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The MAP System

A Flexible and Unambiguous Vaccine Design of Branched Peptides

  • Chapter
Vaccine Design

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 6))

Abstract

Conventional vaccines consisting of either killed or attenuated infectious agents are limited in their potential by several factors. These include hazards associated with the production, storage that requires a cold chain, presence of contaminating materials, risk of infection in immunocompromised people, and unwanted side effects in the case of incomplete attenuation of the pathogen.

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References

  • Adorini, L., Harvey, M. A., Miller, A., and Sercarz, E. E., 1979, Fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg-white lysozyme in a genetically non-responder mouse strain, J. Exp. Med. 150:293–306.

    Article  PubMed  CAS  Google Scholar 

  • Berzofsky, J. A., Pendleton, C. D., Clerici, M., Ahlers, J., Lucey, D. R., Putney, S. D., and Shearer, G. M., 1991, Construction of peptides encompassing multideterminant clusters of HIV envelope to induce in vitro T-cell responses in mice and humans of multiple MHC types, J. Clin. Invest. 88:876–884.

    Article  PubMed  CAS  Google Scholar 

  • Briand, J.-P., Muller, S., and Van Regenmortel, M. H. V., 1985, Synthetic peptides as antigens: Pitfalls of conjugation methods, J. Immunol. Methods 78:59–69.

    Article  PubMed  CAS  Google Scholar 

  • Briand, J.-P., Andre, C., Tuaillon, N., Herve, L., Neimark, J., and Muller, S., 1992, Multiple autoepitope presentation for specific detection of antibodies in primary biliary cirrhosis, Hepatology 6:1395–1403.

    Article  Google Scholar 

  • Brown, F. J., 1990, The potential of peptides as vaccines, Semin. Virol. 1:61–74.

    Google Scholar 

  • Callahan, K. M., Fort, M. M., Obah, E. A., Reinherz, E. L., and Siliciano, R. F., 1990, Genetic variability in HIV-1 gpl20 affects interactions with HLA molecules and T cell receptor, J. Immunol. 144:3341–3346.

    PubMed  CAS  Google Scholar 

  • Chai, S. K., Clavijo, P., Tarn, J. P., and Zavala, F., 1992, Immunogenic properties of multiple antigen peptide systems containing defined T and B epitopes, J. Immunol. 149:2385–2390.

    PubMed  CAS  Google Scholar 

  • Defoort, J.-P., Nardelli, B., Huang, W., Ho, D. D., and Tarn, J. P., 1992, Macromolecular assemblage in the design of a synthetic AIDS vaccine, Proc. Natl. Acad. Sci. USA 89:3879–3883.

    Article  PubMed  CAS  Google Scholar 

  • Del Giudice, G., Tougne, C., Louis, J. A., Lambert, P.-H., Bianchi, E., Bonelli, F., Chiappinelli, L., and Pessi, A., 1990, A multiple antigen peptide from the repetitive sequence of the Plasmodium malarie circumsporozoite protein induces a specific antibody response in mice of various H-2 haplotypes, Eur. J. Immunol. 20:1619–1622.

    Article  PubMed  Google Scholar 

  • Deres, K., Schild, H., Wiesmüller, K.-H., Jung, G., and Rammensee, H. G., 1989, In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine, Nature 342:561–564.

    Article  PubMed  CAS  Google Scholar 

  • Dyrberg, T., and Oldstone, M. B., 1986, Peptides as antigens: Importance of orientation, J. Exp. Med. 164:1344–1349.

    Article  PubMed  CAS  Google Scholar 

  • Flexner, C., 1990, New approaches to vaccination, Adv. Pharmacol. 21:51–99.

    Article  PubMed  CAS  Google Scholar 

  • Francis, M. J., Fry, C. M., Rowlands, D. J., Bittle, J. L., Houghten, R. A., Lerner, R. A., and Brown, F., 1987, Immune response to uncoupled peptides of foot-and-mouth disease virus, Immunology 61:1–6.

    PubMed  CAS  Google Scholar 

  • Francis, M. J., Hastings, G. Z., Brown, F., McDermed, J., Lu, Y.-A., and Tarn, J. P., 1991, Immunological evaluation of the multiple antigen peptide (MAP) system using the major immunogenic site of foot-and-mouth disease virus, Immunology 73:249–254.

    PubMed  CAS  Google Scholar 

  • Goudsmit, J., Debouck, C., Meloen, R. H., Smit, L., Bakker, M., Asher, D. M., Wolff, A. V., Gibbs, C. J., Jr., and Gajdusek, D. C., 1988, Human immunodeficiency virus type 1 neutralization epitope with conserved architecture elicits early type-specific antibodies in experimentally infected chimpanzees, Proc. Natl. Acad. Sci. USA 85:4478–4482.

