Abstract
Activation of human T lymphocytes by mitogens or cytokines is a key event in the control of surface receptors central to the metabolism of these cells. Receptors for a wide range of compounds such as IL-2 (1) and serotonin (2) can be induced on human T lymphocytes by phytohemagglutin (PHA) and IL-2, alone or in combination. Similarly, PHA plus IL-1 induces an opiate receptor on murine thymocytes (3). We report below that treatment of human T lymphocytes by PHA followed by incubation with IL-2 leads to the appearance of a saturable morphine binding site. Morphine binding to this site is displaceable by both naloxone and B-endorphin, but not by such classic mu ligands as DAGO or morphiceptin.
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© 1995 Springer Science+Business Media New York
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Madden, J.J., Ketelsen, D., Whaley, W.L., Donahoe, R.M., Oleson, D. (1995). Mitogenic Activation of Human T Lymphocytes Induces a High Affinity Morphine Binding Site. In: Sharp, B.M., Eisenstein, T.K., Madden, J.J., Friedman, H. (eds) The Brain Immune Axis and Substance Abuse. Advances in Experimental Medicine and Biology, vol 373. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1951-5_6
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DOI: https://doi.org/10.1007/978-1-4615-1951-5_6
Publisher Name: Springer, Boston, MA
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