Skip to main content
SpringerLink
Log in

Mechanism of action of rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells

  • Chapter
Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

The immunosuppressant drug, rapamycin (RAP), is a potent inhibitor of IL-2-dependent T-cell proliferation. The antiproliferative effect of RAP is mediated through the formation of an active complex with its cytosolic receptor protein, FKBP12. The molecular target of the FKBP12-RAP complex is a putative lipid kinase termed the mammalian Target Of Rapamycin (mTOR). This review will discuss recent findings suggesting that mTOR is a novel regulator of G1 to S-phase progression in eukaryotic cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Vezina, C., Kudelski, A. and Sehgal, S. (1975) J. Antibiot. 28, 721–726.

    PubMed  CAS  Google Scholar 

  2. Sehgal, S., Baker, H. and Vezina, C. (1975) J. Antibiot 28, 727–732.

    PubMed  CAS  Google Scholar 

  3. Baker, H., Sidorowicz, A., Sehgal, S. and Vezina, C. (1978) J. Antibiot 31, 539–545.

    PubMed  CAS  Google Scholar 

  4. Findlay, J. and Radics, L. (1980) Can. J. Chem. 58, 579–590.

    CAS  Google Scholar 

  5. Tanaka, H., Kuroda, A., Marusawa, H., Hatanaka, H., Kino, T., Goto, T., Hashimoto, M. and Taga, T. (1987) J. Am. Chem. Soc. 109, 5031–5033.

    CAS  Google Scholar 

  6. Dumont, F., Staruch, M., Koprak, S., Melino, M. and Sigal, N. (1990) J. Immunol. 144, 251–258.

    PubMed  CAS  Google Scholar 

  7. Siekierka, J., Hung, S., Poe, M., Lin, C. and Sigal, N. (1989) Nature 341, 755–757.

    PubMed  CAS  Google Scholar 

  8. Harding, M., Galat, A., Uehling, D. and Schreiber, S. (1989) Nature 341, 758–760.

    PubMed  CAS  Google Scholar 

  9. Sehgal, S. (1993) Ann. New York Acad. Sci. 696, 1–8.

    CAS  Google Scholar 

  10. Morris, R. (1992) Transplant Rev. 6, 39–87.

    Google Scholar 

  11. Schwartz, R. (1990) Science 248, 1349–1356.

    PubMed  CAS  Google Scholar 

  12. Rao, A. (1991) Critical Reviews in Immunology 10, 495–519.

    PubMed  CAS  Google Scholar 

  13. Janeway, C. and Bottomly, K. (1994) Cell 76, 275–285.

    PubMed  CAS  Google Scholar 

  14. Chan, A., Desai, D. and Weiss, A. (1994) Annu. Rev. Immunol. 12, 555–592.

    PubMed  CAS  Google Scholar 

  15. Weiss, A. and Littman, D. (1994) Cell 76, 263–274.

    PubMed  CAS  Google Scholar 

  16. Sigal, N. and Dumont, F. (1992) Annu. Rev. Immunol. 10, 519–560.

    PubMed  CAS  Google Scholar 

  17. O’Keefe, S., Tamura, J., Kincaid, R., Tocci, M. and O’Neill, E. (1992) Nature 357, 692–694.

    CAS  Google Scholar 

  18. Clipstone, N. and Crabtree, G. (1992) Nature 357, 695–697.

    PubMed  CAS  Google Scholar 

  19. Ullman, K., Northrop, J., Verweij, C. and Crabtree, G. (1990) Annu. Rev. Immunol. 8, 421–452.

    PubMed  CAS  Google Scholar 

  20. Frantz, B., Nordby, E., Bren, G., Steffan, N., Paya, C., Kincaid, R., Tocci, M., O’Keefe, S. and O’Neill, E. (1994) EMBO J. 13, 861–870.

