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Human Milk and the Response of Intestinal Epithelium to Infection

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Bioactive Components of Human Milk

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 501))

Abstract

The discussion about breast-feeding vs. formula is not an invention of modern times. Its roots go back to ancient times, and we find recommendations to delay breast-feeding from Indian authors as early as 1500 BC. During these centuries, philosophical theories and mythology, rather than facts about nutrition or immunology, dominated this dispute. Important revisions of pathologic concepts at the end of the 19thcentury allowed a scientific evaluation of the benefits of breast-feeding. The finding that infectious diseases were caused by microorganisms provided the basis for the idea that human milk might help the neonate to overcome these illnesses. Paul Ehrlich, coworker of Robert Koch and one of the most important microbiologists and immunologists in medical history, was the first to show the transfer of maternal antibodies to the neonate by human milk (Ehrlich & Hubner 1892; Brieger & Ehrlich 1893). Since then a variety of other immunologically active components have been described in human milk and evidence is accumulating that human milk may also exert active immunostimulatory and immunomodulatory functions and help the development of the child’s own mucosal immune system

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  1. Developmental Gastroenterology Laboratory and Mucosal Immunology Laboratory Combined Program in Pediatric Gastroenterology and Nutrition Massachusetts General Hospital, The Children’s Hospital, Boston, MA, 02129, USA

    Kathrin Bernt & W. Allan Walker

  2. East Humboldt University of Berlin, Virchow Clinic, 10099, Berlin, Germany

    Kathrin Bernt

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  1. Kathrin Bernt
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  1. Waltham, Massachusetts and Harvard Medical School, Shriver Center, Boston, Massachusetts

    David S. Newburg

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Bernt, K., Walker, W.A. (2001). Human Milk and the Response of Intestinal Epithelium to Infection. In: Newburg, D.S. (eds) Bioactive Components of Human Milk. Advances in Experimental Medicine and Biology, vol 501. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1371-1_2

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  • DOI: https://doi.org/10.1007/978-1-4615-1371-1_2

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