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Vaccine Research and Development for the Prevention of Filarial Nematode Infections

  • Chapter
Vaccine Design

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 6))

Abstract

Filarial nematodes constitute a group of pathogens with extraordinary medical and veterinary medical importance. The lymphatic filariae of humans affect almost 90 million people worldwide (Ottesen, 1992). Onchocerciasis is a major cause of infectious blindness, affecting nearly 50 million people in sub-Saharan Africa and the Americas and resulting in blindness in about 1 million people (Taylor, 1985).

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References

  • Abraham, D., and Grieve, R. B., 1991, Passive transfer of protective immunity to larval Dirofilaria immitis from dogs to BALB/c mice, J. Parasitol. 77:254–257.

    Article  PubMed  CAS  Google Scholar 

  • Abraham, D., Weiner, D. J., and Farrell, J. P., 1986a, Cellular and humoral immune responses of jirds resistant to Dipetalonema viteae infection, Infect. Immun. 52:742–747.

    PubMed  CAS  Google Scholar 

  • Abraham, D., Weiner, D. J., and Farrell, J. P., 1986b, Protective immune responses of the jird to larval Dipetalonema viteae, Immunology 57:165–169.

    PubMed  CAS  Google Scholar 

  • Abraham, D., Grieve, R. B., Mika-Grieve, M., and Seibert, M., 1988a, Active and passive immunization of mice against larval Dirofilaria immitis, J. Parasitol. 74:275–282.

    Article  PubMed  CAS  Google Scholar 

  • Abraham, D., Grieve, R. B., and Mika-Grieve, M., 1988b, Dirofilaria immitis: Surface properties of third-and fourth-stage larvae, Exp. Parasitol. 65:157–167.

    Article  PubMed  CAS  Google Scholar 

  • Abraham, D., Grieve, R. B., Holy, J. M., and Christensen, B. ML, 1989, Immunity to larval Brugia malayi in BALB/c mice: Protective immunity and inhibition of larval development, Am. J. Trop. Med. Hyg. 40:598–604.

    PubMed  CAS  Google Scholar 

  • Abraham, D., Eberhard, M. L., Lange, A. M., Yutanawiboonchai, W., Perler, F., and Lok, J. B., 1992, Identification of surrogate rodent hosts for larval Onchocerca lienalis and induction of protective immunity in a model system, J. Parasitol. 78:447–453.

    Article  PubMed  CAS  Google Scholar 

  • Ah, H. S., McCall, J. W., and Thompson, P. E., 1974, A simple method for isolation of Brugia pahangi and Brugia malayi microfilariae, Int. J. Parasitol. 4:677–679.

    Article  PubMed  CAS  Google Scholar 

  • Alarcon, C. M., and Donelson, J. E., 1991, Translational elongation factor 1 alpha (EF-1alpha) of Onchocerca volvulus, Mol. Biochem. Parasitol. 48:105–108.

    Article  PubMed  CAS  Google Scholar 

  • Apfel, H., Eisenbeiss, W. F., and Meyer, T. F., 1992, Changes in the surface composition after transmission of Acanthocheilonema viteae third stage larvae into the jird, Mol. Biochem. Parasitol. 52:63–74.

    Article  PubMed  CAS  Google Scholar 

  • Arasu, P., Nutman, T. B., Steel, C., Mulligan, M., Abraham, D., Tuan, R., and Perler, F. B., 1989, Human T-cell stimulation, molecular characterization and in situ mRNA localization of a Brugia malayi recombinant antigen, Mol. Biochem. Parasitol. 36:223–232

    Article  PubMed  CAS  Google Scholar 

  • Awobuluyi, M., Maina, C., and Carlow, C., 1991, Cross-linking of a monoclonal antibody-antigen complex enables detection of parasite antigen in immunoblots and in an expression library, Mol. Biochem. Parasitol. 44:149–152.

    Article  PubMed  CAS  Google Scholar 

  • Bagai, R. C., and Subrahmanyam, D., 1970, Nature of acquired resistance to filarial infectin in albino rats Nature 228:682–683.

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, C. I., De Medeiros, F., and Denham, D. A., 1993, IgE responses in cats infected with Brugia pahangi, Parasite Immunol. 15:291–296.

    Article  PubMed  CAS  Google Scholar 

  • Bancroft, A. J., and Devaney, E., 1993, The analysis of the humoral response of the BALB/c mouse immunized with radiation attenuated third stage larvae of Brugia pahangi, Parasite Immunol. 15:153–162.

    Article  PubMed  CAS  Google Scholar 

  • Bancroft, A. J., Grencis, R., Else, K., and Devaney, E., 1993, Cytokine production in BALB/c mice immunized with radiation attenuated third stage larvae of the filarial nematode, Brugia pahangi, J. Immunol. 150:1359–1402.

    Google Scholar 

  • Barthold, E., and Wenk, P., 1992, Dose-dependent recovery of adult Acanthocheilonema viteae (Nematoda: Filarioidea) after single and trickle inoculations in jirds, Parasitol. Res. 78:229–234.

    Article  PubMed  CAS  Google Scholar 

  • Bartlett, A., Turk, J., Ngu, J. L., Mackenzie, C. S., Fuglsang, H., and Anderson, J., 1978, Variation in delayed hypersensitivity in onchocerciasis, Trans. R. Soc. Trop. Med. Hyg. 72:372–377.

    Article  PubMed  CAS  Google Scholar 

  • Blair, L. S., and Campbell, W. C., 1980, Suppression of maturation of Dirofilaria immitis in Mustela putorius furo by single dose of ivermectin, J. Parasitol. 66:691–692.

    Article  PubMed  CAS  Google Scholar 

  • Blair, L. S., and Campbell, W. C., 1981, Immunization of ferrets against Dirofilaria immitis by means of chemically abbreviated infections, Parasite Immunol. 3:143–147.

    Article  PubMed  CAS  Google Scholar 

  • Boyer, A. E., Tsang, V. C. W., Eberhard, M. L., Zea-Flores, G., Hightower, A., Pilcher, J. B., Zea-Flores, R., Zhou, W., and Reimer, C. B., 1991, Guatemalan human onchocerciasis: Evidence for IgG3 involvement in acquired immunity to Onchocerca volvulus and identification of possible immune-associated antigens, J. Immunol. 146:4001–4010.

    PubMed  CAS  Google Scholar 

  • Bradley, J. E., Helm, R., Lahaise, M., and Maizels, R. M., 1991, cDNA clones of Onchocerca volvulus low molecular weight antigens provide immunologically specific diagnostic probes, Mol. Biochem. Parasitol. 46:219–228.

    Article  PubMed  CAS  Google Scholar 

  • Bradley, J., Tuan, R., Shepley, K., Tree, T., Maizels, R., Helm, R., Gregory, W., and Unnasch, T., 1993, Onchocerca volvulus: Characterization of an immunodominant hypodermal antigen present in adult and larval parasites, Exp. Parasitol. 77:414–424.

