Abstract
Tissue-selective trafficking of memory and effector T and B lymphocytes is mediated by unique combinations of adhesion molecules and chemokines. The discovery of several related epithelial-expressed chemokines (TECK/CCL25 in small intestine, CTACK/CCL27 in skin, and MEC/CCL28 in diverse mucosal sites) now highlights an important role for epithelial cells in controlling homeostatic lymphocyte trafficking, including the localization of cutaneous and intestinal memory T cells, and of IgA plasma cells. Constitutively expressed epithelial chemokines may help determine the character of local immune responses and contribute to the systemic organization of the immune system.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bowman, E.P., Kuklin, N., Youngman, K.R., Lazarus, N., Kunkel, E.J., Pan, J., Greenberg, H.B., and Butcher, E.C., 2002, The intestinal chemokine TECK (CCL25) attracts IgA antibody secreting cells, J.Exp.Med., 195:269.
Butcher, E.C., 1991, Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity, Cell, 67:1033.
Butcher, E.C., Williams, M., Youngman, K., Rott, L., and Briskin, M., 1999, Lymphocyte trafficking and regional immunity, Adv.Immunol., 72:209.
Cahill, R.N., Poskitt, D.C., Frost, D.C., and Trnka, Z., 1977, Two distinct pools of recirculating T lymphocytes: migratory characteristics of nodal and intestinal T lymphocytes, J.Exp.Med., 145:420.
Campbell, D.J. and Butcher, E.C., 2002, Rapid acquisition of tissue-specific homing phenotypes by CD4+ T cells activated in cutaneous or mucosal lymphoid tissues, J.Exp.Med., 195:135.
Campbell, J.J., Brightling, C.E., Symon, F.A., Qin, S., Murphy, K.E., Hodge, M., Andrew, D.P., Wu, L., Butcher, E.C., and Wardlaw, A.J., 2001, Expression of chemokine receptors by lung T cells from normal and asthmatic subjects, J.Immunol., 166:2842.
Campbell, J.J., Haraldsen, G., Pan, J., Rottman, J., Qin, S., Ponath, P., Andrew, D.P., Warnke, R., Ruffing, N., Kassam, N, Wu, L., and Butcher, E.C., 1999, The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells, Nature, 400:776.
Czinn, S.J. and Lamm, M.E., 1986, Selective chemotaxis of subsets of B lymphocytes from gut-associated lymphoid tissue and its implications for the recruitment of mucosal plasma cells, J.Immunol., 136:3607.
Finke, D., Baribaud, F., Diggelmann, H., and Acha-Orbea, H., 2001, Extrafollicular plasmablast B cells play a key role in carrying retroviral infection to peripheral organs, J.Immunol., 166:6266.
Fiocchi, C., 1998, Inflammatory bowel disease: etiology and pathogenesis, Gastroenterology, I15:182.
Gowans, J.L. and Knight, E.J., 1964, The route of recirculation of lymphocytes in the rat., Proc.R.Soc.London Ser.B., 159:257
Hargreaves, D.C., Hyman, P.L., Lu, T.T., Ngo, V.N., Bidgol, A., Suzuki, G., Zou, Y.R., Littman, D.R., and Cyster, J.G., 2001, A coordinated change in chemokine responsiveness guides plasma cell movements, J.Exp.Med., 194:45.
Jarmin, D.I., Rits, M., Bota, D., Gerard, N.P., Graham, G.J., Clark-Lewis, I., and Gerard, C., 2000, Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine, J.Immunol., 164:3460.
Kroes, I., Lepp, P.W., and Reiman, D.A., 1999, Bacterial diversity within the human subgingival crevice, Proc.Natl.Acad.Sci.U.S.A., 96:145–147.
Kunkel, E.J., Campbell, J.J., Haraldsen, G., Pan, J., Boisvert, J., Roberts, A.I., Ebert, E.C., Vierra, M.A., Goodman, S.C., Genovese, M.C., Wardlaw, A.J., Greenberg, H.B., Parker, C.M., Butcher, E.C., Andrew, D.P., and Agace, W.W., 2000, Lymphocyte CCR9 and epithelial TECK expression distinguish the small intestinal immune compartment: epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity, J.Exp.Med., 192:761.