    PubMed  CAS  Google Scholar 

  21. Rao, A. (1994) Immunology Today 15, 274–281.

    PubMed  CAS  Google Scholar 

  22. Cantrell, D. and Smith, K. (1984) Science 224, 1312–1316.

    PubMed  CAS  Google Scholar 

  23. Minami, Y., Kono, T., Miyazaki, T. and Taniguchi, T. (1993) Annu. Rev. Immunol. 11, 245–267.

    PubMed  CAS  Google Scholar 

  24. Nakamura, M., Asao, H., Takeshita, T. and Sugamura, K. (1993) Sem. Immunol. 5, 309–317.

    CAS  Google Scholar 

  25. Miyajima, A., Kitamura, T., Harada, N., Yokota, T. and Arai, K. (1992) Annu. Rev. Immunol. 10, 295–331.

    PubMed  CAS  Google Scholar 

  26. Kondo, M., Takeshita, T., Ishii, N., Nakamura, M., Watanabe, S., Arai, K. and Sugamura, K. (1993) Science 262, 1874–1877.

    PubMed  CAS  Google Scholar 

  27. Noguchi, M., Nakamura, Y., Russell, S., Ziegler, S., Tsang, M., Cao, X. and Leonard, W. (1993) Science 262, 1877–1880.

    PubMed  CAS  Google Scholar 

  28. Russell, S., Keegan, S., Harada, N., Nakamura, Y., Noguchi, M., Leland, P., Friedmann, M., Miyajima, A., Puri, R., Paul, W. and Leonard, W. (1993) Science 262, 1880–1883.

    PubMed  CAS  Google Scholar 

  29. Giri, J., Ahdieh, M., Eisenman, J., Shanebeck, K., Grabstein, K., Kumaki, S., Namen, A., Park, L., Cosman, D. and Anderson, D. (1994) EMBO J. 13, 2822–2830.

    PubMed  CAS  Google Scholar 

  30. Russell, S., Johnston, J., Noguchi, M., Kawamura, M., Bacon, S., Friedmann, M., Berg, M., McVicar, D., Witthuhn, B., Silvennoinen, O., Goldman, A., Schmalstieg, F., Ihle, J., O’Shea, J. and Leonard, W. (1994) Science 266, 1042–1045.

    PubMed  CAS  Google Scholar 

  31. Miyazaki, T., Kawahara, A., Fujii, H., Nakagawa, Y., Minami, Y., Liu, Z.-J., Oishi, I., Silvennoinen, O., Witthuhn, B., Ihle, J. and Taniguchi, T. (1994) Science 266, 1045–1047.

    PubMed  CAS  Google Scholar 

  32. Beadling, C., Guschin, D., Witthuhn, B., Ziemiecki, A., Ihle, J., Kerr, I. and Cantrell, D. (1994) EMBO J. 13, 5605–5615.

    PubMed  CAS  Google Scholar 

  33. Hatakeyama, M., Kono, T., Kobayashi, N., Kawahara, A., Levin, S., Perlmutter, R. and Taniguchi, T. (1991) Science 252, 1523–1528.

    PubMed  CAS  Google Scholar 

  34. Kobahashi, N., Kono, T., Hatakeyama, M., Minami, Y., Miyazaki, T., Perlmutter, R. and Taniguchi, T. (1993) Proc. Natl. Acad. Sci. USA 90, 4102–4105.

    Google Scholar 

  35. Karnitz, L. and Abraham, R. (in press) Curr. Opin. Immunol.

    Google Scholar 

  36. Sherr, C. (1993) Cell 73, 1059–1065.

    PubMed  CAS  Google Scholar 

  37. Matsushime, H., Roussel, M., Ashmun, R. and Sherr, C. (1991) Cell 65, 701–713.

    PubMed  CAS  Google Scholar 

  38. Ajchenbaum, F., Ando, K., DeCaprio, J. and Griffin, J. (1993) J. Biol. Chem. 268, 4113–4119.

    PubMed  CAS  Google Scholar 

  39. Morice, W., Wiederrecht, G., Brunn, G., Siekierka, J. and Abraham, R. (1993) J. Biol. Chem. 268, 22737–22745.

    PubMed  CAS  Google Scholar 

  40. Ohtsubo, M. and Roberts, J. (1993) Science 259, 1908–1912.

    PubMed  CAS  Google Scholar 

  41. Quelle, D., Ashmun, R., Shurtleff, S., Kato, J.-Y., Bar-Sagi, D., Roussel, M. and Sherr, C. (1993) Genes and Develop. 7, 1559–1571.