    Article  PubMed  CAS  Google Scholar 

  • Braun, G., McKechnie, N. M., Connor, V., Gilbert, C. E., Engelbrecht, F., Whitworth, J. A., and Taylor, D. W., 1991, Immunological crossreactivity between a cloned antigen of Onchocerca volvulus and a component of the retinal pigment epithelium, J. Exp. Med. 174: 169–177.

    Article  PubMed  CAS  Google Scholar 

  • Buttner, D. W., Laer, V. Laer, G., Mannweiler, E., and Buttner, M., 1982, Clinical, parasitological and serological studies on onchocerciasis in the Yemen Arab Republic, Tropenmed. Parasitol. 33:201–212.

    PubMed  CAS  Google Scholar 

  • Carlow, C. K. S., and Bianco, A. E., 1987, Transfer of immunity to the microfilariae of Onchocerca lienalis in mice, Trop. Med. Parasitol. 39:283–286.

    Google Scholar 

  • Carlow, C. K. S., and Philipp, M., 1987, Protective immunity to Brugia malayi larvae in Balb/c mice: Potential of this model for the identification of protective antigens, Am. J. Trop. Med. Hyg. 37:597–604.

    PubMed  CAS  Google Scholar 

  • Carlow, C. K., Franke, E. D., Lowrie, R. C., Partono, F., and Philipp, M., 1987, Monoclonal antibody to a unique surface epitope of the human filaria Brugia malayi identifies infective larvae in mosquito vectors, Proc. Natl. Acad. Sci. USA 84:6914–6918.

    Article  PubMed  CAS  Google Scholar 

  • Carlow, C. K. S., Dobinson, A. R., and Bianco, A. E., 1988, Parasite-specific immune responses to Onchocerca lienalis microfilariae in normal and immunodeficient mice, Parasite Immunol. 10:309–322.

    Article  PubMed  CAS  Google Scholar 

  • Caulagi, V., Werner, C., and Rajan, T., 1991, Isolation and partial sequence of a collagen gene from the human filarial parasite, Brugia malayi, Mol. Biochem. Parasitol. 45:57–64.

    Article  PubMed  CAS  Google Scholar 

  • Chandrashekar, R., Masood, K., Alvarez, R. M., Ogunrinade, A. F., Lujan, R., Richards, J., and Weil, G. J., 1991, Molecular cloning and characterization of recombinant parasite antigens for immunodiagnosis of onchocerciasis, J. Clin. Invest. 88:1460–1466.

    Article  PubMed  CAS  Google Scholar 

  • Chusattayanond, W., and Denham, D. A., 1986, Attempted vaccination of jirds against Brugia pahangi with radiation attenuated infective larvae, J. Helminthol. 60:149–155.

    Article  PubMed  CAS  Google Scholar 

  • Colina, K. F., Perler, F. B., Matsumura, I., Meda, M., and Nutman, T. B., 1990, The identification of an Onchocerca-specific recombinant antigen containing a T cell epitope, J. Immunol. 145:1551–1556.

    PubMed  CAS  Google Scholar 

  • Conraths, F. J., Worms, M. J., Preece, G., Harnett, W., and Parkhouse, R. M. E., 1991, Studies on a 14-kilodalton surface protein of Onchocerca microfilariae, Mol. Biochem. Parasitol. 46:103–112.

    Article  PubMed  CAS  Google Scholar 

  • Conraths, F. J., Harnett, H. W., Worms, M. J., and Parkhouse, R. M. E., 1992, Immunological cross-reaction between an Onchocerca paramyosin-like molecule and microfilaria surface antigen, Trop. Med. Parasitol. 43:135–138.

    PubMed  CAS  Google Scholar 

  • Cookson, E., Blaxter, M. L., and Selkirk, M., 1992, Identification of the major soluble cuticular glycoprotein of lymphatic filarial nematode parasite (gp29) as a secretory homolog of glutathione peroxidase, Proc. Natl. Acad. Sci. USA 89: 5837–5841.

    Article  PubMed  CAS  Google Scholar 

  • Cookson, E., Tang, L., and Selkirk, M. E., 1993, Conservation of primary sequence of gp29, the major soluble cuticular glycoprotein, in three species of lymphatic filariae, Mol. Biochem. Parasitol. 58: 155–160.

    Article  PubMed  CAS  Google Scholar 

  • Culpepper, J., Grieve, R. B., Friedman, L. B., Mika-Grieve, M., Frank, G. R., and Dale, B., 1992, Molecular characterization of a Dirofilaria immitis cDNA encoding a highly immunoreactive antigen, Mol. Biochem. Parasitol. 54: 51–62.

    Article  PubMed  CAS  Google Scholar 

  • Dahmen, A., Gallin, M., Schumaucher, M., and Erttmann, K., 1993, Molecular cloning and pre-mRNA maturation of Onchocerca volvulus paramyosin, Mol. Biochem. Parasitol. 57:335–338.

    Article  PubMed  CAS  Google Scholar 

  • Day, K. P., 1991, The endemic normal in lymphatic filariasis: A static concept, Parasitol. Today 7:341–343.

    Article  PubMed  CAS  Google Scholar 

  • Day, K. P., Gregory, W. F., and Maizels, R. M., 1991a, Age-specific acquisition of immunity to infective larvae in a bancroftian filariasis endemic area of Papua New Guinea, Parasite Immunol. 13:277–290.

    Article  PubMed  CAS  Google Scholar 

  • Day, K. P., Grenfell, B., Spark, R., Kazura, J. W., and Alpers, M. P., 1991b, Age specific patterns of change in the dynamics of Wuchereria bancrofti infection in Papua, New Guinea, Am. J. Trop. Med. Hyg. 44:518–527.

    PubMed  CAS  Google Scholar 

  • Day, K. P., Spark, R., Garner, P., Raiko, A., Wenger, J. D., Weiss, N., Mitchell, G. F., Alpers, M. P., and Kazura, J. W., 1991c, Serological evaluation of the macrofilaricidal effects of diethylcarbamazine treatment in bancroftian filariasis, Am. J. Trop. Med. Hyg. 44:528–535.

    PubMed  CAS  Google Scholar 

  • Denham, D. A., Ponnudurai, T., Nelson, G. S., Guy, F., and Rogers, R., 1972a, Studies with Brugiapahangi: Parasitological observations on primary infections of cats, Int. J. Parasitol. 2:239–247.

    Article  PubMed  CAS  Google Scholar 

  • Denham, D. A., Ponnudurai, T., Nelson, G. S., Guy, F., and Rogers, R., 1972b, Studies with Brugia pahangi: The effect of repeated infection on parasite levels in cats, Int. J. Parasitol. 2:401–407.

    Article  PubMed  CAS  Google Scholar 

  • Denham, D. A., McGreevy, P. B., Suswillo, R. R., and Rogers, R., 1983, The reistance to re-infection of cats repeatedly inoculated with infective larvae of Brugia pahangi, Parasitology 86: 11–18.