McDermott, M.R. and Bienenstock, J., 1979, Evidence for a common mucosal immunologic system. I.
Migration of B immunoblasts into intestinal, respiratory, and genital tissues, JImmunol.,122:1892.
Middleton, J., Neil, S., Wintle, J., Clark-Lewis, I., Moore, H., Lam, C., Auer, M., Hub, E., and Rot, A., 1997,Transcytosis and surface presentation of IL-8 by venular endothelial cells, Cell, 91:385.
Morales, J., Homey, B., Vicari, A.P., Hudak, S., Oldham, E., Hedrick, J., Orozco, R., Copeland, N.G., Jenkins, N.A., McEvoy, L..M., and Zlotnik, A., 1999, CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells, Proc.Natl.Acad.Sci. U.S.A., 96:14470.
Pan, J., Kunkel, E.J., Gosslar, U., Lazarus, N., Langdon, P., Broadwell, K., Viena, M.A., Genovese, M.C., Butcher, E.C., and Soler, D., 2000, A novel chemokine ligand for CCRIO and CCR3 expressed by epithelial cells in mucosal tissues, J.Immunol., 165:2943.
Papadakis, K.A., Prehn, J., Nelson, V., Cheng, L., Binder, S.W., Ponath, P.D., Andrew, D.P., and Targan, S.R., 2000, The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system, J.Immunol., 165:5069.
Pitman, R.S. and Blumberg, R.S., 2000, First line of defense: the role of the intestinal epithelium as an active component of the mucosal immune system, J.Gastroenterol., 35:805.
Reiss, Y., Proudfoot, A.E., Campbell, J.J., and Butcher, E.C., 2001, CCR4 and the CCR10 ligand CTACK in lymphocyte trafficking to inflamed skin, J.Exp.Med.,194:1541.
Robert, C. and Kupper, T.S., 1999, Inflammatory skin diseases, T cells, and immune surveillance, N.Engl.J.Med., 341:1817.
Shaw, S.K. and Brenner, M.B., 1995, The beta 7 integrins in mucosal homing and retention, Semin.Immunol., 7:335.
von Andrian, U.H. and Mackay, C.R., 2000, T-cell function and migration. Two sides of the same coin, N.Eng1.J.Med., 343:1020.
Wang, W., Soto, H., Oldham, E.R., Buchanan, M.E., Homey, B., Catron, D., Jenkins, N., Copeland, N.G., Gilbert, D.J., Nguyen, N., Abrams, J., Kershenovich, D., Smith, K., McClanahan, T., Vicari, A.P., and Zlotnick, A., 2000, Identification of a Novel CC Chemokine (CCL28) which binds CCRIO (GPR2), J. Biol. Chem., 275:22313.
Wurbel, M.-A., Philippe, J.-M., Nguyen, C., Victorero, G., Freeman, T., Wooding, P., Miazek, A., Mattel, M.-G., Malissen, M., Jordan, B.R., Malissen, B., Carrie, A., and Naquet, P.,2000, The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double-and single-positive thymocytes expressing the TECK receptor CCR9, Eur.J.Immunol., 30:262.
Zabel, B.A., Agace, W.W., Campbell, J.J., Heath, H.M., Parent, D., Roberts, A.I., Ebert, E.C., Kassam, N., Qin, S., Zovko, M., LaRosa, G.J., Yang, L.L., Soler, D., Butcher, E.C., Ponath, P.D., Parker, C.M., and Andrew, D.P., 1999, Human G protein-coupled receptor GPR-9–6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis, J.Exp.Med., 190:1241.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Kunkel, E.J., Butcher, E.C. (2002). Homeostatic Chemokines and the Targeting of Regional Immunity. In: Gupta, S., Butcher, E., Paul, W. (eds) Lymphocyte Activation and Immune Regulation IX. Advances in Experimental Medicine and Biology, vol 512. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0757-4_9
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0757-4_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5226-6
Online ISBN: 978-1-4615-0757-4
eBook Packages: Springer Book Archive