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Coronary Adenosine Receptors: Subtypes, Localization, and Function

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Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology

Abstract

Despite the historic observations of Drury and Szent Gyorgyi in 1929 [1] that adenosine causes coronary vasodilation, hypotension, and bradycardia, it was not until 30 years later that Berne [2] proposed the adenosine hypothesis for the metabolic regulation of coronary blood flow. A large body of literature has been accumulated on the cardiovascular actions of adenosine since that time.

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References

  1. Drury AN, Szent-Gyorgyi A (1929) The physiological activity of adenine compounds with special reference to their action upon the mammalian heart. J Physiol 68:213–237.

    PubMed  CAS  Google Scholar 

  2. Berne RM (1963) Cardiac nucleotides in hypoxia: A possible role in regulation of coronary blood flow. Am J Physiol 204:317–322.

    PubMed  CAS  Google Scholar 

  3. Olsson RA, Davis CJ, Khouri EM, Patterson RE (1976) Evidence for an adenosine receptor on the surface of dog coronary myocytes. Circ Res 39:93–98.

    Article  PubMed  CAS  Google Scholar 

  4. Cushing DJ, Brown GL, Sabouni MH, Mustafa SJ (1991) Adenosine-receptor-mediated coronary artery relaxation and cyclic nucleotide production. Am J Physiol 261:H343–H348.

    PubMed  CAS  Google Scholar 

  5. Sabouni MH, Hussain T, Cushing DJ, Mustafa SJ (1991) G-proteins subserve relaxation mediated by adenosine receptors in human coronary artery. J Cardiovasc Pharmacol 18:696–702.

    Article  PubMed  CAS  Google Scholar 

  6. Hussain T, Mustafa SJ (1992) Effects of adenosine analogs on cholera toxin induced ADP-ribosylation of G-proteins in coronary artery. Am J Physiol 262:H875–H879.

    PubMed  CAS  Google Scholar 

  7. Ramagopal MV, Chitwood R, Mustafa SJ (1988) Evidence for an A2 adenosine receptor in human coronary arteries. Eur J Pharmacol 151: 483–486.

    Article  PubMed  CAS  Google Scholar 

  8. Sabouni MH, Mustafa SJ (1989) Effects of adenosine analogs on phasic contractions in human coronary artery. Eur J Pharmacol 168:271–276.

    Article  PubMed  CAS  Google Scholar 

  9. Sabouni MH, Ramagopal MV, Mustafa SJ (1990) Relaxation by adenosine and its analogs in potassium contracted human coronary arteries. Naunyn Schmiedbergs Arch Pharmacol 341: 388–390.

    Article  CAS  Google Scholar 

  10. Makujina S, Sabouni MH, Bhatia S, Douglas FL, Mustafa SJ (1992) Vasodilatory effects of adenosine A2 receptor agonists CGS 21680 and CGS 22492 in human vasculature. Eur J Pharm 221:243–247.

    Article  CAS  Google Scholar 

  11. Mustafa SJ (1980) Cellular and molecular mechanism(s) of coronary flow regulation by adenosine. Mol Cell Biochem 31:67–87.

    Article  PubMed  CAS  Google Scholar 

  12. Cushing DJ, Mustafa SJ (1991) Historical perspective-Adenosine. In Phillis JW (ed.), Adenosine and Adenine Nucleotides as Regulators of Cellular Function. Boca Raton, FL: CRC Press, pp. 3–13.

    Google Scholar 

  13. Linden J, Prater MR, Tucker A, Thompson RD, Olsson RA (1992) 125I-APE, a new and improved radioligand that binds selectively to native and recombinant adenosine A2a receptors (abstr). Int J Purine Pyrimidine Res 3:86.

    Google Scholar 

  14. Cornfield LJ, Hu S, Hurt SD, Sills MA (1992) [3H]2-phenylaminoadenosine ([3H]CV- 1808) labels a novel adenosine receptor in rat brain. J Pharmacol Exp Ther 263:552–561.

    PubMed  CAS  Google Scholar 

  15. Makujina SR, Olanrewaju HA, Mustafa SJ (1994) Evidence against the involvement of ATP-sensitive K+ channels in adenosine A2 receptor-mediated vasorelaxation. Am J Physiol 267:H716–H724.

    PubMed  CAS  Google Scholar 

  16. Luthin DR, Linden J (1994) Temperature-dependent binding of [3H]CV 1808: Mimicry of “A4” binding in COS cells expressing only recombinant A2a adenosine receptors (abstr). Drug Dev Res 31:292.