    Article  PubMed  Google Scholar 

  • Denham, D. A., Medeiros, F., Baldwin, C., Kumar, H., Midwinter, I. C. T., Birch, D. W., and Smail, A., 1992, Repeated infection of cats with Brugia pahangi: Parasitological observations, Parasitology 104:415–420.

    Article  PubMed  Google Scholar 

  • Devaney, E., Bancroft, A., and Egan, A., 1993, The effect of irradiation on the third stage larvae of Brugia pahangi, Parasite Immunol. 15:423–427.

    Article  PubMed  CAS  Google Scholar 

  • Dinman, J. D., and Scott, A. L., 1990, Onchocerca volvulus: Molecular cloning, primary structure, and expression of a microfilarial surface-associated antigen, Exp. Parasitol. 71:176–188.

    Article  PubMed  CAS  Google Scholar 

  • Dissanayake, S., Xu, M., and Piessens, W., 1992a, Myosin heavy chain is a dominant parasite antigen recognized by antibodies in sera from donors with filarial infections, Mol. Biochem. Parasitol. 56:349–352.

    Article  PubMed  CAS  Google Scholar 

  • Dissanayake, S., Xu, M., and Piessens, W., 1992b, Filarial parasites contain a ras homolog of the TC4/ran/Spi 1 family, Mol. Biochem. Parasitol. 56:259–268.

    Article  PubMed  CAS  Google Scholar 

  • Dissanayake, S., Xu, M., and Piessens, W., 1992c, A cloned antigen for serological diagnosis of Wuchereria bancrofti microfilaremia with daytime blood samples, Mol. Biochem. Parasitol. 56:269–278.

    Article  PubMed  CAS  Google Scholar 

  • Dissanayake, S., Xu, M., Nkenfou, C., and Piessens, W., 1993, Molecular cloning and serological characterization of a Brugia malayi pepsin inhibitor homolog, Mol. Biochem. Parasitol. 62:143–146.

    Article  PubMed  CAS  Google Scholar 

  • Donelson, J. E., Duke, B. O. L., Moser, D., Zeng, W., Erondu, N., Lucius, R., Renz, A., Karam, M., and Flores, G., 1988, Construction of Onchocerca volvulus cDNA libraries and partial characterization of the cDNA for a major antigen, Mol. Biochem. Parasitol. 31:241–250.

    Article  PubMed  CAS  Google Scholar 

  • Duke, B. O. L., 1968, Reinfections with Onchocerca volvulus in cured patients exposed to continuing transmission, Bull. WHO 39:307–309.

    PubMed  CAS  Google Scholar 

  • Duke, B. O. L., and Moore, P. T., 1968, The contribution of different age groups to the transmission of onchocerciasis in a Cameroon forest village, Trans. R. Soc. Trop. Med. Hyg. 62:22–28.

    Article  PubMed  CAS  Google Scholar 

  • Egerton, J. R., Birnbaum, J., Blair, L. S., Chabala, J. C., Conroy, J., Fisher, M. H., Mrozik, H., Ostlind, D. A., Wilkins, C. A., and Campbell, W. C., 1980, 22,23-dihydroavermectin Bla, a new broad-spectrum antiparasitic agent, Br. Vet. J. 136:88–97.

    PubMed  CAS  Google Scholar 

  • Eisenbeiss, W. F., Apfel, H., and Meyer, F., 1994, Protective immunity linked with a distinct developmental stage of filarial parasite, J. Immunol. 22:735–742.

    Google Scholar 

  • Elson, L., Guderian, R., Araujo, E., Bradley, J., Days, A., and Nutman, T., 1994, Immunity to onchocerciasis: Identification of a putatively immune population in a hyperendemic area of Ecuador, J. Infect. Dis. 169:588–594.

    Article  PubMed  CAS  Google Scholar 

  • Erondu, N. E., and Donelson, J. E., 1990, Characterization of a myosin-like antigen from Onchocerca volvulus, Mol. Biochem. Parasitol. 40:213–224

    Article  PubMed  CAS  Google Scholar 

  • Fletcher, C., Birch, D. W., and Denham, D. A., 1992, Cats with single Brugia pahangi infections: Relationship between parasitological status and humoral responses to somatic and surface parasite antigens, Parasite Immunol. 14:339–350.

    Article  PubMed  CAS  Google Scholar 

  • Frank, G. R., and Grieve, R. B., 1991, Metabolic labeling of Dirofilaria immitis third-and fourth-stage larvae and their excretory-secretory products, J. Parasitol. 77:950–956.

    Article  PubMed  CAS  Google Scholar 

  • Freedman, D. O., Nutman, T. B., and Ottesen, E. A., 1989, Protective immunity in bancroftian filariasis: Selective recognition of a 43-kD larval stage antigen by infection-free individuals in an endemic area, J. Clin. Invest. 83:14–22.

    Article  PubMed  CAS  Google Scholar 

  • Fuhrman, J. A., Lane, W. S., Smith, R. F., Piessen, W. F., and Perler, F. B., 1992, Transmission-blocking antibodies recognize microfilarial chitinase in brugian lymphatic Filariasis, Proc. Natl. Acad. Sci. USA 89:1548–1552.

    Article  PubMed  CAS  Google Scholar 

  • Gallin, M. Y., Tan, M., Kron, M. A., Rechnitzer, D., Greene, B. M., Newland, H. S., White, A. T., Taylor, H. R., and Unnasch, T. R., 1989, Onchocerca volvulus recombinant antigen: Physical characterization and clinical correlates with serum reactivity, J. Infect. Dis. 160:521–529.

    Article  PubMed  CAS  Google Scholar 

  • Grandea, A. G., Tuyen, L. K., Asikin, N., Davis, T., Philipp, M., Cohen, C., and McReynolds, L., 1989, A λgtll cDNA recombinant that encodes Dirofilaria immitis paramyosin, Mol. Biochem. Parasitol. 35:31–42.

    Article  PubMed  CAS  Google Scholar 

  • Greene, B. M., Taylor, H. R., and Aikawa, M., 1981, Cellular killing of microfilariae of Onchocerca volvulus: Eosinophil and neutrophil mediated immune serum-dependent destruction, J. Immunol. 127:1611–1618.

    PubMed  CAS  Google Scholar 

  • Greene, B., Gbakina, A., Albiez, E., and Taylor, H., 1985, Humoral and cellular immune responses to Onchocerca volvulus infection in humans, Rev. Infect. Dis. 7:789–795.

    Article  PubMed  CAS  Google Scholar 

  • Grenfell, B. T., Michael, E., and Denham, D. A., 1991, A model for the dynamics of human lymphatic filariasis, Parasitol. Today 7:318–323.