    Article  PubMed  CAS  Google Scholar 

  • Green, N., Alexander, H., Olson, A., Alexander, S., Shinnick, T. M., Sutcliffe, J. G., and Lerner, R. A., 1982, Immunogenic structure of the influenza hemagglutinin, Cell 28:477–487.

    Article  PubMed  CAS  Google Scholar 

  • Habluetzel, A., Pessi, A., Bianchi, E., Rotigliano, G., and Esposito, F., 1991, Multiple antigen peptides for specific detection of antibodies to a malaria antigen in human sera, Immunol. Lett. 30:75–80.

    Article  PubMed  CAS  Google Scholar 

  • Harding, C.V., and Unanue, E. R., 1990, Cellular mechanisms of antigen processing and the function of class I and II major histocompatibility complex molecules, Cell. Regul. 1:499–509.

    PubMed  CAS  Google Scholar 

  • Herzenberg, L. A., and Tokuhisa, T., 1983, Epitope-specific regulation. I. Carrier-specific induction of suppression for IgG anti-hapten antibody responses, J. Exp. Med. 155:1730–1740.

    Article  Google Scholar 

  • Kamo, K., Jordan, R., Hsu, H.-T., and Hudson, D., 1992, Development of a monoclonal antibody to a conserved region of p34cdc2 protein kinase, J. Immunol. Methods 156:163–170.

    Article  PubMed  CAS  Google Scholar 

  • Kelker, H. C., Schlesinger, D., and Valentine, F. T., 1994, Immunogenic and antigenic properties of an HIV-1 gpl20-derived multiple chain peptide, J. Immunol. 152:4139–4148.

    PubMed  CAS  Google Scholar 

  • Kenealy, W. R., Matthews, T. J., Ganfield, M.-C., Langlois, A. J., Waselefsky, D. M., and Petteway, S. R., Jr., 1989, Antibodies from human immunodeficiency virus-infected individuals bind to a short amino acid sequence that elicits neutralizing antibodies in animals, AIDS Res. Hum. Retroviruses 5:173–182.

    Article  PubMed  CAS  Google Scholar 

  • Kumar, A., Arora, R., Kaur, P., Chauhan, V. S., and Sharma, P., 1992, “Universal” T helper cell determinants enhance immunogenicity of a Plasmodium falciparum merozoite surface antigen peptide, J. Immunol. 148:1499–1505.

    PubMed  CAS  Google Scholar 

  • Levi, M., Ruden, U., Birx, D., Loomis, L., Redfield, R., Lovgren, K., Akerblom, L., Sandstrom, E., and Wahren, B., 1993, Effects of adjuvants and multiple antigen peptides on humoral and cellular responses to gp 160 of HIV-1, J. Acquir. Immune Defic. Syndr. 6:855–864.

    PubMed  CAS  Google Scholar 

  • Lu, Y.-A., Clavijo, P., Galantino, M., Shen, Z.-Y., and Tarn, J. P., 1991, Chemically unambiguous peptide immunogen: Preparation, orientation and antigenicity of purified peptide conjugated to the multiple peptide system, Mol. Immunol. 28:623–630.

    Article  PubMed  CAS  Google Scholar 

  • Marguerite, M., Bossus, M., Mazingue, C., Wolowczuk, L., Grass-Masse, H., Tartar, A., Capron, A., and Auriault, C., 1992, Analysis of antigenicity and immunogenicity of five different chemically defined constructs of a peptide, Mol. Immunol. 29:793–800.

    Article  PubMed  CAS  Google Scholar 

  • Marsden, H. S., Owsianka, A. M., Graham, S., McLean, G. W., Robertson, C. A., and Subak-Sharpe, J. H., 1992, Advantages of branched peptides in serodiagnosis. Detection of HIV-specific antibodies and use of glycine spacers to increase sensitivity, J. Immunol. Methods 147:65–72.

    Article  PubMed  CAS  Google Scholar 

  • Munesinghe, D. Y., Clavijo, P., Calvo Calle, M., Nussenzweig, R. S., and Nardin, E., 1991, Immunogenicity of multiple antigen peptides (MAP) containing T and B cell epitopes of the repeat region of the P. falciparum circumsporozoite protein, Eur. J. Immunol. 21:3015–3020.

    Article  PubMed  CAS  Google Scholar 

  • Nardelli, B., and Tarn, J. P., 1993, Cellular immune responses induced by in vivo priming with a lipid-conjugated multimeric antigen peptide, Immunology 79:355–361.

    PubMed  CAS  Google Scholar 

  • Nardelli, B., Lu, Y.-A., Shiu, D. R., Delpierre-Defoort, C., Profy, A. T., and Tarn, J. P., 1992a, A chemically defined synthetic vaccine model for HIV-1, J. Immunol. 148:914–920.

