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Haptoglobin

A Potential Reporter Molecule for Glycosylation Changes in Disease

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Glycoimmunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 376))

Abstract

The acute-phase protein, haptoglobin, is elevated in many diseases; however, its glycosylation also changes, and the type of change observed can vary with disease. Increased fucosylation is a common finding, and the fucose-specific lectin, lotus tetragonolobus, can be used to differentiate different diseases (eg inflammatory conditions, liver diseases), and to monitor disease activity in cancer. Changes in N-acetyl neuraminic acid and N-acetylglu-cosamine suggest that particular carbohydrate structures predominate in certain diseases. Because haptoglobin glycosylation provides a record of previous intracellular events, it will help to improve our understanding of pathological processes and provide potential clinical markers for the future.

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Authors and Affiliations

  1. Department of Clinical Biochemistry, The Medical School, Newcastle upon Tyne, NE2 4HH, UK

    G. A. Turner

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  1. G. A. Turner
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Editor information

Editors and Affiliations

  1. St. George’s Hospital Medical School, University of London, London, England

    Azita Alavi  & John S. Axford  & 

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© 1995 Springer Science+Business Media New York

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Turner, G.A. (1995). Haptoglobin. In: Alavi, A., Axford, J.S. (eds) Glycoimmunology. Advances in Experimental Medicine and Biology, vol 376. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1885-3_25

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  • DOI: https://doi.org/10.1007/978-1-4615-1885-3_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5768-1

  • Online ISBN: 978-1-4615-1885-3

  • eBook Packages: Springer Book Archive

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