    Article  PubMed  CAS  Google Scholar 

  • Grieve, R. B., Brooks, B. O., Babish, J. G., Jacobson, R. H., and Cypess, R. H., 1982, Lymphocyte function in experimental canine dirofilariasis: B-cell responses to heterologous antigen, J. Parasitol. 68:341–343.

    Article  PubMed  CAS  Google Scholar 

  • Grieve, R. B., Lok, J. B., and Glickman, L. T., 1983, Epidemiology of canine heartworm infection, Epidemiol. Rev. 5:220–246.

    PubMed  CAS  Google Scholar 

  • Grieve, R. B., Abraham, D., Mika-Grieve, M., and Seibert, B. P., 1988, Induction of protective immunity in dogs to infection with Dirofilaria immitis using chemically-abbreviated infections, Am. J. Trop. Med. Hyg. 39:373–379.

    PubMed  CAS  Google Scholar 

  • Grieve, R. B., Frank, G. R., Stewart, V. A., Parsons, J. C., Belasco, D. L., and Hepler, D. I., 1991, Chemoprophylactic effects of milbemycin oxime against larvae of Dirofilaria immitis during prepatent development, Am. J. Vet. Res. 52:2040–2042.

    PubMed  CAS  Google Scholar 

  • Grieve, R. B., Frank, G. R., Mika-Grieve, M., Culpepper, J. A., and Mok, M., 1992, Identification of Dirofilaria immitis larval antigens with immunoprophylactic potential using sera from immune dogs, J. Immunol. 148:2511–2515.

    PubMed  CAS  Google Scholar 

  • Guenette, S., Prichard, R. K., Klein, R. D., and Matlashewski, G., 1991, Characterization of a beta-tubnlin gene and beta-tubulin gene products of Brugia pahangi, Mol. Biochem. Parasitol. 44:153–164.

    Article  PubMed  CAS  Google Scholar 

  • Guenette, S., Prichard, R. K., and Matlashewski, G., 1992, Identification of a novel Brugia pahangi beta-tubnlin gene (B-2) and a 22-nucleotide spliced leader sequence on beta-tubnlin mRNA, Mol. Biochem. Parasitol. 50:275–284.

    Article  PubMed  CAS  Google Scholar 

  • Haque, A., Chassoux, D., Ogilvie, B. M., and Capron, A., 1978, Dipetalonema viteae infections in hamsters: Enhancement and suppression of microfilaraemia, Parasitology 76:61–75.

    Article  PubMed  CAS  Google Scholar 

  • Haque, A., Quaissi, A., Santoro, F., Des Moutis, I., and Capron, A., 1982, Complement-mediated leukocyte adherence to infective larvae of Dipetalonema viteae (Filariodea): Requirement for eosinophils or eosinophil products in effecting macrophage adherence, J. Immunol. 129:2219–2225.

    PubMed  CAS  Google Scholar 

  • Hayashi, Y., Nogami, S., Nakamura, M., Shirasaka, A., and Noda, K., 1984, Passive transfer of protective immunity against Brugia malayiiin BALB/c mice, Jpn. J. Exp. Med. 54:183–187.

    PubMed  CAS  Google Scholar 

  • Hayashi, Y., Nakagaki, K., Nogami, S., Hammerberg, B., and Tanaka, H., 1989, Protective immunity against Brugia malayi infective larvae in mice: Parameters of active and passive immunity, Am. J. Trop. Med. Hyg. 41:650–656.

    PubMed  CAS  Google Scholar 

  • Helm, R., Selkirk, M. E., Bradley, J. E., Burns, R. G., Hamilton, A. J., Croft, S., and Maizels, R. M., 1989, Localization and immunogenicity of tubulin in the filarial nematodes Brugia malayi and B. pahangi, Parasite Immunol. 11:479–502.

    Article  PubMed  CAS  Google Scholar 

  • Henkle, K. J., Liebau, E., Muller, S., Bergmann, B., and Walter, R. D., 1991, Characterization and molecular cloning of a Cu/Zn Superoxide dismutase from the human parasite Onchocerca volvulus, Infect. Immun. 59:2063–2069.

    PubMed  CAS  Google Scholar 

  • Holst, C., and Zipfel, P. F., 1993, Identification of a zinc finger encoding gene in Onchocerca volvulus, Trop. Med. Parasitol. 44:147–151.

    PubMed  CAS  Google Scholar 

  • James, E., McLean, D., and Perler, F., 1994, Molecular cloning of an Onchocerca volvulus extracellular Cu-Zn Superoxide dismutase, Infect. Immun. 62:713–716.

    PubMed  CAS  Google Scholar 

  • Jarrett, W., Jennings, F., McIntyre, W., Mulligan, W., Sharp, N., and Urquhart, G., 1960, Immunological studies on Dictyocaulus viviparus infection, Immunology 3:145–151.

    PubMed  CAS  Google Scholar 

  • Kazura, J., and Davis, R. S., 1982, Soluble Brugia malayi microfilarial antigens protect mice against challenge by an antibody-dependent mechanism, J. Immunol. 128:1792–1796.

    PubMed  CAS  Google Scholar 

  • Kazura, J. W., Cicirello, H., and Forsyth, K., 1986a, Differential recognition of a protective filarial antigen by antibodies from humans with bancroftian filariasis, J. Clin. Invest. 77:1985–1992.

    Article  PubMed  CAS  Google Scholar 

  • Kazura, J. W., Cicirello, H., and McCall, J. W., 1986b, Induction of protection against Brugia malayi infection in jirds by microfilarial antigens, J. Immunol. 136:1422–1426.

    PubMed  CAS  Google Scholar 

  • King, C. L., Kumaraswarmi, V., Poindexter, R. W., Kumria, S., Jayaraman, K., Alling, D. W., Ottesen, E. A., and Nutman, T. B., 1992, Immunologic tolerance in lymphatic filariasis. Diminished parasitespecific T and B lymphocyte precursor frequency in the microfilaremic state, J. Clin. Invest. 89:1403–1410.

    Article  PubMed  CAS  Google Scholar 

  • King, C. L., Mahanty, S., Kumaraswami, V., Abrahams, J. S., Regunathan, J., Jayaraman, K., Ottesen, E. A., and Nutman, T. B., 1993, Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset, J. Clin. Invest. 92:1667–1673.

    Article  PubMed  CAS  Google Scholar 

  • Klei, T. R., McCall, J. W., and Malone, J. B., 1980, Evidence for increased susceptibility of Brugia pahangi-infected jirds to subsequent homologous infections, J. Helminthol. 54:161–165.

    Article  PubMed  CAS  Google Scholar 

  • Knight, D. H., 1977, Heartworm heart disease, Adv. Vet. Sci. Comp. Med. 21:107–149.

    PubMed  CAS  Google Scholar 

  • Knight, D. H., 1987, Heartworm infection, in: The Veterinary Clinics of North America, Vol. 17 (R. B. Grieve, ed.), Saunders, Philadelphia, pp. 1463–1518.