    PubMed  CAS  Google Scholar 

  • Nardelli, B., Defoort, J.-P., Huang, W., and Tarn, J. P., 1992b, Design of a complete synthetic peptide-based AIDS vaccine with a built-in adjuvant, AIDS Res. Hum. Retrovimses 8:1405–1407.

    CAS  Google Scholar 

  • Nardelli, B., Haser, P. B., and Tarn, J. P., 1994, Oral administration of an antigenic synthetic lipopeptide (MAP-P3C) evokes salivary antibodies and systemic humoral and cellular responses, Vaccine 12:1335–1339.

    Article  PubMed  CAS  Google Scholar 

  • Palker, T. J., Clark, M. E., Langlois, A. J., Matthews, T. J., Weinhold, K. J., Randall, R. R., Bolognesi, D. P., and Haynes, B. F., 1988, Type-specific neutralization of the human immunodeficiency virus with antibodies to env-encoded synthetic peptides, Proc. Notl. Acad. Sci. USA 85:1932–1936.

    Article  CAS  Google Scholar 

  • Palker, T. J., Matthews, T. J., Langlois, A., Tanner, M. E., Martin, M. E., Scearce, R. M., Kim, J. E., Berzofsky, J. A., Bolognesi, D. P., and Haynes, B. F., 1989, Polyvalent human immunodeficiency virus synthetic immunogen comprised of envelope gp 120 T helper cell sites and B cell neutralization epitopes, J. Immunol. 142:3612–3619.

    PubMed  CAS  Google Scholar 

  • Panina-Bordignon, P., Tan, A., Termijtelen, A., Demotz, S., Corradin, G., and Lanzavecchia, A., 1989, Universal immunogenic T cell epitopes: Promiscuous binding to human MHC class II and promiscuous recognition by T cells, Eur. J. Immunol. 19:2237–2242.

    Article  PubMed  CAS  Google Scholar 

  • Pessi, A., Valmori, D., Migliorini, P., Tougne, C., Bianchi, E., Lambert, P.-H., Corradin, G., and Del Giudice, G., 1991, Lack of H-2 restriction of the Plasmodium falciparum (NANP) sequence as multiple antigen peptide, Eur. J. Immunol. 21:2273–2276.

    Article  PubMed  CAS  Google Scholar 

  • Posnett, D. N., McGrath, H., and Tarn, J. P., 1988, A novel method for producing anti-peptide antibodies, J. Biol. Chem. 263:1719–1725.

    PubMed  CAS  Google Scholar 

  • Reitermann, A., Metzger, J., Wiesmüller, K.-H., Jung, G., and Bessler, W. G., 1989, Lipopeptide derivatives of bacterial lipoprotein constitute potent immune adjuvant combined or covalently coupled to antigen or hapten, Biol. Chem. Hoppe-Sey1er 370:343–352.

    Article  CAS  Google Scholar 

  • Robinson, J. H., and Kehoe, M. A., 1992, Group A streptococcal M proteins: Virulence factors and protective antigens, Immunol. Today 13:362–366.

    Article  PubMed  CAS  Google Scholar 

  • Robinson, W. E., Jr., Kawamura, T., Gorny, M. K., Lake, D., Xu, J.-Y., Matsumoto, Y., Sugano, T., Masuho, Y., Mitchell, W. M., Hersh, E., and Zolla-Pazner, S., 1990, Human monoclonal antibodies to the human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein gp41 enhance HIV-1 infection in vitro, Proc. Natl. Acad. Sci. USA 87:3185–3189.

    Article  PubMed  CAS  Google Scholar 

  • Roche, P. A., and Cresswell, P., 1990, High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR, J. Immunol. 144:1849–1856.

    PubMed  CAS  Google Scholar 

  • Rusche, J. R., Javaherian, K., McDanal, C., Petro, J., Lynn, D. L., Grimaila, R., Langlois, A., Gallo, R. C., Arthur, L. O., Fischinger, P. J., Bolognesi, D. P., Putney, S. D., and Matthews, T. J., 1988, Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gpl20, Proc. Natl. Acad. Sci. USA 85:3198–3202.

    Article  PubMed  CAS  Google Scholar 

  • Scnder, R. D., Gnann, J. W., Jr., Landes, R., Lockshin, C., Richman, D., McCutchan, A., Kennedy, C., Oldstone, M. B. A., and Nelson, J. A., 1989, T cell recognition of HIV synthetic peptides in a natural infection, J. Immunol. 142:1166–1176.

