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Cellular Adoptive Immunotherapy after Bone Marrow Transplantation

  • Chapter
Technical and Biological Components of Marrow Transplantation

Part of the book series: Cancer Treatment and Research ((CTAR,volume 76))

Abstract

Cellular adoptive immunotherapy has been broadly used to describe the transfer of effector cells of the immune system to treat malignant or infectious diseases. This approach to restoring or augmenting inadequate host immune responses is based upon several premises. Firstly, it is assumed that it will be possible to isolate effector cells from the host or a suitable donor with reactivity for the relevant tumor or pathogen. Secondly, the effector cells must be capable of being expanded in vitro to numbers sufficient to mediate therapeutic effects following adoptive transfer. Finally, it is anticipated that reinfusion of the effector cells could be accomplished without toxicity to the host and that the transferred cells would persist in vivo for a sufficient duration to eradicate the tumor or pathogen. The validity of these assumptions has been firmly established by detailed experimentation in animal models over the past two decades, but several impediments, in part based on an inadequate understanding of the biology of the effector cells potentially useful in adoptive immunotherapy, have hindered clinical applications and impacted on the success of the initial attempts at adoptive therapy for human diseases.

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  1. Stanley R. Riddell
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Riddell, S.R., Greenberg, P.D. (1995). Cellular Adoptive Immunotherapy after Bone Marrow Transplantation. In: Buckner, C.D., Clift, R.A. (eds) Technical and Biological Components of Marrow Transplantation. Cancer Treatment and Research, vol 76. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2013-9_16

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