., and Harder, W., 1987, Metabolic significance and biogenesis of microbodies in yeasts, in Peroxisomes in Biology and Medicine (H. D. Fahimi and H. Sies, eds.), pp. 436–458, Springer-Verlag, Berlin, Heidelberg.

    Chapter  Google Scholar 

  • Veenhuis, M., Keizer, I., and Harder, W., 1979, Characterization of peroxisomes in glucose-grown Hansenula polymorpha and their development after the transfer of cells into methanol-containing media, Arch. Microbiol. 120:167–175.

    Article  CAS  Google Scholar 

  • Verheyden, K., Fransen, M., Van Veldhoven, P. P., and Mannaerts, G. P., 1992, Presence of small GTP-binding proteins in the peroxisomal membrane, Biochim. Biophys. Acta 1109:48–54.

    Article  CAS  PubMed  Google Scholar 

  • Verleur, N., and Wanders, R. J. A., 1993, Permeability properties of peroxisomes in rat liver, Biol. Cell 77:109.

    Google Scholar 

  • Völkl, A., and Fahimi, H. D., 1985, Isolation and characterization of peroxisomes from the liver of normal untreated rats, Eur. J. Biochem. 149:257–265.

    Article  PubMed  Google Scholar 

  • Walton, P. A., Gould, S. J., Feramisco, J. R., and Subramani, S., 1992, Transport of microinjected proteins into peroxisomes of mammalian cells: Inability of Zellweger ceil lines to import proteins with the SKL tripeptide peroxisomal targeting signal, Mol. Cell. Biol. 12:531–541.

    CAS  PubMed  Google Scholar 

  • Wanders, R. J. A., van Roermund, C. W. T., Schutgens, R. B. H., Barth, P. G., Heymans, H. S. A., van den Bosch, H., and Tager, J. M., 1990, The inborn errors of peroxisomal β-oxidation: A review, J. Inherit. Metabol. Dis. 13:4–36.

    Article  CAS  Google Scholar 

  • Waterham, H. R., Keizer-Gunnink, I., Goodman, J. M., Harder, W., and Veenhuis, M., 1990, Immunocytochemical evidence for the acidic nature of peroxisomes in methylotrophic yeasts, FEES Lett. 262:17–19.

    Article  CAS  Google Scholar 

  • Webber, K. O., and Hajra, A. K., 1993, Purification of dihydroxyacetone phosphate acyltransferase from guinea pig peroxisomes, Arch. Biochem. Biophys. 300:88–97.

    Article  CAS  PubMed  Google Scholar 

  • Whitney, A. B., and Bellion, E., 1991, ATPase activities in peroxisome-proliferating yeast, Bio-chim. Biophys. Acta 1058:345–355.

    Article  CAS  Google Scholar 

  • Wilson, G. N., and King, T. E., 1991, Structure and variability of mammalian peroxisomal membrane proteins, Biochem. Med. Metab. Biol. 46:235–245.

    Article  CAS  PubMed  Google Scholar 

  • Wolvetang, E. J., Tager, J. M., and Wanders, R. J. A., 1990a, Latency of the peroxisomal enzyme acyl-CoA: Dihydroxyacetone phosphate acyltransferase in digitonin-permeabilized fibroblasts: The effect of ATP and ATPase inhibitors, Biochem. Biophys. Res. Commun. 170:1135–1143.

    Article  CAS  PubMed  Google Scholar 

  • Wolvetang, E. J., Tager, J. M., and Wanders, R. J. A., 1991, Factors influencing the latency of the peroxisomal enzyme dihydroxyacetone-phosphate acyltransferase in permeabilized human skin fibroblasts, Biochim. Biophys. Acta 1095:122–126.

    Article  CAS  PubMed  Google Scholar 

  • Wolvetang, E. J., Wanders, R. J. A., Schutgens, R. B. H., Berden, J. A., and Tager, J. M., 1990b, Properties of the ATPase activity associated with peroxisome-enriched fractions from rat liver: Comparison with mitochondrial F1F0-ATPase, Biochim. Biophys. Acta 1035:6–11.

    Article  CAS  PubMed  Google Scholar 

  • Yamamoto, K., and Fahimi, H. D., 1987, Three-dimensional reconstruction of a peroxisomal reticu-lum in regenerating rat liver: Evidence of interconnections between heterogeneous segments, J. Cell Biol. 105:713–722.

    Article  CAS  PubMed  Google Scholar 

  • Yu, C., and Huang, A. H. C., 1986, Conversion of serine to glycerate in intact spinach leaf peroxisomes: Role of malate dehydrogenase, Arch. Biochem. Biophys. 245:125–133.

    Article  CAS  PubMed  Google Scholar 

  • Zwacka, R., Karasawa, M., and Weiher, H., 1993, The transgenic mouse strain Mpv17 as a model for peroxisomal disease, Biol. Cell 77:116.

    Google Scholar 

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Van Veldhoven, P.P., Mannaerts, G.P. (1994). Assembly of the Peroxisomal Membrane. In: Maddy, A.H., Harris, J.R. (eds) Membrane Biogenesis. Subcellular Biochemistry, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2401-4_8

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