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Phosphorylation of elongation factor-1 (EF-1) by cdc2 kinase

  • Chapter
Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

Elongation factor-1 (EF-1) is a major substrate for cdc2 kinase in Xenopus oocytes. The guanine-nucleotide exchange factor EF-1βγδ, appears to have a highly complex macromolecular structure containing several GTP/GDP exchange proteins, valyl-tRNA synthetase, and a putative anchoring protein EF-1γ. During meiotic cell division, the factor becomes phosphorylated by cdc2 kinase, not only on EF-1γ, but also on two different phospho-acceptors on EF-1δ. Phosphorylation is concomitant with changes in protein synthesis in vivo. Xenopus oocytes, and potentially all cells, contain a multitude of heteromeric forms of the complex which postulates that EF-1βγδ is not a “house keeping” factor but a sophisticated regulatory element.

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References

  1. Norbury, C. and Nurse, P.(1992) Annu. Rev. Biochem. 61, 441–470.

    Article  PubMed  CAS  Google Scholar 

  2. Jessus, C. and Ozon, R.(1993) Comp. Biochem. Physiol. 106A, 431–448.

    Article  CAS  Google Scholar 

  3. Mulner-Lorillon, O., Poulhe, R., Cormier, P., Labbe, J.-C., Doree, M. and Belle, R.(1989) Febs Lett. 251, 219–224.

    Article  PubMed  CAS  Google Scholar 

  4. Belle, R., Cormier, P., Poulhe, R., Morales, J., Huchon, D. and Mulner-Lorillon, O.(1990) Int. J. Dev. Biol. 34, 111–115.

    PubMed  CAS  Google Scholar 

  5. Belle, R., Derancourt, J., Poulhe, R., Capony, J.P., Ozon, R. and Mulner-Lorillon, O.(1989) Febs Lett. 255, 101–104.

    Article  PubMed  CAS  Google Scholar 

  6. Janssen, G.M.C., Morales, J., Schipper, A., Mulner-Lorillon, O., Belle, R. and Moller, W.(1991) J. Biol. Chem. 266, 14885–14888.

    PubMed  CAS  Google Scholar 

  7. Wasserman, W.J., Richter, J.D. and Smith, L.D.(1982) Develop. Biol. 89, 152–158.

    Article  PubMed  CAS  Google Scholar 

  8. Hershey, J.W.B.(1991) Annu. Rev. Biochem. 60, 717–755.

    Article  PubMed  CAS  Google Scholar 

  9. Bourne, H.R., Sanders, D.A. and Mc Cormick, F.(1990) Nature 348, 125–132.

    Article  PubMed  CAS  Google Scholar 

  10. Riis, B., Rattan, S.I.S., Clark, B.F.C. and Merrick, W.C.(1990) Trends Biochem. Sci. 15, 420–424.

    Article  PubMed  Google Scholar 

  11. Bec, G., Kerjean, P., Zha, X.D. and Waller, J.P.(1989) J. Biol. Chem. 264, 21131–21137.

    PubMed  CAS  Google Scholar 

  12. Cormier, P., Osborne, H.B., Morales, J., Bassez, T., Pouhle, R., Mazabraud, A., Mulner-Lorillon, O. and Belle, R.(1991) Nucl. Acid. Res. 19, 6644.

    Article  CAS  Google Scholar 

  13. Maessen, G.D.F., Amons, R., Zeelen, J.P. and Moller, W. (1987) FEBS Lett. 223, 181–186.

    Article  PubMed  CAS  Google Scholar 

  14. Sanders, J., Maassen, J.A. and Moller, W.(1992) Nucl. Acids Res. 20, 5907–5910.

    Article  PubMed  CAS  Google Scholar 

  15. Kumabe, T., Sohma, Y. and Yamamoto, T.(1992) Nucl. Acids Res. 20, 2598.

    Article  PubMed  CAS  Google Scholar 

  16. Sheu, G.T. and Traugh, J.A.(1992) Nucl. Acids Res. 20, 5849.

    Article  PubMed  CAS  Google Scholar 

  17. Morales, J., Bassez, T., Cormier, P., Mulner-Lorillon, O., Belle, R. and Osborne, H.B. (1993) Develop. Genet. 14, 440–448.

