Abstract
Prevalent current opinion depicts the basic chemoreceptive unit in the carotid body as a glomus or Type I cell being a storehouse of several neurotransmitters; apposed to it is a neuron, properly called a dendrite, whose cell body is in the petrosal ganglion and whose axon terminates in nucleus tractus solitarius. Prevalent current opinion describes hypoxic chemotransduction in the following steps: (a) Hypoxia by some mechanism, perhaps involving a change in the configuration of a membrane protein, depolarizes the glomus cell, perhaps by altering the conductance of an ion channel in the membrane; (b) Extracellular calcium enters the glomus cell; (c) One or more excitatory neurotransmitters is released into the synaptic cleft between the glomus cell and the apposed neuron; (d) The neurotransmitter binds to a postsynaptic receptor; (e) An action potential is initiated in the neuron. OUR HYPOTHESIS: ACETYLCHOLINE IS AN ESSENTIAL EXCITATORY NEUROTRANSMITTER IN THE PROCESS OF HYPDXIC CHEMOTRANSD UCTION.
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Fitzgerald, R.S., Shirahata, M., Ide, T. (1995). Cholinergic Dimensions to Carotid Body Chemotransduction. In: Semple, S.J.G., Adams, L., Whipp, B.J. (eds) Modeling and Control of Ventilation. Advances in Experimental Medicine and Biology, vol 393. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1933-1_57
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DOI: https://doi.org/10.1007/978-1-4615-1933-1_57
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