    CAS  Google Scholar 

  42. Resnitzky, D., Gossen, M., Bujard, H. and Reed, S. (1994) Mol. Cell. Biol. 14, 1669–1679.

    PubMed  CAS  Google Scholar 

  43. Tepper, M. (1993) Ann. New York Acad. Sci. 696, 123–132.

    CAS  Google Scholar 

  44. Group, O.M.T.S. (1985) N. Engl. J. Med. 313, 337–342.

    Google Scholar 

  45. Browne, B. and Kahan, B. (1994) Perspectives in Drug Discovery and Design 2, 31–48.

    Google Scholar 

  46. Linsley, P., Wallace, P., Johnson, J., Gibson, M., Greene, J., Ledbetter, J., Singh, C. and Tepper, M. (1992) Science 257, 792–795.

    PubMed  CAS  Google Scholar 

  47. Snyder, D. and Unanue, E. (1982) J. Immunol. 129, 1803–1805.

    PubMed  CAS  Google Scholar 

  48. Lee, S., Tson, A., Chou, H., Thomas, J., Petrie, K., Eugui, E. and Allison, A. (1988) Proc. Natl. Acad. Sci. USA 85, 1204–1208.

    PubMed  CAS  Google Scholar 

  49. Amano, Y., Lee, S. and Allison, A. (1993) Mol. Pharmacol 43, 176–182.

    PubMed  CAS  Google Scholar 

  50. Wu, J. (1994) Perspectives in Drug Discovery and Design 2, 185–294.

    CAS  Google Scholar 

  51. Borel, J., Feurer, C., Gubler, H. and Stahelin, H. (1976) Agents Action 6, 468–475.

    CAS  Google Scholar 

  52. Ellis, C., Fradin, M., Messana, J., Brawn, M., Siegel, M., Hartley, A., Rocher, L., Wheeler, S., Hamilton, T., Parish, T., Ellismadu, M., Duell, E., Annesley, T., Cooper, K. and Voorhees, J. (1991) N. Engl. J. Med. 324, 277–284.

    PubMed  CAS  Google Scholar 

  53. Bougneres, P., Landais, P., Boisson, C., Carel, J., Frament, N., Boitard, C., Chaussain, J. and Bach, J. (1990) Diabetes 39, 1264–1271.

    PubMed  CAS  Google Scholar 

  54. Masuda, K., Urayama, A., Klogure, M., Nakajima, A., Nakae, K. and Inaba, G. (1989) Lancet 1, 1093–1095.

    PubMed  CAS  Google Scholar 

  55. Kahan, B. (1989) N. England J. Med. 321, 1725–1738.

    CAS  Google Scholar 

  56. Kino, R., Hatanaka, H., Hashimoto, M., Nishiyama, M., Goto, T., Okuhara, M., Kohsaka, M., Aoki, H. and Imanaka, H. (1987) J. Antibiot. (Tokyo) 40, 1249–1255.

    CAS  Google Scholar 

  57. Kino, T., Hatanake, H., Miyata, S., Inamura, N., Nishiyama, M., Yajima, T., Goto, T., Okuhara, M., Kohsaka, M., Aoki, H. and Ochai, T. (1987) J. Antibiot. (Tokyo) 40, 1256–1265.

    CAS  Google Scholar 

  58. Tocci, M., Matkovich, D., Collier, K., Kwok, P., Dumont, F., Lin, S., Degudicibus, S., Siekierka, J., Chin, J. and Hutchinson, N. (1989) J. Immunol. 143, 718–726.

