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Cytomegalovirus Infection in Marrow Transplantation

  • Chapter
Technical and Biological Components of Marrow Transplantation

Part of the book series: Cancer Treatment and Research ((CTAR,volume 76))

Abstract

Historically, cytomegalovirus (CMV) disease has been the leading infectious cause of death after allogeneic marrow transplantation [1], Considerable progress has been made in understanding the immunology, development of diagnostic techniques, and prevention of CMV infection and disease after marrow transplantation. Recent advances made in prevention of CMV disease include the availability of antiviral agents as well as prevention of transfusion-acquired infection. This has led to a significant reduction of CMV disease after allogeneic marrow transplantation in both seropositive and seronegative patients. By contrast, continuing challenges include the treatment of CMV disease, particularly CMV pneumonia, and the prevention of CMV disease in seropositive autograft recipients in whom the risk of CMV infection is lower than in allograft recipients but the outcome is as severe.

This chapter is dedicated to the memory of Joel D. Meyers, M.D., a pioneer, leader, and our colleague in the field of cytomegalovirus infections after marrow transplantation.

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Authors
  1. Michael Boeckh
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  2. Raleigh Bowden
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Editors and Affiliations

  1. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    C. Dean Buckner  & R. A. Clift  & 

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© 1995 Springer Science+Business Media New York

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Boeckh, M., Bowden, R. (1995). Cytomegalovirus Infection in Marrow Transplantation. In: Buckner, C.D., Clift, R.A. (eds) Technical and Biological Components of Marrow Transplantation. Cancer Treatment and Research, vol 76. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2013-9_5

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  • DOI: https://doi.org/10.1007/978-1-4615-2013-9_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5832-9

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