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The Leucocyte Protein L1 (Calprotectin): A Putative Nonspecific Defence Factor at Epithelial Surfaces

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Advances in Mucosal Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 371))

Abstract

The leucocyte antigen L1 is a calcium-binding, highly immunogenic molecule which predominantly consists of different polypeptide chains adding up to an Mr≈36 K noncovalently stabilized complex.1 Peptides I and II are virtually identical (L1H chain) whereas the smaller peptide III is structurally and antigenically in the main different (L1L chain).2 L1 was discovered more than 10 years ago as a major cytosol protein fraction (50–60%) of neutrophilic granulocytes.3 In addition to being expressed by most circulating (and emigrated) neutrophils and monocytes4, it is also found in a subset of reactive tissue macrophages and many tissue eosinophils.5 Its abundant occurrence in vivo as an Mr≈36 K peptide complex both in neutrophils and monocytes has recently been confirmed6,7.

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Author information

Authors and Affiliations

  1. Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, Norway

    Per Brandtzaeg, Tor-Øivind Gabrielsen, Inge Dale & Fredrik Müller

  2. Department of Dermatology, Norway

    Tor-Øivind Gabrielsen

  3. Institute of Bacteriology, The National Hospital, Rikshospitalet, Norway

    Fredrik Müller

  4. Departments of Microbiology and Immunology, Ullevål Hospital, University of Oslo, Oslo, Norway

    Martin Steinbakk & Magne K. Fagerhol

Authors
  1. Per Brandtzaeg
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  2. Tor-Øivind Gabrielsen
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  3. Inge Dale
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  4. Fredrik Müller
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  5. Martin Steinbakk
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  6. Magne K. Fagerhol
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Editor information

Editors and Affiliations

  1. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Jiri Mestecky , Michael W. Russell , Susan Jackson  & Suzanne M. Michalek , ,  & 

  2. Academy of Sciences of the Czech Republic, Prague, Czech Republic

    Helena Tlaskalová-Hogenová  & Jaroslav Šterzl  & 

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© 1995 Springer Science+Business Media New York

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Brandtzaeg, P., Gabrielsen, TØ., Dale, I., Müller, F., Steinbakk, M., Fagerhol, M.K. (1995). The Leucocyte Protein L1 (Calprotectin): A Putative Nonspecific Defence Factor at Epithelial Surfaces. In: Mestecky, J., Russell, M.W., Jackson, S., Michalek, S.M., Tlaskalová-Hogenová, H., Šterzl, J. (eds) Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 371. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1941-6_41

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  • DOI: https://doi.org/10.1007/978-1-4615-1941-6_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5796-4

  • Online ISBN: 978-1-4615-1941-6

  • eBook Packages: Springer Book Archive

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