    PubMed  CAS  Google Scholar 

  59. Zipfel, P., Irving, S., Kelley, K. and Siebenlist, U. (1989) Mol. Cell. Biol. 9, 1041–1048.

    PubMed  CAS  Google Scholar 

  60. Hand Schumacher, R., Harding, M., Rice, J., Druggs, R. and Speicher, D. (1984) Science 226, 544–547.

    CAS  Google Scholar 

  61. Takahashi, N., Hayano, R. and Suzuki, M. (1989) Nature 337, 473–475.

    PubMed  CAS  Google Scholar 

  62. Fischer, G., Wittmann, L., Lang, K., Kiefhaber, T. and Schmid, F. (1989) Nature 337, 476–478.

    PubMed  CAS  Google Scholar 

  63. Siekierka, J., Wiederrecht, G., Greulich, H., Boulton, D., Hung, H., Cryan, J., Hodges, P. and Sigal, N. (1990) J. Biol. Chem. 265, 21011–21015.

    PubMed  CAS  Google Scholar 

  64. Dumont, F., Staruch, M., Koprak, S., Siekierka, J., Lin, C., Harrison, R., Sewell, T., Kindt, V., Beattie, T., Wyvratt, M. and Sigal, N. (1992) J. Exp. Med. 176, 751–760.

    PubMed  CAS  Google Scholar 

  65. Schreiber, S. (1991) Science 251, 283–287.

    PubMed  CAS  Google Scholar 

  66. Haendler, B., Keller, R., Hiestand, P., Kocher, H., Wegmann, G. and Movva, N. (1989) Gene 83, 39–46.

    PubMed  CAS  Google Scholar 

  67. Wiederrecht, G., Brizuela, L., Elliston, K., Sigal, N. and Siekierka, J. (1991) Proc. Natl. Acad. Sci. USA 88, 1029–1033.

    PubMed  CAS  Google Scholar 

  68. Heitman, J., Movva, N., Hiestand, P. and Hall, M. (1991) Proc. Natl. Acad. Sci. USA 88, 1948–1952.

    PubMed  CAS  Google Scholar 

  69. Koltin, Y., Faucette, L., Bergsma, D., Levy, M., Cafferkey, R., Koser, P., Johnson, R. and Livi, G. (1991) Mol. Cell. Biol. 11, 1718–1723.

    PubMed  CAS  Google Scholar 

  70. Friedman, J. and Weissman, I. (1991) Cell 66, 799–806.

    PubMed  CAS  Google Scholar 

  71. Liu, J., Farmer, J., Lane, W., Friedman, J., Weissman, I. and Schreiber, S. (1991) Cell 66, 807–815.

    PubMed  CAS  Google Scholar 

  72. Fliri, H., Baumann, G., Enz, A., Kallen, J., Luyten, M., Mikol, V., Movva, R., Quesniaux, V., Schreier, M., Walkinshaw, M., Wenger, R., Zenke, G. and Zurini, M. (1993) Ann. New York Acad. Sci. 696, 47–53.

    CAS  Google Scholar 

  73. Aperia, A., Ibarra, F., Svensson, L.-B., Klee, C. and Greengard, P. (1992) Proc. Natl. Acad. Sci. USA 89, 7394–7397.

    PubMed  CAS  Google Scholar 

  74. Dawson, T., Steiner, J., Dawson, V., Dinerman, J., Uhl, G. and Snyder, S. (1993) Proc. Natl. Acad. Sci. USA 90, 9808–9812.

    PubMed  CAS  Google Scholar 

  75. Galat, A. (1993) European Journal of Biochemistry 216, 689–707.

    PubMed  CAS  Google Scholar 

  76. Wiederrecht, G. and Etzkorn, F. (1994) Perspectives in Drug Discovery and Design 2, 57–84.

    CAS  Google Scholar 

  77. Sewell, T., Lam, E., Martin, M., Leszyk, J., Weidner, J., Calaycay, J., Griffin, P., Williams, H., Hung, S., Cryan, J., Sigal, N. and Wiederrecht, G. (1994) J. Biol. Chem. 269, 21094–21102.

    PubMed  CAS  Google Scholar 

  78. Arakawa, H., Nagase, H., Hayashi, N., Fujiwara, T., Ogawa, M., Shin, S. and Nakamura, Y. (1994) Biochem. Biophys. Res. Comm. 200, 836–843.