    Google Scholar 

  • Kowalski, J. C., and Ash, L. R., 1975, Repeated infections in Brugia pahangi in the jird, Meriones unguiculatus, Southeast Asian J. Trop. Med. Public Health 6:195–198.

    PubMed  CAS  Google Scholar 

  • Kron, M., Erttmann, K., Greene, B., and Unnasch, T., 1992, Characterization of a possible tRNA synthetase gene from Onchocerca volvulus, Mol. Biochem. Parasitol. 52:289–292.

    Article  PubMed  CAS  Google Scholar 

  • Kwan-Lim, G., Forsyth, K. P., and Maizels, R. M., 1990, Filarial-specific IgG4 response correlates with active Wuchereria bancrofti infection, J. Immunol. 145:4298–4305.

    PubMed  CAS  Google Scholar 

  • Lal, R. B., and Ottesen, E. A., 1988, Characterization of stage-specific antigens of infective larvae of the filarial parasite Brugia malayi, J. Immunol. 140:2032–2038.

    PubMed  CAS  Google Scholar 

  • Lange, A. M., Yutanawiboochai, W., Lok, J. B., Trpis, M., and Abraham, D., 1993, Induction of protective immunity against larval Onchocerca volvulus in a mouse model, Am. J. Trop. Med. Hyg. 49:783–788.

    PubMed  CAS  Google Scholar 

  • Lange, A. M., Yutanawiboochai, W., Scott, P., and Abraham, D., 1994, IL-4 and IL-5 dependent protective immunity to Onchocerca volvulus infective larvae in BALB/cBYJ mice, J. Immunol. 153:205–211.

    PubMed  CAS  Google Scholar 

  • Li, B., Chandrashekar, R., Alvarez, R. M., Liftis, F., and Weil, G. J., 1991, Identification of paramyosin as a potential protective antigen against Brugia malayi infection in jirds, Mol. Biochem. Parasitol. 49:315–324.

    Article  PubMed  CAS  Google Scholar 

  • Li, B., Ramaswamy, C., and Weil, G., 1993, Vaccination with recombinant filarial paramyosin induces partial immunity to Brugia malayi infection in jirds, J. Immunol. 150:1881–1885.

    PubMed  CAS  Google Scholar 

  • Liebau, E., Walter, R. D., and Henkle-Duhrsen, K., 1994, Isolation, sequence and expression of an Onchocerca volvulus glutathione S-transferase cDNA, Mol. Biochem. Parasitol. 63:305–309.

    Article  PubMed  CAS  Google Scholar 

  • Limberger, R. J., and McReynolds, L. A., 1990, Filarial paramyosin: cDNA sequences from Dirofilaria immitis and Onchocerca volvulus, Mol. Biochem. Parasitol. 38:271–280.

    Article  PubMed  CAS  Google Scholar 

  • Lobos, E., Altmann, M., Mengod, G., Weiss, N., Rudin, W., and Karam, M., 1990, Identification of an Onchocerca volvulus cDNA encoding a low-molecular-weight antigen uniquely recognized by onchocerciasis patient sera, Mol. Biochem. Parasitol. 39:135–146.

    Article  PubMed  CAS  Google Scholar 

  • Lucius, R., Ruppel, A., and Diesfeld, H. J., 1986, Dipetalonema viteae: Resistance in Meriones unguiculatusi with multiple infections of stage-3 larvae, Exp. Parasitol. 62:237–246.

    Article  PubMed  CAS  Google Scholar 

  • Lucius, R., Erondu, N., Kern, A., and Donelson, J. E., 1988, Molecular cloning of an immunodominant antigen of Onchocerca volvulus, J. Exp. Med. 168:1199–1204.

    Article  PubMed  CAS  Google Scholar 

  • Lucius, R., Textor, G., Kern, A., and Kirsten, C., 1991, Acanthocheilonema viteae: Vaccination of jirds with irradiation-attenuated stage-3 larvae and with exported larval antigens, Exp. Parasitol. 73:184–196.

    Article  PubMed  CAS  Google Scholar 

  • Lustigman, S., Brotman, B., Huima, T., and Prince, A. M., 1991, Characterization of an Onchocerca volvulus cDNA clone encoding a genus specific antigen present in infective larvae and adult worms, Mol. Biochem. Parasitol. 45:65–76.

    Article  PubMed  CAS  Google Scholar 

  • Lustigman, S., Brotman, B., Huima, T., Prince, A. M., and McKerrow, J. H., 1992a, Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus, J. Biol. Chem. 267: 1734–1739

    Google Scholar 

  • Lustigman, S., Brotman, B., Johnson, E. H., Smith, A. B., Huima, T., and Prince, A. M., 1992b, Identification and characterization of an Onchocerca volvulusicDNA clone encoding a microfilarial surface-associated antigen, Mol. Biochem. Parasitol. 50:79–94.

    Article  PubMed  CAS  Google Scholar 

  • Maizels, R. M., and Lawrence, R. A., 1991, Immunological tolerance: The key feature in human filariasis, Parasitol Today 7:271–276.

    Article  PubMed  CAS  Google Scholar 

  • Maizels, R. M., Partono, F., Oemijati, S., Denham, D. A., and Ogilvie, B. M., 1983, Cross-reactive surface antigens on three stages of Brugia malayi, B. pahangi and B. timori, Parasitology 87:249–263.

    Article  PubMed  CAS  Google Scholar 

  • Maizels, R. M., Burke, J., and Denham, D. A., 1987, Phosphorylcholine-bearing antigens in filarial nematode parasites: Analysis of somatic extracts, in vitro secretions and infection sera from Brugia malayi and B. pahangi, Parasite Immunol. 9:49–66.

    Article  PubMed  CAS  Google Scholar 

  • Maizels, R. M., Kurniawan, A., Selkirk, M. E., and Yazdanbakhsh, M., 1991, Immune responses to filarial parasites, Immunol. Lett. 30:249–254.

    Article  PubMed  CAS  Google Scholar 

  • Mehta, K., Subrahmanyam, D., and Sindhu, R. K., 1981, Immunogenicity of homogenates of the developmental stages of Litomosoides carinii in albino rats, Acta Trop. 38:319–324.

    PubMed  CAS  Google Scholar 

  • Mejia, J. S., and Carlow, C. K., 1994, An analysis of the humoral immune response of dogs following vaccination with irradiated infective larvae of Dirofilaria immitis, Parasite Immunol. 16:157–164.

    Article  PubMed  CAS  Google Scholar 

  • Miller, T. A., 1964, Effect of X-irradiation upon the infective larvae of Ancylostoma caninum and the immunogenic effect in dogs of a single infection with 40 kr-irradiated larvae, J. Immunol. 50:735–742.

    CAS  Google Scholar 

  • Nanduri, J., and Kazura, J. W. 1989, Paramyosin-enhanced clearance of Brugia malayi microfilaremia inmice, J. Immunol. 143:3359–3363.