    Article  CAS  Google Scholar 

  18. Mulner-Lorillon, O., Cormier, P., Cavadore, J.-C., Morales, J., Poulhe, R. and Belle, R.(1992) Exp. Cell Res. 202, 549–551.

    Article  PubMed  CAS  Google Scholar 

  19. Janssen, G.M.C. and Moller, W.(1988) Eur. J. Biochem. 171, 119–129.

    Article  PubMed  CAS  Google Scholar 

  20. Van Damme, H., Amons, R., Janssen, G. and Moller, W. (1991) Eur. J. Biochem. 197, 505–511.

    Article  PubMed  Google Scholar 

  21. Cormier, P., Osborne, H.B., Morales, J., Bassez, T., Minella, O., Poulhe, R., Belle, R. and Mulner-Lorillon, O.(1993) Nucl. Acids Res. 21, 743.

    Article  PubMed  CAS  Google Scholar 

  22. Van Damme, W.T.F., Amons, R., Karssies, R., Timmers, C.J., Janssen, G.M.C. and Moller, W.(1990) Biochim. Biophys. Acta 1050, 241–247.

    Article  PubMed  Google Scholar 

  23. Venema, R.C., peters, H.I. and Traugh, J.A.(1991) J. Biol. Chem. 266, 12574–12580.

    PubMed  CAS  Google Scholar 

  24. Moreno, S. and Nurse, P.(1990) Cell 61, 549–551.

    Article  PubMed  CAS  Google Scholar 

  25. Morales, J., Cormier, P., Mulner-Lorillon, O., Poulhe, R. and Belle, R.(1992) Nucl. Acids Res. 20, 4091.

    Article  PubMed  CAS  Google Scholar 

  26. Amons, R., Guerrucci, M.A., Karssies, R.H., Morales, J., Cormier, P., Moller, W. and Belle, R.(1994) Biochim. Biophys. Acta 1218, 346–350.

    Article  PubMed  CAS  Google Scholar 

  27. Abel, T. and Maniatis, T.(1989) Nature 341, 24–25.

    Article  PubMed  CAS  Google Scholar 

  28. Sanders, J., Raggiaschi, R., Morales, J. and Moller, W.(1993) Biochim. Biophys. Acta 1174, 87–90.

    Article  PubMed  CAS  Google Scholar 

  29. Matsumoto, S., Oizumi, N., Taira, H. and Ejiri, S.(1992) Febs Lett. 311, 46–48.

    Article  PubMed  CAS  Google Scholar 

  30. Mulner-Lorillon, O., Minella, O., Cormier, P., Capony, J.P., Cavadore, J.C., Morales, J., Poulhe, R. and Belle, R.(1994) J. Biol. Chem. 269, 20201–20207.

    PubMed  CAS  Google Scholar 

  31. Cormier, P., Mulner-Lorillon, O., Ozon, R. and Belle, R.(1989) Biosci. Rep. 9, 351–358.

    Article  PubMed  CAS  Google Scholar 

  32. Minella, O., Cormier, P., Morales, J., Poulhe, R., Belle, R. and Mulner-Lorillon, O.(1994) Cell. Mol. Biol. 40, 521–525.

    PubMed  CAS  Google Scholar 

  33. Morales, J., Mulner-Lorillon, O., Denis, H. and Belle, R.(1991) Biochimie 73, 1249–1253.

    Article  PubMed  CAS  Google Scholar 

  34. Lew, Y., Jones, D.V., Mars, W.M., Evans, D., Byrd, D. and Frazier, M.L.(1992) Pancreas 7, 144–152.

    Article  PubMed  CAS  Google Scholar 

  35. Viel, A., Le Maire, M., Philippe, H., Morales, J., Mazabraud, A. and Denis, H.(1991) J. Biol. Chem. 266, 10392–10399.

    PubMed  CAS  Google Scholar 

  36. Deschamps, S., Morales, J., Mazabraud, A., Le Maire, M., Denis, H. and Brown, D.D.(1991) J. Cell Biol. 114, 1109–1111.