    PubMed  CAS  Google Scholar 

  79. Lebeau, M.-C., Myagkikh, I., Rouviere-Fourmy, N., Baulieu, E. and Klee, C. (1994) Biochem. Biophys. Res. Comm. 203, 750–755.

    PubMed  CAS  Google Scholar 

  80. Bram, R., Hung, D., Martin, P., Schreiber, S. and Crabtree, G. (1993) Molecular and Cellular Biology 13, 4760–4769.

    PubMed  CAS  Google Scholar 

  81. Martel, R., Klicius, J. and Galet, S. (1977) Can. J. Physiol. 55, 48–51.

    CAS  Google Scholar 

  82. Dumont, F., Melino, M., Staruch, M., Koprak, S., Fischer, P. and Sigal, N. (1990) J. Immunol. 144, 1418–1424.

    PubMed  CAS  Google Scholar 

  83. Altmeyer, A. and Dumont, F. (1993) Cytokine 5, 133–143.

    PubMed  CAS  Google Scholar 

  84. Wood, M. and Bierer, B. (1994) Perspectives in Drug Discovery and Design 2, 163–184.

    CAS  Google Scholar 

  85. Bierer, B., Mattila, P., Standaert, R., Herzenberg, L., Burakoff, S., Crabtree, G. and Schreiber, S. (1990) Proc. Natl. Acad. Sci. USA 87, 9231–9235.

    PubMed  CAS  Google Scholar 

  86. Heitman, J., Movva, N. and Hall, M. (1991) Science 253, 905–909.

    PubMed  CAS  Google Scholar 

  87. Brizuela, L., Chrebet, G., Bostian, K. and Parent, S. (1991) Mol. Cell. Biol. 11, 4616–4626.

    PubMed  CAS  Google Scholar 

  88. Foor, F., Parent, S., Morin, N., Dahl, A., Ramadan, N., Chrebet, G., Bostian, K. and Nielsen, J. (1992) Nature 360, 682–684.

    PubMed  CAS  Google Scholar 

  89. Kunz, J., Henriquez, R., Schneider, U., Deuter-Reinhard, M., Rao Movva, N. and Hall, M. (1993) Cell 73, 585–596.

    PubMed  CAS  Google Scholar 

  90. Cafferkey, R., Young, P., McLaughlin, M., Bergsma, D., Koltin, Y., Sathe, G., Faucette, L., Eng, W.-K., Johnson, R. and Livi, G. (1993) Mol. Cell. Biol. 13, 6012–6023.

    PubMed  CAS  Google Scholar 

  91. Helliwell, S., Wagner, P., Kunz, J., Deuter-Reinhard, M., Henriquez, R. and Hall, M. (1994) Mol. Biol. Cell 5, 105–118.

    PubMed  CAS  Google Scholar 

  92. Cafferkey, R., McLaughlin, M., Young, P., Johnson, R. and Livi, G. (1994) Gene 141, 133–136.

    PubMed  CAS  Google Scholar 

  93. Schu, P., Takegawa, K., Fry, M., Stack, J., Waterfield, M. and Emr, S. (1993) Science 260, 88–91.

    PubMed  CAS  Google Scholar 

  94. Stan, R., McLaughlin, M., Cafferkey, R., Johnson, R., Rosenberg, M. and Livi, G. (1994) J. Biol. Chem. 269, 32027–32030.