    Google Scholar 

  • Schutze, M.-P., Leclerc, C., Jolivet, M., Audibert, F., and Chedid, L., 1985, Carrier-induced epitopic suppression, a major issue for future synthetic vaccines, J. Immunol. 135:2319–2322.

    PubMed  CAS  Google Scholar 

  • Schwartz, R. H., 1985, T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex, Annu. Rev. Immunol. 3:237–261.

    Article  PubMed  CAS  Google Scholar 

  • Sinigaglia, F., Guttinger, M., Kilgus, J., Doran, D. M., Matilde, H., Etlinger, H., Trzeciak, A., Gillesen, D., and Pink, J. R. L., 1988, A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules, Nature 336:778–780.

    Article  PubMed  CAS  Google Scholar 

  • Takahashi, H., Cohen, J., Hosmalin, A., Cease, K. B., Houghten, R., Cornette, J. L., DeLisi, C., Moss, B., Germain, R. N., and Berzofsky, J. A., 1988, An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp 160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes, Proc. Natl. Acad. Sci. USA 85:3105–3109.

    Article  PubMed  CAS  Google Scholar 

  • Tarn, J. P., 1988, Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system, Proc. Natl. Acad. Sci. USA 85:5409–5413.

    Article  Google Scholar 

  • Tarn, J. P., 1993, U.S. Patent 5,229,490, Multiple Antigen Peptide System.

    Google Scholar 

  • Tarn, J. P., and Lu, Y.-A., 1989, Vaccine engineering: Enhancement of immunogenicity of synthetic peptide vaccines related to hepatitis in chemically defined models consisting of T-and B-cell epitopes, Proc. Natl. Acad. Sci. USA 86:9084–9088.

    Article  Google Scholar 

  • Tarn, J. P., and Zavala, F., 1989, Multiple antigen peptide. A novel approach to increase detection sensitivity of synthetic peptides in solid-phase immunoassays, J. Immunol. Methods 124:53–61.

    Article  Google Scholar 

  • Tarn, J. P., Clavijo, P., Lu, Y.-A., Nussenzweig, V., Nussenzweig, R., and Zavala, F., 1990, Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria, J. Exp. Med. 171:299–306.

    Article  Google Scholar 

  • Troalen, F., Razafindratsita, A., Puisieux, A., Voeltzel, T., Bohuon, C., Bellet, D., and Bidart, J.-M., 1990, Structural probing of human lutropin using antibodies against synthetic peptides constructed by classical and multiple antigen peptide system approach, Mol. Immunol. 27:363–368.

    Article  PubMed  CAS  Google Scholar 

  • Wang, C. Y., 1989, European Patent Application 89,301,288.0.

    Google Scholar 

  • Wang, C. Y., Looney, D. J., Li, M. L., Walfield, A. M., Ye, J., Hosein, B., Tarn, J. P., and Wong-Staal, F., 1991, Long-term high-titer neutralizing activity induced by octameric synthetic HIV-1 antigen, Science 254:285–288.

    Article  PubMed  CAS  Google Scholar 

  • Wiesmüller, K.-H., Bessler, W. G., and Jung, G., 1983, Synthesis of the mitogenic S-[2,3-bis(palmitoyloxy)propyl]-N-palmitoyl pentapeptide from the Escherichia coli lipoprotein, Hoppe Seyler’s Z. Physiol. Chem. 364:593–606.

    Article  PubMed  Google Scholar 

  • Wolowczuk, I., Auriault, C., Bossus, M., Boulanger, D., Gras-Masse, H., Mazingue, C., Pierce, R. J., Grezel, D., Reid, G. D., Tartar, A., and Capron, A., 1991, Antigenicity and immunogenicity of a multiple peptidic construction of the Schistosoma mansoni Sm-28 GST antigen in rat, mouse, and monkey. 1. Partial protection of Fisher rat after active immunization, J. Immunol. 146:1987–1995.

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Medicine Department, Infectious Diseases Division, New York University Medical Center, New York, New York, 10016, USA

    Bernardetta Nardelli

  2. Microbiology and Immunology Department, Vanderbilt University, Nashville, Tennessee, 37232, USA

    James P. Tam

Authors
  1. Bernardetta Nardelli
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  2. James P. Tam
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Editor information

Editors and Affiliations

  1. Genentech, Inc., South San Francisco, California, USA

    Michael F. Powell

  2. Vaxcel, Inc., Norcross, Georgia, USA

    Mark J. Newman

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Nardelli, B., Tam, J.P. (1995). The MAP System. In: Powell, M.F., Newman, M.J. (eds) Vaccine Design. Pharmaceutical Biotechnology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1823-5_36

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  • DOI: https://doi.org/10.1007/978-1-4615-1823-5_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5737-7

  • Online ISBN: 978-1-4615-1823-5

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