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Implications for cAMP-dependent protein kinase in the maintenance of the interphase state

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

The cAMP dependent protein kinase (A-kinase) is one of the first and best studied kinases in mammalian cells. There is extensive evidence that A-kinase activity acts antagonistically toward mitotic entry both in oocyte and somatic cells. Firstly, A-kinase seems to directly compromise the activation process of the cdc2 cyclin B mitotic kinase. Secondly, as shown by specific in vivo inhibition of A-kinase using microinjection of a stable form of its inhibitor peptide PKI, A-kinase modulates several key interphase cellular processes including cytoskeletal dynamics, transcription, chromatin structure and nuclear localization. We discuss the potential mechanisms involved in the down regulation of A-kinase activity at the interphase/mitosis transition.

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Authors and Affiliations

  1. Centre de Recherches de Biochimie Macromoléculaire, CNRS-INSERM, 34820, Montpellier, France

    Anne Fernandez, Jean-Claude Cavadore, Jacques Demaille & Ned Lamb

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  1. Anne Fernandez
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  2. Jean-Claude Cavadore
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  3. Jacques Demaille
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  4. Ned Lamb
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. CFSR Biomedical Science Institute, Austin, Texas, USA

    H. Y. Lim Tung

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Fernandez, A., Cavadore, JC., Demaille, J., Lamb, N. (1995). Implications for cAMP-dependent protein kinase in the maintenance of the interphase state. In: Meijer, L., Guidet, S., Tung, H.Y.L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1809-9_19

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  • DOI: https://doi.org/10.1007/978-1-4615-1809-9_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5731-5

  • Online ISBN: 978-1-4615-1809-9

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