    PubMed  CAS  Google Scholar 

  • Neilsen, J. T. M., 1976, A comparison of the acquired resistance to Dipetalonema viteae stimulated in hamsters by trickle versus tertiary infections, Tropenmed. Parasitol. 27:233–237.

    Google Scholar 

  • Neva, F. A., and Ottesen, E. A., 1978, Tropical (filarial) eosinophilia, N. Engl J. Med. 298:1129–1131.

    Article  PubMed  CAS  Google Scholar 

  • Nilsen, T. W., Maroney, P. A., Goodwin, R. G., Perrine, K. G., Denker, J. A., Nanduri, J., and Kazura, J. W., 1988, Cloning and characterization of a potentially protective antigen in lymphatic filariasis, Proc. Natl Acad. Sci. USA 85:3604–3607.

    Article  PubMed  CAS  Google Scholar 

  • Nutman, T. B., 1989, Protective immunity in lymphatic filariasis, Exp. Parasitol. 68:248–252.

    Article  PubMed  CAS  Google Scholar 

  • Nutman, T. B., Kumaraswami, V., and Ottesen, E. A., 1987, Parasite-specific anergy in human filariasis. Insights after analysis of parasite antigen-driven lymphokine production, J. Clin. Invest. 79:1516–1523.

    Article  PubMed  CAS  Google Scholar 

  • Nutman, T. B., Steel, C., Ward, D. J., Zea-Flores, G., and Ottesen, E. A., 1991, Immunity to onchocerciasis: Recognition of larval antigens by humans putatively immune to Onchocerca volvulus infection, J. Infect. Dis. 163:1128–1133.

    Article  PubMed  CAS  Google Scholar 

  • Ogilvie, B. M., Philipp, M., Jungery, M., Maizels, R. M., and Parkhouse, R. M. E., 1980, The surface of nematodes and the immune response of the host, in: Host-Invader Interplay (H. Van Den Bossche, ed.), Elsevier/North-Holland, Amsterdam, pp. 99–104.

    Google Scholar 

  • Oothuman, P., Denham, D. A., McGreevy, P. B., andNelson, G. S., 1978, Studies with Brugia pahangi. 15. Cobalt 60 irradiation of the worm, J. Helminthol. 52:121–126.

    Article  PubMed  CAS  Google Scholar 

  • Oothuman, P., Denham, D. A., McGreevy, P. B., Nelson, G. S., and Rogers, R., 1979, Successful vaccination of cats against Brugia pahangi with larvae attenuated by irradiation with 10 krad cobalt 60, Parasite Immunol. 1:209–216.

    Article  PubMed  CAS  Google Scholar 

  • Ottesen, E. A., 1984, Immunological aspects of lymphatic filariasis and onchocerciasis in man, Trans. R. Soc. Trop. Med. Hyg. 78:9–18.

    Article  PubMed  Google Scholar 

  • Ottesen, E. A., 1992, Infection and disease in lymphatic filariasis: An immunological perspective, Parasitology 104:871–879.

    Article  Google Scholar 

  • Ottesen, E. A., Weiler, P. F., and Heck, L., 1977, Specific cellular immune unresponsiveness in human filariasis, Immunology 33:413–421.

    PubMed  CAS  Google Scholar 

  • Ottesen, E. A., Neva, F. A., Paranjape, R. S., Tripathy, S. P., Thiruvengadam, K. V., and Beaven, M. A., 1979, Specific allergic sensitization to filarial antigens in tropical eosinophilia syndrome, Lancet 1158-1161.

    Google Scholar 

  • Ottesen, E. A., Weiler, P. F., Lunde, M. N., and Hussain, R., 1982, Endemic filariasis on a Pacific island II. Immunologic aspects: Immunoglobulin, complement, and specific antifilarial IgG, IgM and IgE antibodies, Am. J. Trop. Med. Hyg. 31:953–961.

    PubMed  CAS  Google Scholar 

  • Otto, G. F., 1969, The immune phenomenon, J. Am. Vet. Med. Assoc. 154:386–387.

    PubMed  CAS  Google Scholar 

  • Owhashi, M., Futaki, S., Kitagawa, K., Horii, Y., Maruyama, H., Hayashi, H., and Nawa, Y., 1993, Molecular cloning and characterization of a novel neutrophil chemotactic factor from a filarial parasite, Mol. Immunol. 30:1315–1320.

    Article  PubMed  CAS  Google Scholar 

  • Pery, P., Petit, A., Poulain, J., and Luffan, G., 1974, Phosphorylcholine-bearing components in homogenates of nematodes, Eur. J. Immunol. 4:637–639.

    Article  PubMed  CAS  Google Scholar 

  • Philipp, M., Davis, T. B., Storey, N., and Carlow, C. K. S., 1988, Immunity in filariasis: Perspectives for vaccine development, Annu. Rev. Microbiol. 42:685–716.

    Article  PubMed  CAS  Google Scholar 

  • Piessens, W. F., and Mackenzie, C. D., 1982, Lymphatic filariasis and onchocerciasis, in: Immunology of Parasitic Infections, Vol. 2 (S. Cohen and K. S. Warren, eds.), Blackwell, Oxford, pp. 622–653.

    Google Scholar 

  • Piessens, W. F., McGreevy, P. B., Piessens, P. W., McGreevy, M., Koiman, I., Saroso, S., and Dennis, D. T., 1980a, Immune responses in human infections with Brugia malayi, J. Clin. Invest. 65: 172–179.

    Article  PubMed  CAS  Google Scholar 

  • Piessens, W. F., McGreevy, P. B., Ratiwayanto, S., McGreevy, M., Piessens, P., Koiman, I., Saroso, J., and Dennis, D. T., 1980b, Immune responses in human infections with Brugia malayi: Correlation of cellular and humoral reactions to microfilarial antigens with clinical status, Am. J. Trop. Med. Hyg. 29:563–670.

    PubMed  CAS  Google Scholar 

  • Pinder, M., Dupont, A., and Egwang, T., 1988, Identification of a surface antigen on Loa loa microfilariae the recognition of which correlates with the amicrofilaremic state in man, J. Immunol. 141:2480–2486.

    PubMed  CAS  Google Scholar 

  • Poole, C. B., Grandea, A. G., Maina, C. V., Jenkins, R. E., Selkirk, M., and McReynolds, L. A., 1992, Cloning of a cuticular antigen that contains multiple tandem repeats from the filarial parasite Dirofilaria immitis, Proc. Natl. Acad. Sci. USA 89:5986–5990.

    Article  PubMed  CAS  Google Scholar 

  • Raghavan, N., McReynolds, L., Maina, C., Feinstone, S., Jayarama, K., Ottesen, E., and Nutman, T., 1991, A recombinant clone of Wuchereria bancrofti with DNA specificity for human lymphatic filarial parasites, Mol. Biochem. Parasitol. 47:63–72.

