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Shock and Multiple Organ Failure

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Free Radicals in Diagnostic Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 366))

Abstract

Multiple organ dysfunction syndrome (MODS), previously known as multiple organ failure, has emerged as the leading cause of mortality in surgical critical care. It is a syndrome of sequential and progressive organ dysfunction, associated with a sustained, massive inflammatory response that is often preceded by insults such as sepsis, hemorrhagic shock, inflammatory states such as pancreatitis, and tissue injury. Classically, organ involvement occurs in a predictable sequence, initially involving the lung, then the liver, then the gut, and other organs. With four organ system involvement, mortality approaches 100%. Once the process is initiated, MODS often progresses despite eradication of the inciting cause.

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Authors and Affiliations

  1. Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA

    Patricia A. Abello, Timothy G. Buchman & Gregory B. Bulkley

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  1. Patricia A. Abello
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  2. Timothy G. Buchman
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  1. State University of New York at Buffalo, Buffalo, New York, USA

    Donald Armstrong

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Abello, P.A., Buchman, T.G., Bulkley, G.B. (1994). Shock and Multiple Organ Failure. In: Armstrong, D. (eds) Free Radicals in Diagnostic Medicine. Advances in Experimental Medicine and Biology, vol 366. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1833-4_18

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  • DOI: https://doi.org/10.1007/978-1-4615-1833-4_18

  • Publisher Name: Springer, Boston, MA

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