    Google Scholar 

  17. Hussain T, Mustafa SJ (1993) An in vitro pharmacological model in coronary smooth muscle. J Pharmacol Toxicol Methods 30: 111–115.

    Article  PubMed  CAS  Google Scholar 

  18. Hussain T, Mustafa SJ (1993) Regulation of adenosine receptor system in coronary artery: Functional studies and cAMP. Am J Physiol 264 (Heart Circ Physiol 33):H441–H447.

    PubMed  CAS  Google Scholar 

  19. Hussain T, Mustafa SJ (1994) Regulation of G proteins coupled to adenosine receptors in coronary artery. Am J Physiol 266 (Heart Circ Physiol 35):H1273–H1279.

    PubMed  CAS  Google Scholar 

  20. Abebe W, Makujina S, Mustafa SJ (1994) Adenosine receptor-mediated relaxation of porcine coronary artery in presence and absence of endothelium. Am J Physiol 266:H2018—H2025.

    PubMed  Google Scholar 

  21. Vials A, Burnstock G (1993) A2-purinoceptormediated relaxation in the guinea pig coronary vascular: A role for nitric oxide. Br J Pharmacol 109:424–429.

    Article  PubMed  CAS  Google Scholar 

  22. Newman WH, Becker BF, Heirer H, Nees S, Gerlch E (1988) Endothelium-mediated coronary dilatation by adenosine does not depend on endothelial adenylate cyclase activation: Studies in isolated guinea pig hearts. Pflügers Arch 413:1–7.

    Article  PubMed  CAS  Google Scholar 

  23. Sabouni MH, Ramagopal MV, Mustafa SJ (1989) Roles of calcium and the endothelium in the relaxation produced by 5’-N-ethylcarboxamido-adenosine (NECA). Eur J Pharmacol 166:311–314.

    Article  PubMed  CAS  Google Scholar 

  24. Olanrewaju HA, Hargittai PT, Lieberman EM, Mustafa SJ (1994) Endothelium-dependent and independent hyperpolarization by adenosine and its analogs in porcine coronary artery. J Cardiovasc Pharmacol, in press.

    Google Scholar 

  25. Feleton M, Vanhoutte PM (1988) Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br J Pharmacol 93:515–524.

    Article  Google Scholar 

  26. Mustafa SJ, Askar A (1985) Evidence suggesting a Ra-type adenosine receptor in bovine coronary arteries. J Pharmacol Exp Ther 232: 49–56.

    PubMed  CAS  Google Scholar 

  27. Merkel LA, Lappe RW, Rivera LM, Cox LM, Perrone MH (1992) Demonstration of vasorelaxant activity with an A1-selective adenosine agonist in porcine coronary artery: Involvement of potassium channels. J Pharmacol Exp Ther 266:437–443.

    Google Scholar 

  28. Merkel LA, Rivera LM, Colussi DJ, Perrone MH (1991) Protein kinase C and vascular smooth muscle contractility: Effects of inhibitors and down-regulation. J Pharmacol Exp Ther 257: 134–140.

    PubMed  CAS  Google Scholar 

  29. Marala RB, Ways K, Mustafa SJ (1993) 2Chloroadenosine prevents phorbol ester-induced depletion of protein kinase C in porcine coronary artery. Am J Physiol 264 (Heart and Circ Physiol 33):H1465–1471.

    PubMed  CAS  Google Scholar 

  30. Young S, Parker PJ, Ullrich A, Stabel S (1987) Down-regulation of protein kinase C is due to an increased rate of degradation. Biochem J 244: 775–779.

    PubMed  CAS  Google Scholar 

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Authors
  1. S. Jamal Mustafa
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  2. Ravi Marala
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  3. Worku Abebe
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  4. Neil Jeansonne
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  5. Hammed Olanrewaju
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  6. Tahir Hussain
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Editor information

Editors and Affiliations

  1. University of Florida, USA

    Luiz Belardinelli

  2. Hahnemann University, USA

    Amir Pelleg

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© 1995 Springer Science+Business Media New York

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Mustafa, S.J., Marala, R., Abebe, W., Jeansonne, N., Olanrewaju, H., Hussain, T. (1995). Coronary Adenosine Receptors: Subtypes, Localization, and Function. In: Belardinelli, L., Pelleg, A. (eds) Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2011-5_27

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  • DOI: https://doi.org/10.1007/978-1-4615-2011-5_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5831-2

  • Online ISBN: 978-1-4615-2011-5

  • eBook Packages: Springer Book Archive

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