Abstract
The Start transition in the budding yeast cell cycle is the point of most physiological regulation of cell cycle commitment. This transition is controlled by the CLN1,2,3 gene family. We review what is known about the regulation, inter-regulation and function of these genes in controlling the Start transition.
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References
Pringle, J. R. and Hartwell, L. H. (1981) in The Molecular Biology of the Yeast Saccharomyces: life cycle and inheritance (Strathern, J. N., Jones, E. W., and Broach, J. R., Eds.), pp. 97–142, Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
Draetta, G. F. (1994) Curr. Opin. Cell Biol. 6, 842–846.
Elledge, S. J. and Harper, J. W. (1994) Curr. Opin. Cell Biol. 6, 847–852.
Reed, S. I. (1992) Annu. Rev. Cell Biol. 8, 529–561.
Feaver, W. J., Svejstrup, J. Q., Henry, N. L., and Kornberg, R. D. (1994) Cell 79, 1103–1109.
Hirst, K., Fisher, F., McAndrew, P. C., and Goding, C. R. (1994) EMBO J. 13, 5410–5420.
Kaffman, A., Herskowitz, I., Tjian, R., and O’Shea, E. K. (1994) Science 263, 1153–1156.
Roy, R., Adamczewski, J. P., Seroz, T., Vermeulen, W., Tassan, J., Schaeffer, L., Nigg, E. A., Hoeijmakers, J. H. J., and Egly, J. (1994) Cell 79, 1093–1101.
Lorincz, A. T. and Reed, S. I. (1984) Nature 307, 183–185.
Beach, D., Durkacz, B., and Nurse, P. (1982) Nature 300, 706–709.
Nasmyth, K. (1993) Curr. Opin. Cell Biol. 5, 166–179.
Sudbery, P. E., Goodey, A. R., and Carter, B. L. (1980) Nature 288, 401–404.
Nash, R., Tokiwa, G., Anand, S., Erickson, K., and Futcher, A. B. (1988) EMBO. J. 7, 4335–4346.
Cross, F. R. (1988) Mol. Cell Biol. 8, 4675–4684.
Cross, F. R. and Tinkelenberg, A. H. (1991) Cell 65, 875–883.
Cross, F. R. (1992) Cold. Spring. Harb. Symp. Quant. Biol. LVI, 1–8.
Hadwiger, J. A., Wittenberg, C., Richardson, H. E., De Barros Lopes, M., and Reed, S. I. (1989) Proc. Natl. Acad. Sci. USA 86, 6255–6259.
Jarvik, J. and Botstein, D. (1975) Proc. Natl. Acad. Sci USA 72, 2738–2742.
Richardson, H. E., Wittenberg, C., Cross, F., and Reed, S. I. (1989) Cell 59, 1127–1133.
Cross, F. R. (1990) Mol. Cell. Biol. 10, 6482–6490.
Tyers, M., Tokiwa, G., Nash, R., and Futcher, B. (1992) EMBO J. 11, 1773–1784.
Oehlen, L. J. W. M. and Cross, F. R. (1994) Genes Dev. 8, 1058–1070.
McKinney, J.D. and Cross, F. R. (1995) Mol. Cell. Biol. 15, 2509–2516.
Wittenberg, C., Sugimoto, K., and Reed, S. I. (1990) Cell 62, 225–237.
Tyers, M., Tokiwa, G., and Futcher, B. (1993) EMBO J. 12, 1955–1968.
Rogers, S., Wells, R., and Rechsteiner, M. (1986) Science 234, 364–368.
Salama, S. R., Hendricks, K. B., and Thorner, J. (1994) Mol. Cell. Biol. 14, 7953–7966.
Cross, F. R. and Blake, C. M. (1993) Mol. Cell. Biol. 13, 3266–3271.
Yaglom, J., Linskens, M. H. K., Sadis, S., Rubin, D. M., Futcher, B., and Finley, D. (1995) Molecular and Cellular Biology 15, 731–740.
Deshaies, R.J., V. Chau, and Kirschner, M. (1995) EMBO. J. 14, 303–312.
Hirsch, J. P. and Cross, F. R. (1992) BioEssays 14, 367–373.
Dirick, L. and Nasmyth, K. (1991) Nature 351, 754–757.
Nasmyth, K. (1983) Nature 302, 670–676.
Haber, J. E. and Garvik, B. (1977) Genetics 87, 33–50.
Stern, M., Jensen, R., and Herskowitz, I. (1984) Journal of Molecular Biology 178, 853–868.
Breeden, L. and Nasmyth, K. (1987) Cell 48, 389–397.
Nasmyth, K. (1985) Cell 42, 225–235.
Andrews, B. J. and Herskowitz, I. (1989) Nature 342, 830–833.
Primig, M., Sockanathan, S., Auer, H., and Nasmyth, K. (1992) Nature 358, 593–597.