    Article  PubMed  CAS  Google Scholar 

  • Raghavan, N., Maina, C., Fitzgerald, P., Tuan, R., Slatko, B., Ottesen, E., and Nutman, T., 1992, Characterization of a muscle-associated antigen from Wuchereria bancrofti, Exp. Parasitol. 75:379–389.

    Article  PubMed  CAS  Google Scholar 

  • Raghavan, N., Freedman, D. O., Fitzgerald, P. C., Unnasch, T. R., Ottesen, E. A., and Nutman, T. B., 1994, Cloning and characterization of a potentially protective chitinase-like recombinant antigen from Wuchereria bancrofti, Infect. Immun. 62:1901–1908.

    PubMed  CAS  Google Scholar 

  • Rajasekariah, G. R., Monteiro, YM., Nelto, A., Deshpande, L., and Subrahmanyam, D., 1989, Protective immune responses with trickle infections of the third stage filarial larvae, Wuchereria bancrofti in mice, Clin. Exp. Immunol. 78:292–298.

    PubMed  CAS  Google Scholar 

  • Rao, Y. V. B. G., Mehta, K., and Subrahmanyam, D., 1977, Litomosoides carinii: Effect of irradiation on the development and immunogenicity of the larval forms, Exp. Parasitol. 43:39–44.

    Article  Google Scholar 

  • Rener, J., Graves, P. M., Carter, R., Williams, J. L., and Burkot, T. R., 1983, Target antigens of transmission blocking immunity on gametes of Plasmodium falciparum, J. Exp. Med. 158:976–981.

    Article  PubMed  CAS  Google Scholar 

  • Rothstein, N., and Rajan, T. V., 1991, Characterization of an hsp70 gene from the human filarial parasite, Brugia malayi (Nematoda), Mol. Biochem. Parasitol. 49:229–238.

    Article  PubMed  CAS  Google Scholar 

  • Rothstein, N. M., Higashi, G., Yates, J., and Rajan, T. V., 1989, Onchocerca volvulus heat shock protein 70 is a major immunogen in amicrofilaremic individuals from a filariasis-endemic area, Mol. Biochem. Parasitol. 33:229–236.

    Article  PubMed  CAS  Google Scholar 

  • Scott, A. L., Dinman, J., Sussman, D., Yenbutr, P., and Ward, S., 1989, Major sperm protein genes from Onchocerca volvulus, Mol. Biochem. Parasitol. 36:119–126.

    Article  PubMed  CAS  Google Scholar 

  • Seeber, F., Brattig, N., Soboslay, P. T., Pogonka, T., Lorz, A., Strote, G., Beck, E., Titanji, V. P. K., and Lucius, R., 1993a, Characterization of a recombinant T cell and B cell reactive Polypeptide of Onchocerca volvulus, J. Immunol. 150: 2931–2944.

    PubMed  CAS  Google Scholar 

  • Seeber, F., Pogonka, T., and Lucius, R., 1993b, PCR mediated cDNA synthesis from minute amounts of filarial L3 RNA, Trop. Med. Parasitol. 44:57–59.

    PubMed  CAS  Google Scholar 

  • Selkirk, M. E., Denham, D. A., Partono, F., and Maizels, R. M., 1989, Heat shock cognate 70 is a prominent immunogen in brugian filariasis, J. Immunol. 143:299–308.

    PubMed  CAS  Google Scholar 

  • Selkirk, M. E., Yazdanbakhsh, M., Freedman, D., Blaxter, M. L., Cookson, E., Jenkins, R. E., and Williams, S. A., 1991, A proline-rich structural protein of the surface sheath of larval Brugia filarial nematode parasites, J. Biol. Chem. 266:11002–11008.

    PubMed  CAS  Google Scholar 

  • Selkirk, M. E., Maizels, R. M., and Yazdanbakhsh, M., 1992, Immunity and the prospects for vaccination against filariasis, Immunobiology 184:263–281.

    Article  PubMed  CAS  Google Scholar 

  • Smithers, S. R., and Terry, R. J., 1976, The immunology of Schistosomiasis, Adv. Parasitol. 14:399–422.

    Article  PubMed  CAS  Google Scholar 

  • Spence, H., Moore, J., Brass, A., and Kennedy, M., 1993, A cDNA encoding repeating units of the ABA-1 allergen of Ascaris, Mol. Biochem. Parasitol. 57:339–344.

    Article  PubMed  CAS  Google Scholar 

  • Steel, C., and Nutman, T., 1993, Regulation of IL-5 in onchocerciasis, J. Immunol. 150:5511–5518.

    PubMed  CAS  Google Scholar 

  • Storey, D. M., and Al-Mukhtar, A. S., 1982a, The development of normal and γ-irradiated Litomosoides carinii larvae in cotton rats, Tropenmed. Parasitol. 33:223–226.

    PubMed  CAS  Google Scholar 

  • Storey, D. M., and Al-Mukhtar, A. S., 1982b, Vaccination of jirds (Meriones unguiculatus) against Litomosoides carinii and Brugia pahangi using irradiated larvae of L. carinii, Tropenmed. Parasitol. 33:23–24.

    CAS  Google Scholar 

  • Subrahmanyam, D., Mehta, K., Nelson, D. S., Rao, Y. V., and Rao, C. K., 1978, Immune reactions in human Filariasis, J. Clin. Microbiol. 8:228–232.

    PubMed  CAS  Google Scholar 

  • Sun, S., Matsuura, T., and Sugane, K., 1991, Molecular cloning of the cDNA encoding an immunodominant antigen of Dirofilaria immitis, J. Helminthol. 65:149–158.

    Article  PubMed  CAS  Google Scholar 

  • Tang, L., Ou, X., Henkle-Duhrsen, K., and Selkirk, M., 1994, Extracellular and cytoplasmic CuZn Superoxide dismutases from Brugia lymphatic filarial nematode parasites, Infect. Immun. 62:961–967.

    PubMed  CAS  Google Scholar 

  • Tanner, M., and Weiss, N., 1981a, Dipetalonema viteae (Filarioidea): Development of the infective larvae in micropore chambers implanted into normal, infected and immunizedjirds, Trans. R. Soc. Trop. Med. Hyg. 75:173–174.

    Article  PubMed  CAS  Google Scholar 

  • Tanner, M., and Weiss, N., 1981b, Dipetalonema viteae (Filarioidea): Evidence for a serum-dependent cytotoxicity against developing third and fourth stage larvae in vitro, Acta Trop. 38:325–328.

    PubMed  CAS  Google Scholar 

  • Taylor, H. R., 1985, Research priorities for immunologic aspects of onchocerciasis, J. Infect. Dis. 152:389–394.

    Article  Google Scholar 

  • Taylor, M. J., van Es, R. P., Shay, K., Folkard, S., Townson, S., and Bianco, A., 1994, Protective immunity against Onchocerca volvulus and O. lienalis infective larvae in mice, Trop. Med. Parasitol. 45:17–23.

