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Graft Versus Leukemia in Humans

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Technical and Biological Components of Marrow Transplantation

Part of the book series: Cancer Treatment and Research ((CTAR,volume 76))

Abstract

The notion of an antileukemia effect of allogeneic bone marrow transplants distinct from the high-dose pretransplant drugs and radiation given derives from experiments in mice with leukemia [1]. Recipients of allogeneic grafts have fewer relapses than recipients of syngeneic grafts given the same pretransplant chemotherapy with or without radiation. This antileukemia effect is mediated by allogeneic immune cells and is termed graft versus leukemia (GVL) [2]. In most animal models, GVL is associated with graft-versus-host disease (GVHD); exceptions are gnotobiotic mice and mice given total lymphoid radiation, in whom GVL may occur without GVHD [3].

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  1. Anna Butturini
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  2. Robert Peter Gale
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Editors and Affiliations

  1. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    C. Dean Buckner  & R. A. Clift  & 

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Butturini, A., Peter Gale, R. (1995). Graft Versus Leukemia in Humans. In: Buckner, C.D., Clift, R.A. (eds) Technical and Biological Components of Marrow Transplantation. Cancer Treatment and Research, vol 76. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2013-9_14

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  • DOI: https://doi.org/10.1007/978-1-4615-2013-9_14

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