Koch, C., Moll, T., Neuberg, M., Ahorn, H., and Nasmyth, K. (1993) Science 261, 1551–1557.
Nasmyth, K. and Dirick, L. (1991) Cell 66, 995–1013.
Ogas, J., Andrews, B. J., and Herskowitz, I. (1991) Cell 66, 1015–1026.
Cross, F. R., Hoek, M., McKinney, J. D., and Tinkelenberg, A. H. (1994) Mol. Cell Biol. 14, 4779–4787.
Benton, B. K., Tinkelenberg, A. H., Jean, D., Plump, S. D., and Cross, F. R. (1993) EMBO J. 12, 5267–5275.
Cvrckova, F. and Nasmyth, K. (1993) EMBO J. 12, 5277–5286.
Stuart, D. and Wittenberg, C. (1994) Mol. Cell. Biol. 14, 4788–4801.
Dirick, L., Moll, T., Auer, H., and Nasmyth, K. (1992) Nature 357, 508–513.
Lowndes, N. F., Johnson, A. L., Breeden, L., and Johnston, L. H. (1992) Nature 357, 505–513.
Johnston, L. H. and Lowndes, N. F. (1992) Nucleic Acids Res. 20, 2403–2410.
Epstein, C. B. and Cross, F. R. (1992) Genes Dev. 6, 1695–1706.
Schwob, E. and Nasmyth, K. (1993) Genes Dev. 7, 1160–1175.
Espinoza, F. H., Ogas, J., Herskowitz, I., and Morgan, D. O. (1994) Science 266, 1388–1391.
Measday, V., Moore, L., Ogas, J., Tyers, M., and Andrews, B. (1994) Science 266, 1391–1395.
Epstein, C. B. and Cross, F. R. (1994) Mol. Cell. Biol. 14, 2041–2047.
Lee, K. S., Hines, L. K., and Levin, D. E. (1993) Mol. Cell. Biol. 13, 5843–5853.
Arndt, K. T., Styles, C. A., and Fink, G. R. (1989) Cell 56, 527–537.
Sutton, A., Immanuel, D., and Arndt, K. T. (1991) Mol. Cell. Biol. 11, 2133–2148.
Fernandez-Sarabia, M. J., Sutton, A., Zhong, T., and Arndt, K. T. (1992) Genes Dev. 6, 2417–2428.
Di Como, C. J., Bose, R., and Arndt, K. T. (1995) Genetics 139, 95–107.
Rowley, A., Singer, R. A., and Johnston, G. C. (1991) Mol. Cell. Biol. 11, 5718–5726.
Drebot, M. A., Johnston, G. C., Friesen, J. D., and Singer, R. A. (1993) Mol. Gen. Genet. 241, 327–334.
Lycan, D., Mikesell, G., Bunger, M., and Breeden, L. (1994) Mol. Cell. Biol. 14, 7455–7465.
Ko, H. A. and Moore, S. A. (1990) J. Biol. Chem. 265, 21652–21663.
Amon, A., Tyers, M., Futcher, B., and Nasmyth, K. (1993) Cell 74, 993–1007.
Surana, U., Robitsch, H., Price, C., Schuster, T., Fitch, I., Futcher, A. B., and Nasmyth, K. (1991) Cell 65, 145–161.
Richardson, H., Lew, D. J., Henze, M., Sugimoto, K., and Reed, S. I. (1992) Genes Dev. 6, 2021–2034.
Surana, U., Amon, A., Dowzer, C., McGrew, J., Byers, B., and Nasmyth, K. (1993) EMBO J. 12, 1969–1978.
Amon, A., Irniger, S., and Nasmyth, K. (1994) Cell 77, 1037–1050.
Glotzer, M., Murray, A. W., and Kirschner, M. W. (1991) Nature 349, 132–138.
Seufert, W., Futcher, B., and Jentsch, S. (1995) Nature 373, 78–81.
Donovan, J. D., Toyn, J. H., Johnson, A. L., and Johnston, L. H. (1994) Genes Dev. 8, 1640–1653.
Nugroho, T. T. and Mendenhall, M. D. (1994) Mol. Cell. Biol. 14, 3320–3328.
Schwob, E., Böhm, T., Mendenhall, M. D., and Nasmyth, K. (1994) Cell 79, 233–244.
Reed, S. I., Hadwiger, J. A., and L:orincz, A. T. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4055–4059.
Mendenhall, M. D. (1993) Science 259, 216–219.
Lew, D. J. and Reed, S. I. (1993) J. Cell Biol. 120, 1305–1320.
Ghiara, J. B., Richardson, H. E., Sugimoto, K., Henze, M., Lew, D. J., Wittenberg, C., and Reed, S. I. (1991) Cell 65, 163–174.
Kühne, C. and Linder, P. (1993) EMBO J. 12, 3437–3447.
Frohlich, K. U., Fries, H. W., Rudiger, M., Erdmann, R., Botstein, D., and Mecke, D. (1991) J. Cell Biol. 114, 443–453.
