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New Retinal Degenerations in the Mouse

  • Chapter
Degenerative Diseases of the Retina

Abstract

For many years we followed with great interest the comparative advances of genetics in the mouse[l] and in human. [2] Relative frequencies of dominant and recessive traits were similar, mapping of genes proceeded at similar rates, and comparative mapping produced surprises through the discovery of the large number and size of mouse and human homologous chromosomal segments retained since the separation of the species 65 million years ago. What was different between mouse and human was the relative frequency of genetic eye disorders, that is, they were relatively frequent in human, and rare in mouse. Recognizing this was because of bias in ascertainment, because mice do not refer themselves for visual diagnosis and treatment, we began a systematic program to find and characterize mouse eye disorders. The Jackson Laboratory, having the largest collection of mouse mutant stocks and genetically diverse inbred strains was an ideal place to look for genetically determined eye variations and disorders. We have not been disappointed. Through ophthalmoscopy, electroretinography and histology, we have discovered disorders affecting all aspects of the eye including the lid, cornea, iris, lens, and retina, resulting in cornea disorders, cataracts, retinal degenerations and glaucoma. Additional studies have shown predisposition to certain eye problems in aged mice of specific stocks or strains.

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Author information

Authors and Affiliations

  1. The Jackson Laboratory, Bar Harbor, Maine, USA

    Thomas H. Roderick, Bo Chang & Norman L. Hawes

  2. The Jules Stein Eye Institute, Los Angeles, California, USA

    John R. Heckenlively

Authors
  1. Thomas H. Roderick
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  2. Bo Chang
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  3. Norman L. Hawes
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  4. John R. Heckenlively
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Editor information

Editors and Affiliations

  1. University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  2. University of California, San Francisco, San Francisco, California, USA

    Matthew M. LaVail

  3. The Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Joe G. Hollyfield

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© 1995 Springer Science+Business Media New York

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Roderick, T.H., Chang, B., Hawes, N.L., Heckenlively, J.R. (1995). New Retinal Degenerations in the Mouse. In: Anderson, R.E., LaVail, M.M., Hollyfield, J.G. (eds) Degenerative Diseases of the Retina. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1897-6_9

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  • DOI: https://doi.org/10.1007/978-1-4615-1897-6_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5774-2

  • Online ISBN: 978-1-4615-1897-6

  • eBook Packages: Springer Book Archive

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