Abstract
Granulocyte-macrophage colony stimulating factor (GM-CSF) is an hematopoietic growth factor that has been named after its ability to induce the proliferation and maturation of precursor cells into colonies of granulocytes and macrophages1,2. However, GM-CSF is not simply a proliferative stimulus, but also is a polyfiinctional regulator that affects the growth and function of granulocytes, macrophages, eosinophils, basophils, keratinocytes, dendritic, endothelial cells and also mature, cloned T-lymphocytes3. It increases DNA synthesis in transformed cells, enhances neutrophil chemotaxis, and the phagocytic, cytotoxic and microbicidal action of neutrophils and macrophages3.
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Taglietti, M. (1995). Vaccine Adjuvancy: A New Potential Area of Development for GM-CSF. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_127
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DOI: https://doi.org/10.1007/978-1-4615-1971-3_127
Publisher Name: Springer, Boston, MA
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