    PubMed  CAS  Google Scholar 

  • Townson, S., and Bianco, A. E., 1982, Immunization of calves against the microfilariae of Onchocerca lienalis, J. Helminthol. 56:297–303

    Article  PubMed  CAS  Google Scholar 

  • Townson, S., Bianco, A. E., Doenhoff, M. J., and Muller, R., 1984, Immunity to Onchocerca lienalis microfilariae in mice I. Resistance induced by the homologous parasite, Tropenmed. Parasitol. 35:202–208.

    PubMed  CAS  Google Scholar 

  • Tuan, R. S., Shepley, K. J., Mulligan, M. M., Abraham, D., and Perler, F. B., 1991, Histochemical localization of gene expression in Onchocerca volvulus: In situ DNA histohybridization and immunocytochemistry, Mol. Biochem. Parasitol. 49:191–204.

    Article  PubMed  CAS  Google Scholar 

  • Tweedie, S., Paxton, W., Ingram, L., Maizels, R., McReynolds, L., and Selkirk, M., 1993, Brugia pahangi and Brugia malayi: A surface-associated glycoprotein (gp 15/400) is composed of multiple tandemly repeated uriits and processed from a 400-kDa precursor, Exp. Parasitol. 76:156–164.

    Article  PubMed  CAS  Google Scholar 

  • Unnasch, T. R., Gallin, M. Y., Soboslay, P. T., Erttmann, K. D., and Greene, B. M., 1988, Isolation and characterization of expression cDNA clones encoding antigens of Onchocerca volvulus infective larvae, J. Clin. Invest. 82:262–269.

    Article  PubMed  CAS  Google Scholar 

  • Vanamail, P., Subramanian, S., Das, P. K., Pani, S. P., Rajagopalan, P. K., Bundy, D. A. P., and Grenfell, B. T., 1989, Estimation of age-specific rates of acquisition and loss of Wuchereria bancrofli infection, Trans. R. Soc. Trop. Med. Hyg. 83:689–693.

    Article  PubMed  CAS  Google Scholar 

  • Wakelin, D., 1984, Nematodes which invade tissues: The cuticle as target for effector mechanisms, in: Immunity to Parasites, Edward Arnold, London, pp. 117–133.

    Google Scholar 

  • Ward, D. J., Nutman, T. B., Zea-Flores, G., Portocarrero, C., Lujan, A., and Ottesen, E. A., 1988, Onchocerciasis and immunity in humans: Enhanced T cell responsiveness to parasite antigen in putatively immune individuals, J. Infect. Dis. 157:536–543.

    Article  PubMed  CAS  Google Scholar 

  • Weil, G. J., Powers, K. G., Parbuoni, B. R., Furrow, R. D., and Ottesen, E. A., 1982, Dirofilaria immitis: Antimicrofilarial immunity in experimental filariasis, Am. J. Trop. Med. Hyg. 31:477–483.

    PubMed  CAS  Google Scholar 

  • Weiner, D. J., Abraham, D., and D’Antonio, R., 1984, Litomosoides carinii in jirds (Meriones unguiculatus): Ability to retard development of challenge larvae can be transferred with cells and serum, J. Helminthol. 58:129–137.

    Article  PubMed  CAS  Google Scholar 

  • Weiss, N., and Tanner, M., 1979, Studies on Dipetalonema viteae (Filarioidea). 3. Antibody-dependent cell-mediated destruction of microfilariae in vivo, Tropenmed. Parasitol. 30:73–80.

    PubMed  CAS  Google Scholar 

  • Weiss, N., and Tanner, M., 1981, Immunogenicity of the surface of filarial larvae Dipetalonema viteae, Trans. R. Soc. Trop. Med. Hyg. 75:179–181.

    Article  PubMed  CAS  Google Scholar 

  • Werner, C., and Rajan, T. V., 1992, Comparison of the body wall myosin heavy chain sequences from Onchocerca volvulus and Brugia malayi, Mol. Biochem. Parasitol. 50:255–260.

    Article  PubMed  CAS  Google Scholar 

  • Werner, C., Higashi, G. I., Yates, J. A., and Rajan, T. V., 1989, Differential recognition of two cloned Brugia malayi antigens by antibody class, Mol. Biochem. Parasitol. 35:209–218.

    Article  PubMed  CAS  Google Scholar 

  • Wong, M. M., 1964, Studies on microfilaremia in dogs: Levels of microfilaremia in relation to immunologic responses of the host, Am. J. Trop. Med. Hyg. 14:66–77.

    Google Scholar 

  • Wong, M. M., and Guest, M. F., 1969, Filarial antibodies and eosinophilia in human subjects in an endemic area, Trans. R. Soc. Trop. Med. Hyg. 63:796–799.

    Article  PubMed  CAS  Google Scholar 

  • Wong, M. M., Fredericks, H. J., and Ramachandran, C. P., 1969, Studies on immunization against Brugia malayi infection in the rhesus monkey, Bull. WHO 40:493–501.

    PubMed  CAS  Google Scholar 

  • Wong, M. M., Guest, M. F., and Lavoipierre, M. J., 1974, Dirofilaria immitis: Fate and immunogenicity of irradiated infective stage larvae of beagles, Exp. Parasitol. 35:465–474.

    Article  PubMed  CAS  Google Scholar 

  • World Health Organization, 1987, Protective immunity and vaccination in onchocerciasis and lymphatic filariasis: Report of the 13th meeting of the scientific working group on filariasis, WHO Document TDR/FIL/SWG (13)/87.3, Geneva.

    Google Scholar 

  • World Health Organization Experts Committee, 1976, Epidemiology of onchocerciasis, WHO Tech. Rep. Ser. 597:1–94.

    Google Scholar 

  • Yates, J. A., and Higashi, G. I., 1985, Brugia malayi: Vaccination of jirds with 60cobalt-attenuated infective stage larvae protects against homologous challenge, Am. J. Trop. Med. Hyg. 34:1132–1137.

    PubMed  CAS  Google Scholar 

  • Zeng, W., and Donelson, J. E., 1992, The actin genes of Onchocerca volvulus, Mol. Biochem. Parasitol. 55:207–216.

    Article  PubMed  CAS  Google Scholar 

  • Zeng, W., Alarcon, C., and Donelson, J., 1990, Many transcribed regions of the Onchocerca volvulus genome contain the spliced leader of Caenorhabditis elegans, Mol. Cell. Biol. 10:2765–2773.

    PubMed  CAS  Google Scholar 

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  1. Paravax, Inc., Fort Collins, Colorado, 80525, USA

    Robert B. Grieve, Nancy Wisnewski, Glenn R. Frank & Cynthia A. Tripp

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    Michael F. Powell

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Grieve, R.B., Wisnewski, N., Frank, G.R., Tripp, C.A. (1995). Vaccine Research and Development for the Prevention of Filarial Nematode Infections. In: Powell, M.F., Newman, M.J. (eds) Vaccine Design. Pharmaceutical Biotechnology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1823-5_33

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