    PubMed  CAS  Google Scholar 

  95. Barbet, N., Schneider, U., Helliwell, S., Stansfield, I., Tuite, M. and Hall, M. (1995) EMBO J. submitted

    Google Scholar 

  96. Brenner, C., Nakayama, N., Goebl, M., Tanaka, K., Toh-e, A. and Matsumoto, K. (1988) Mol. Cell. Biol. 8, 3556–3559.

    PubMed  CAS  Google Scholar 

  97. Hartwell, L. and Unger, M. (1977) J. Cell Biol. 75, 422–435.

    PubMed  CAS  Google Scholar 

  98. Chung, J., Kuo, C., Crabtree, G. and Blenis, J. (1992) Cell 69, 1227–1236.

    PubMed  CAS  Google Scholar 

  99. Calvo, V., Crews, C., Vik, T. and Bierer, B. (1992) Proc. Natl. Acad. Sci. USA 89, 7571–7575.

    PubMed  CAS  Google Scholar 

  100. Thomas, G. (1993) Biochem. Soc. Trans. 21, 901–904.

    PubMed  CAS  Google Scholar 

  101. Kuo, C., Chung, J., Fiorentino, D., Flanagan, W., Blenis, J. and Crabtree, G. (1992) Nature 358, 70–73.

    PubMed  CAS  Google Scholar 

  102. Price, D., Grove, J., Calvo, V., Avruch, J. and Bierer, B. (1992) Science 257, 973–977.

    PubMed  CAS  Google Scholar 

  103. Ferrari, S., Bannwarth, W., Morley, S., Totty, N. and Thomas, G. (1992) Proc. Natl. Acad. Sci. USA 89, 7282–7286.

    PubMed  CAS  Google Scholar 

  104. Ferrari, S., Pearson, R., Siegmann, M., Kozma, S. and Thomas, G. (1993) J. Biol. Chem. 268, 16091–16094.

    PubMed  CAS  Google Scholar 

  105. Ming, X.-F., Burgering, B., Wennstrom, S., Claesson-Welsh, L., Heldin, G-H., Bos, J., Kozma, S. and Thomas, G. (1994) Nature 371, 426–429.

    PubMed  CAS  Google Scholar 

  106. Ballou, L., Luther, H. and Thomas, G. (1991) Nature 349, 348–350.

    PubMed  CAS  Google Scholar 

  107. Lane, H., Fernandez, A., Lamb, N. and Thomas, G. (1993) Nature 363, 170–172.

    PubMed  CAS  Google Scholar 

  108. Jefferies, H., Reinhard, C., Kozma, S. and Thomas, G. (1994) Proc. Natl. Acad. Sci. USA 91, 4441–4445.

    PubMed  CAS  Google Scholar 

  109. Terada, N., Patel, H., Takase, K., Kohno, K., Nairn, A. and Gelfand, E. (1994) Proc. Natl. Acad. Sci. USA 91, 11477–11481.

    PubMed  CAS  Google Scholar 

  110. Lin, T.-A., Kong, X., Haystead, T., Pause, A., Belsham, G., N., S. and Lawrence, J. (1994) Science 266, 653–656.

    PubMed  CAS  Google Scholar 

  111. Pause, A., Belsham, G., Gingras, A.-C., Donze, O., Lin, T.-A., Larence, J. and Sonenberg, N. (1994) Nature 371, 762–767.

    PubMed  CAS  Google Scholar 

  112. de Groot, R., Ballou, L. and Sassone-Corsi, P. (1994) Cell 79, 81–91.

    PubMed  Google Scholar 

  113. de Groot, R. and Sassone-Corsi, P. (1993) Mol. Endo. 7, 145–153.

    Google Scholar 

  114. Calvo, V., Wood, M., Gjertson, C., Vik, T. and Bierer, B. (1994) Eur. J. Immunol 24, 2664–2671.

    PubMed  CAS  Google Scholar 

  115. Morice, W., Brunn, G., Wiederrecht, G., Siekierka, J. and Abraham, R. (1993) J. Biol. Chem. 268, 3734–3738.

    PubMed  CAS  Google Scholar 

  116. Hunter, T. (1993) Cell 75, 839–841.

    PubMed  CAS  Google Scholar 

  117. Nourse, J., Firpo, E., Flanagan, W., Coats, S., Polyak, D., Lee, M.-H., Massague, J., Crabtree, G. and Roberts, J. (1994) Nature 372, 570–573.

    PubMed  CAS  Google Scholar 

  118. Polyak, K., Lee, M.-H., Erdjument-Bromage, H., Koff, A., Roberts, J., Tempst, P. and Massague, J. (1994) Cell 78, 59–66.

