Abstract
Recent studies1-5 have revealed several time-adaptive components in the classic Hering-Breuer inflation reflex (HBIR)6,7 modulation of the respiratory rhythm elicited by lung inflation or electrical vagal stimulation. The primary adaptive component features a slow exponential decay that evidences a gradual habituation of HBIR, possibly due to time-dependent adaptations in the primary central pathway for neurotransmission of vagal-volume feedback (VVF) to the respiratory central pattern generator (RCPG). A secondary adaptive component is characterized by an abrupt post-stimulus rebound and exponential recovery of the respiratory rhythm following the cessation of the vagal input, an effect that has been linked to NMDA receptor-dependent desensitization of neurotransmission in a secondary vagally-modulated pathway via the pontine pneumotaxic region.3,4 The combined habituation-desensitization of HBIR via the primary and secondary central pathways conform with the classic dual-process model of nonassociative learning 4,8 These observations provide the first indication that nonassociative learning may play a role in the vagal control of the respiratory rhythm.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D. L. Young, M. S. Siniaia, and C. -S. Poon, Adaptive modulation of respiratory rhythm by vagal input: effect of gating, Soc. Neurosci. Abstr. 378, (1998).
C.-S. Poon and M. S. Siniaia, Plasticity of cardiorespiratory neural processing: classification and computational function, Respir. Physiol. 122, 83–109 (2000).
C. -S. Poon, D. L. Young, and M. S. Siniaia, High-pass filtering of carotid-vagal influences on expiration in rat: role of N-methyl-D-aspartate receptors, Neurosci. Lett. 284(1–2), 5–8 (2000).
M. S. Siniaia, D. L. Young, and C. -S. Poon, Habituation and desensitization of the Hering-Breuer reflex in rat, J. Physiol. (London) 523, 479–91(2000).
D. L. Young, M. S. Siniaia, and C. -S. Poon, A gated neural differentiator-integrator linked to nonassociative learning in the mammalian respiratory central pattern generator, (submitted).
J. Breuer, Self-steering of respiration through the nerves vagus (circa 1868), in: Breathing: Hering-Breuer Centenary Symposium, edited by R. Porter (Churchill, London, 1970), pp. 365–397.
E. Hering, Self-steering of respiration through the nerves vagus (circa 1868), in: Breathing: Hering-Breuer Centenary Symposium,edited by R. Porter (Churchill, London, 1970), pp. 359–364.
P. M. Groves and R.F. Thompson, Habituation: a dual-process theory, Phys. Rev. 77, 419–450 (1970).
J. M. Bower and D. Beeman, The book of Genesis: exploring realistic neural models with the General Neural Simulation System, (Springer-Verlag New York, New York, 1995).
I. A. Rybak, J. F. Paton, and J. S. Schwaber, Modeling neural mechanisms for genesis of respiratory rhythm and pattern. I. Models of respiratory neurons, J. Neurophysiol. 77, 1994–2006 (1997)
I. A. Rybak, J. F. Paton, and J. S. Schwaber, Modeling neural mechanisms for genesis of respiratory rhythm and pattern. II. Network models of the central respiratory pattern generator, J. Neurophysiol. 77, 2007–26 (1997).
I. A. Rybak, J. F. Paton, and J. S. Schwaber, Modeling neural mechanisms for genesis of respiratory rhythm and pattern. III. Comparison of model performances during afferent nerve stimulation, J. Neurophysiol. 77,2027–39 (1997).
K. Takano and F. Kato, Inspiration-promoting vagal reflex under NMDA receptor blockade in anaesthetized rabbits, J. Physiol. (London) 516, 571–82 (1999).
D. L. Young, M. S. Siniaia, and C. -S. Poon, NMDA receptor blockade unmasks novel gating and memory mechanisms in vagal control of respiratory rhythm, (this volume).
W. Rall, Distinguishing theoretical synaptic potentials computed for different soma-dendritic distribution of synaptic inputs, J. Neurophysiol., 30, 1138–1168 (1967).
J. J. B. Jack, D. Noble, and R. W. Tsien, Electric Current Flow in Excitable Cells (Calderon Press, Oxford, 1975).
W. Wang, M. L. Fung, and W. M. St John, Pontile regulation of ventilatory activity in the adult rat, J. Appl. Physiol. 74, 2801–11 (1993).
A. S. Foutz AS, J. Champagnat, and M. Denavit-Saubie, Involvement of N-methyl-D-aspartate (NMDA) receptors in respiratory rhythmogenesis, Brain Res. 500, 199–208 (1989).
R. Monteau, P. Gauthier, P. Rega, and G. Hilaire, Effects of N-methyl-D-aspartate (NMDA) antagonist MK-801 on breathing pattern in rats, Neurosci. Lett. 109, 134–9 (1990).
C. A. Connelly, M. R. Otto-Smith MR, and J. L. Feldman, Blockade of NMDA receptor-channels by MK-801 alters breathing in adult rats, Brain Res. 596, 99–110 (1992).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Young, D.L., Siniaia, M.S., Poon, CS. (2001). Model of Nonassociative Learning in Vagal-Pontine Modulation of the Respiratory Rhythm. In: Poon, CS., Kazemi, H. (eds) Frontiers in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 499. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1375-9_40
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1375-9_40
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5522-9
Online ISBN: 978-1-4615-1375-9
eBook Packages: Springer Book Archive