    Article  PubMed  CAS  Google Scholar 

  37. Krieg, P.A., Varnum, S.M., Wormington, W.M. and Melton, D.A.(1989) Develop. Biol. 133, 93–100.

    Article  PubMed  CAS  Google Scholar 

  38. Charbonneau, M., Bonnec, G. and Boujard, D.(1990) Cell Differ. Develop. 31, 197–206.

    Article  CAS  Google Scholar 

  39. Sagata, N., Daar, I., Oskarsson, M., Showalter, S.D. and Van de Woude, G.F.(1989) Science 245, 643–646.

    Article  PubMed  CAS  Google Scholar 

  40. Paris, J., Le Guellec, R., Couturier, A., Le Guellec, K., Omilli, F., Camonis, J., MacNeill, S. and Philippe, M.(1991) Proc. Natl. Acad. Sci. USA 88, 1039–1043.

    Article  PubMed  CAS  Google Scholar 

  41. Sagata, N., Watanabe, N., Vande Woude, G.F. and Ikawa, Y.(1989) Nature 342, 512–518.

    Article  PubMed  CAS  Google Scholar 

  42. Gabrielli, B.G., Roy, L.M. and Mailer, J.L.(1993) Science 259, 1766–1769.

    Article  PubMed  CAS  Google Scholar 

  43. Dworkin, M.B. and Dworkin-Rastl, E.(1985) Develop. Biol. 112, 451–457.

    Article  PubMed  CAS  Google Scholar 

  44. Morales, J., Minella, O., Mulner-Lorillon, O., Cormier, P., Poulhe, R. and Belle, R. (1994) Reg. Biochim. 1, 43–49.

    Google Scholar 

  45. Woodland, H.R.(1974) Develop. Biol. 40, 90–101.

    Article  PubMed  CAS  Google Scholar 

  46. Richter, J.D., Wasserman, W.J. and Smith, L.D.(1982) Develop. Biol. 89, 159–167.

    Article  PubMed  CAS  Google Scholar 

  47. Audet, R.G., Goodchild, J. and Richter, J.D.(1987) Develop. Biol. 121, 58–68.

    Article  PubMed  CAS  Google Scholar 

  48. Ryazanov, A.G., Rudkin, B.B. and Spirin, A.S.(1991) Febs Lett. 285, 170–175.

    Article  PubMed  CAS  Google Scholar 

  49. Nielsen, P.J., Thomas, G. and Mailer, J.L.(1982) Proc. Natl. Acad. Sci. USA 79, 2937–2941.

    Article  PubMed  CAS  Google Scholar 

  50. Gonen, H., Smith, C.E., Siegel, N.R., Kahana, C., Merrick, W.C., Chakraburtty, K., Schwartz, A.L. and Ciechanover, A.(1994) Proc. Natl. Acad. Sci. USA 91, 7648–7652.

    Article  PubMed  CAS  Google Scholar 

  51. Shiina, N., Gotoh, Y., Kubomura, N., Iwamatsu, A. and Nishida, E. (1994) Science 266, 282–285.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Biologie Cellulaire de l’Ovocyte, CNRS URA 1449, INRA, Université Pierre et Marie Curie, 9 quai St Bernard, 75005, Paris, France

    Robert Bellé, Odile Minella, Patrick Cormier, Julia Morales, Robert Poulhe & Odile Mulner-Lorillon

Authors
  1. Robert Bellé
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  2. Odile Minella
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  3. Patrick Cormier
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  4. Julia Morales
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  5. Robert Poulhe
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  6. Odile Mulner-Lorillon
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. CFSR Biomedical Science Institute, Austin, Texas, USA

    H. Y. Lim Tung

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© 1995 Springer Science+Business Media New York

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Bellé, R., Minella, O., Cormier, P., Morales, J., Poulhe, R., Mulner-Lorillon, O. (1995). Phosphorylation of elongation factor-1 (EF-1) by cdc2 kinase. In: Meijer, L., Guidet, S., Tung, H.Y.L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1809-9_21

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  • DOI: https://doi.org/10.1007/978-1-4615-1809-9_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5731-5

  • Online ISBN: 978-1-4615-1809-9

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