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The Molecular Biology of Hepatitis A Virus

  • Chapter
Hepatitis Viruses

Abstract

Hepatitis A virus (HAV) is a positive-strand RNA virus classified within the family Picornaviridae. The mature HAV virion is a small 27 nm, generally spherical, non-enveloped particle (1), with three major capsid proteins encapsidating a single-stranded, positive-sense RNA genome about 7.5 kb in length. Although there are many attributes of the virus that distinguish it from other picornaviruses, HAV shares a number of features in common with other members of the family Picornaviridae, particularly those in the genus Aphthovirus (foot and mouth disease virus, FMDV) and genus Cardiovirus (e.g., encephalomyocarditis virus, EMCV). Its genomic organization is also similar to that of all other picornaviruses, including members of the Enterovirus (e.g., poliovirus) and Rhinovirus genera. In recognition of its distinctive features, however, HAV is classified as the type species of a separate genus, the genus Hepatovirus. An important human pathogen, HAV is a common cause of acute viral hepatitis and one of five human viruses typically associated with this disease.

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Authors and Affiliations

  1. Institut Pasteur, Paris, France

    Annette Martin

  2. University of Texas Medical Branch, Galveston, TX, 77555, USA

    Stanley M. Lemon

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  1. Annette Martin
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  2. Stanley M. Lemon
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  1. University of Southern California, USA

    J.-H. James Ou

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© 2002 Springer Science+Business Media New York

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Martin, A., Lemon, S.M. (2002). The Molecular Biology of Hepatitis A Virus. In: Ou, JH.J. (eds) Hepatitis Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0881-6_2

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  • DOI: https://doi.org/10.1007/978-1-4615-0881-6_2

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