Toh-e, A., Tanaka, K., Uesono, Y., and Wickner, R. B. (1988) Mol. Gen. Genet. 214, 162–164.
Sloat, B. F., Adams, A., and Pringle, J. R. (1981) J. Cell Biol. 89, 395–405.
Adams, A. E. M., Johnson, D. I., Longnecker, R. M., Sloat, B. F., and Pringle, J. R. (1990) J. Cell Biol. 111, 131–142.
Bender, A. and Pringle, J. R. (1991) Mol. Cell. Biol. 11, 1295–1305.
Park, H., Chant, I., and Herskowitz, I. (1993) Nature 365, 269–274.
Chant, J. and Herskowitz, I. (1991) Cell 65, 1203–1212.
Bourne, H. R., Sanders, D. A., and McCormick, F. (1991) Nature 349, 117–126.
Valien, E.A., Cross, R.R. (1995) Mol. Cell. Biol. 15, 4291–4302.
Reagan, M.S., Pttengr, C., Siede, W., Friedberg, E.C. (1995) J. Bacterial 177, 364–371.
Carr, A. M., Sheldrick, K. S., Murray, J. M., Al-Harithy, R., Watts, F. Z., and Lehmann, A. R. (1993) Nucleic Acids Res. 21, 1345–1349.
Harrington, J. J. and Lieber, M. R. (1994) Genes & Development 8, 1344–1355.
Weinert, T. A. and Hartwell, L. H. (1988) Science 241, 317–322.
Peter, M. and Herskowitz, I. (1994) Science 265, 1228–1231.
Sprague, G. F.,Jr. and Thorner, J. W.(1992) in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression (Jones, E. W., Pringle, J. R., and Broach, J. R., Eds.), pp. 657–744, Cold Spring Harbor Laboratory, Cold Spring Harbor.
Tyers, M. and Futcher, B. (1993) Mol. Cell. Biol. 13, 5659–5669.
Chang, F. and Herskowitz, I. (1990) Cell 63, 999–1011.
Peter, M., Gartner, A., Horecka, J., Ammerer, G., and Herskowitz, I. (1993) Cell 73, 747–760.
Chang, F. and Herskowitz, I. (1992) Mol. Biol. Cell 3, 445–450.
Elion, E. A., Grisafi, P. L., and Fink, G. R. (1990) Cell 60, 649–664.
Valdivieso, M. H., Sugimoto, K., Jahng, K.-Y., Fernandes, P. M. B., and Wittenberg, C. (1993) Mol. Cell. Biol. 13, 1013–1022.
Reid, B. J. and Hartwell, L. H. (1977) J. Cell Biol. 75, 355–365.
McKinney, J. D., Chang, F., Heintz, N., and Cross, F. R. (1993) Genes Dev. 7, 833–843.
Zanolari, B. and Riezman, H. (1991) Mol. Cell. Biol. 11, 5251–5258.
Trueheart, J., Boeke, J. D., and Fink, G. R. (1987) Mol. Cell. Biol. 7, 2316–2328.
Baroni, M. D., Monti, P., Marconi, G., and Alberghina, L. (1992) Experimental Cell Research 201, 299–306.
Baroni, M. D., Monti, P., and Alberghina, L. (1994) Nature 371, 339–342.
Tokiwa, G., Tyers, M., Volpe, T., and Futcher, B. (1994) Nature 371, 342–345.
Johnston, G. C., Pringle, J. R., and Hartwell, L. H. (1977) Exp. Cell Res. 105, 79–98.
Johnston, G. C., Ehrhardt, C. W., Lorincz, A., and Carter, B. L. (1979) J. Bacteriol 137, 1–5.
Lorincz, A. and Carter, B. L. A. (1979) J.GenMicrobiol. 113, 287–295.
Popolo, L., Vanoni, M., and Alberghina, L. (1982) Experimental Cell Research 142, 69–78.
Moore, S. A. (1988) J. Biol. Chem. 263, 9674–9681.
Veinot-Drebot, L. M., Johnston, G. C., and Singer, R. A. (1991) Curr. Genet. 19, 15–19.
Hubler, L., Bradshaw-Rouse, J., and Heideman, W. (1993) Mol. Cell. Biol. 13, 6274–6282.
Rowley, A., Johnston, G. C., Butler, B., Werner-Washburne, M., and Singer, R. A. (1993) Molecular and Cellular Biology 13, 1034–1041.
Lindquist, S. (1986) Annu. Rev. Biochem. 55, 1151–1191.
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Levine, K., Tinkelenberg, A.H., Cross, F. (1995). The CLN gene family: Central regulators of cell cycle Start in budding yeast. In: Meijer, L., Guidet, S., Tung, H.Y.L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1809-9_8
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DOI: https://doi.org/10.1007/978-1-4615-1809-9_8
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