    PubMed  CAS  Google Scholar 

  119. Slingerland, J., Hengst, L., Pan, C.-H., Alexander, D., Stampfer, M. and Reed, S. (1994) Mol. Cell. Biol. 14, 3683–3694.

    PubMed  CAS  Google Scholar 

  120. Polyak, K., Kato, J.-Y., Solomon, M., Sherr, C., Massague, J., Roberts, J. and Koff, A. (1994) Genes and Develop. 8, 9–22.

    CAS  Google Scholar 

  121. Firpo, E., Koff, A., Solomon, M. and Roberts, J. (1994) Mol. Cell. Biol. 14, 4889–4901.

    PubMed  CAS  Google Scholar 

  122. Dumont, F., Altmeyer, A., Kastner, C., Fischer, P., Lemon, K., Chung, J., Blenis, J. and Staruch, M. (1994) J. Immunology 152, 992–1003.

    CAS  Google Scholar 

  123. Dumont, F. and Kastner, C. (1994) J. Cell Physiol. 160, 141–153.

    PubMed  CAS  Google Scholar 

  124. Sabers, C., Martin, M., Brunn, G., Williams, J., Dumont, F., Wiederrecht, G. and Abraham, R. (1994) J. Biol. Chem. 270, 815–822.

    Google Scholar 

  125. Brown, E., Albers, M., Shin, T., Ichikawa, K., Keith, C., Lane, W. and Schreiber, S. (1994) Nature 369, 756–758.

    PubMed  CAS  Google Scholar 

  126. Sabatini, D., Erdjument-Bromage, H., Lui, M., Tempst, P. and Snyder, S. (1994) Cell 78, 35–43.

    PubMed  CAS  Google Scholar 

  127. Chen, Y., Chen, H., Rhoad, A., Warner, L., Caggiano, T., Failli, A., Zhang, H., Hsiao, C.-L., Nakanishi, K. and Molnar-Kimber, K. (1994) Biochem. Biophys. Res. Comm. 203, 1–7.

    PubMed  CAS  Google Scholar 

  128. Fruman, D., Wood, M., Gjertson, C., Katz, H., Burakoff, S. and Bierer, B. (1995) Eur. J. Immunol 25, 563–571.

    PubMed  CAS  Google Scholar 

  129. Dhand, R., Hiles, I., Panayotou, G., Roche, S., Fry, M., Gout, I., Totty, N., Truong, O., Vicendo, P., Yonezawa, K., Kasuga, M., Courtneidge, S. and Waterfield, M. (1994) EMBO J. 13, 522–533.

    PubMed  CAS  Google Scholar 

  130. Chung, J., Grammer, T., Lemon, D., Kazlauskas, A. and Blenis, J. (1994) Nature 370, 71–75.

    PubMed  CAS  Google Scholar 

  131. Monfar, M., Lemon, K., Grammer, T., Cheatham, L., Chung, J., Vlahos, C. and Blenis, J. (1995) Mol. Cell. Biol. 15, 326–337.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Immunology, Mayo Clinic, Rochester, Minnesota, 55905, USA

    Robert T. Abraham

  2. Departments of Pharmacology, Mayo Clinic, Rochester, Minnesota, 55905, USA

    Candace J. Sabers, Gregory J. Brunn & Robert T. Abraham

  3. Department of Immunology Research, Merck Research Laboratories, Rathway, New Jersey, 07065, USA

    Gregory J. Wiederrecht, Mary M. Martin & Francis J. Dumont

Authors
  1. Gregory J. Wiederrecht
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Candace J. Sabers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gregory J. Brunn
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mary M. Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Francis J. Dumont
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Robert T. Abraham
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. CFSR Biomedical Science Institute, Austin, Texas, USA

    H. Y. Lim Tung

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Wiederrecht, G.J., Sabers, C.J., Brunn, G.J., Martin, M.M., Dumont, F.J., Abraham, R.T. (1995). Mechanism of action of rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells. In: Meijer, L., Guidet, S., Tung, H.Y.L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1809-9_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1809-9_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5731-5

  • Online ISBN: 978-1-4615-1809-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation